The Harold Varmus Papers

Title:: [Revertant DNA data] (image 2)

(high resolution jpg) High resolution version (8,135,867 Bytes)

Description:

Varmus made extensive use of gel electrophoresis in his study of the genetics of retroviruses, namely to determine the quantity and structure of viral DNA prepared from extracts from the nucleus and cytoplasm (the substance surrounding the nucleus) of cells infected with Avian Sarcoma Virus (ASV). The technology enabled Varmus, for example, to show the existence of proviruses of ASV, the double-stranded DNA version of the double-stranded RNA of which the ASV genome is made. By forming a provirus, retroviruses are able to integrate themselves into the DNA of host cells.

The lanes shown in this figure were formed when electrically charged (ionic) DNA fragments, which had been dissolved in a solvent and spread on an agarose gel as a support medium, migrate across an electric field and are separated according to the speed of their migration as well as according to changes they undergo during their migration.

Number of Image Pages:

1 (151,199 Bytes)

Date Supplied:

1978-1979

Creator:

[Varmus, Harold]

Source:

Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers

Rights:

Reproduced with permission of the Regents of the University of California.

Subject:

Medical Subject Headings (MeSH):: DNA

Exhibit Category:

Retroviruses and the Genetic Origins of Cancer, 1970-1993

Relation:

[Revertant DNA data] (image 1) [1978-1979]

[Revertant DNA data] (image 3) [1978-1979]

Box Number: 6

Folder Number: 16

Unique Identifier:

MVBBHQ

Document Type:

Photographic prints

Format:

image/jpeg

image/tif

Physical Condition:

Good

Series: Collection Number MSS 84-25

SubSeries: Research, 1970-1984

Folder: Illustrations, 1978-1979

Metadata Last Modified Date:

2006-10-18

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