T cells That See Antigens Independently of MHC (NIH-Only) |
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| Launch in standalone player | |
| Air date: | Tuesday, March 10, 2009, 8:00:00 AM |
| Category: | NCI CCR Grand Rounds (NIH Only) |
| Description: | Dr. Singer is Chief of the Experimental Immunology Branch, CCR, NCI. He received his B.S. from MIT and his M.D. from Columbia University and has been working in the field of T cell development for over 30 years. He is a highly original and creative scientist who has made many important contributions to our understanding of T cell immunology and T cell development in the thymus, including such original discoveries as the role of self antigens in thymic selection; thymic crosstalk (the regulation of thymic epithelial cell differentiation by thymocytes); coreceptor tuning (the adjustment of CD8 coreceptor expression levels on T cells to the self-specificity of their TCR), coreceptor reversal (the genetic basis for selection and generation of cytotoxic lineage T cells in the thymus); and the requirement for costimulation for clonal deletion in the thymus. His most recent work has solved two important problems in T cell immunology: how and why the thymus selects an exclusively MHC-restricted T cell receptor repertoire and how CD4/CD8 lineage choice is determined during thymocyte development.
Dr. Singer has published over 215 papers and reviews and has served on editorial boards of many journals, including serving as Reviews Editor for Immunity and Advisory Editor for The Journal of Experimental Medicine. He has served on numerous Scientific Advisory Boards including advising the Mayo Clinic in Rochester, MN; the National Health Research Institute in Taiwan; the MRC Center for Immune Regulation in Birmingham, England; the Barbara Davis Center for Childhood Diabetes in Denver, CO; and he currently serves as Chairman of the Visiting Professor Advisory Committee for Chiba University in Chiba, Japan. Dr. Singer has trained over 40 postdoctoral fellows, many of whom are distinguished scientists and scientific leaders, and was awarded the NCI Outstanding Mentor Award in 2006. NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link: http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx |
| Author: | Alfred Singer, M.D. |
| Runtime: | 60 minutes |
| CIT File ID: | 14955 |
| CIT Live ID: | 7521 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14955 |