Epilepsy is a disorder characterized by recurring seizures, which are disturbances in the electrical activity in the brain.
Seizure types range from a momentary disruption of senses to a loss of consciousness and violent movements that can last for
minutes. Epilepsy affects people of all ages, from infants to the aged. There is no single cause for epilepsy; however epilepsy
can sometimes be associated with a positive family history, illness, head injury, or abnormal brain development. It is estimated
that 1-2% of the population has epilepsy, and of those individuals, approximately two-thirds respond well to medical treatment.
NIH/NINDS and its community-based research partners are dedicated to finding a cure and/or preventing epilepsy in individuals
who have or are at risk for seizures. This web page is designed to provide some information about ongoing epilepsy research
efforts.
Select this link for more information about epilepsy: NINDS Epilepsy Information Page
Table of Contents (click to jump to sections)
"Benchmarks" for Epilepsy Research
NINDS Anticonvulsant Screening Program
The Judith Hoyer Lecture on Epilepsy
Workshop Summaries
Publications
Announcements
Congressional Appropriations Committee Reports
Additional Links
"Benchmarks" for Epilepsy Research
Resources
Anticonvulsant Screening Program (ASP) is a long-standing government sponsored effort established to encourage and facilitate the discovery, optimization and development
of new therapeutic agents for the treatment of seizure related disorders. One of the ASP's major goals is to establish international
collaborative partnerships among governments, academia, and industry that act to stimulate the search and development of better
treatments and an eventual cure for the epilepsies. Recently, through a broader HHS funded effort, the ASP has expanded its screening capabilities. We are now accepting compounds intended
to act as counter-measures against potential chemical threats stemming from either intentional or accidental exposure to various
nerve agents. For this purpose, the ASP now employs a series of models that mimic the effects of CNS exposure to nerve agents
(actual nerve agents are not used in evaluations). To participate or for more information please contact a member of our program staff listed in our website (http://www.ninds.nih.gov/asp).
Select this link to view additional information about the NINDS ASP program
Workshop Summaries
- Workshop on Nonepileptic Seizures May 1-3, 2005
- Imaging Markers of Epileptogenesis: New Research Directions April 10-11, 2003
- Workshop on Channelopathies November 20-21, 2002
- Health Disparities in Epilepsy Planning Panel November 13, 2002
- DNA Microarrays and Epilepsy Research October 4, 2002
- Models II: Identification and Characterization of Animal Models of Human Therapy Resistance and Epileptogenesis September 26 - 27, 2002
- Molecular Analysis of Complex Genetic Epilepsies January 31 - February 1, 2002
- Workshop on Antiepileptic Drug (AED) Monotherapy Indications March 8-9, 2001
- Models for Epilepsy & Epileptogenesis NINDS Workshop March 1-2, 2001
- Curing Epilepsy: Focus on the Future March 30-31, 2000.
- Select this link to view summaries of other NINDS-sponsored workshops and conferences
Publications
Curing Epilepsy: The Promise of Research
LaFrance CW Jr , Alper K, Babcock D, et al. Nonepileptic seizures treatment workshop summary. Epilepsy & Behavior 2006; 8:451-461.
Jacobs MP, Fischbach GD, Davis MR, et al. Future directions for epilepsy research. Neurology 2001; 57:1536-1542.
Announcements
Select this link to view additional NINDS funding information by program area
Congressional Appropriations Committee Reports
- Epilepsy Research Coordination and Progress in Implementing the Epilepsy Research Benchmarks - 2005 (PDF - 80 KB)
In the Senate Report (No. 108-345) accompanying the Fiscal Year 2005 appropriations bill for the National Institutes of Health
(NIH), the Senate Committee on Appropriations requested that NIH report on efforts to coordinate research activities across
NIH and on progress made to implement the Epilepsy Research Benchmarks.
- Progress in Implementing Epilepsy Research Benchmarks and Coordinating Research Efforts - 2003 (PDF - 5,799 KB)
In the Senate Report (No. 107-216) accompanying the Fiscal Year 2003 appropriations bill for the National Institutes of Health
(NIH), the Senate Committee on Appropriations requested that NIH report on the progress made to implement the Epilepsy Research
Benchmarks, and on efforts to coordinate research activities across NIH.
- Epilepsy Research Benchmarks Implementation Plan - 2002 (PDF - 50 KB)
In the Senate Report (No. 107-84) accompanying the Fiscal Year 2002 appropriations bill for the National Institutes of Health
(NIH), the Committee encouraged NIH to develop a plan to implement the benchmarks for epilepsy research that resulted from
the March 2000 NINDS conference "Curing Epilepsy: Focus on the Future" and to coordinate research activities across NIH Institutes.
The benchmarks were developed for the epilepsy research community to use as milestones in measuring progress towards finding
a cure for epilepsy.
Additional Links: