The Harold Varmus Papers
- Title:
- Annealing cDNA3' and cDNA5' to Linear ASV DNA
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- Description:
- In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process.
- Number of Image Pages:
- 1 (171,490 Bytes)
- Date Supplied:
- 1978
- Creator:
- [University of California, San Francisco]
- Source:
- Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
- Rights:
- Reproduced with permission of the Regents of the University of California.
- Subject:
-
- Medical Subject Headings (MeSH):
- Sarcoma Viruses, Avian
- DNA
- Exhibit Category:
- Retroviruses and the Genetic Origins of Cancer, 1970-1993
- Box Number: 7
-
- Folder Number: 5
-
- Unique Identifier:
- MVBBJQ
- Document Type:
- Slides (photographs)
- Charts (graphic documents)
- Language:
- English
- Format:
- image/jpeg
- image/tif
- Physical Condition:
- Good
- Series: Collection Number MSS 84-25
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- SubSeries: Research, 1970-1984
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- Folder: Slides from Binder - Avian DNA, viral DNA, sarc, 1978-1979
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- Metadata Last Modified Date:
- 2006-10-11
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health,
Department of Health & Human Services
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High resolution version (2,589,159 Bytes)