The National Institute of Diabetes & Digestive & Kidney Diseases

The role of peripheral conversion of thyroid hormone in the modulation of thyroid hormone action: Dr. Celi’s research interest is aimed to the study of the role of the peripheral metabolism of tthyroid hormones, regulated by the deiodinases, in the modulation of the tissue-specificity of thyroid hormone action. Dr. Celi uses both in vitro and cell culture systems as well as human studies. The latter are mainly focused on the study of the interaction between peripheral metabolism of thyroid hormone and glucose, energy, and lipid homeostasis.

1. Fu M Kazlauskaite R Baracho Mde F Santos MG Brandao-Neto J Villares S Celi FS Wajchenberg BL Shuldiner AR Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects. J Clin Endocrinol Metab (89): 2916-22, 2004. [Full Text/Abstract]

2. Mentuccia D Proietti-Pannunzi L Tanner K Bacci V Pollin TI Poehlman ET Shuldiner AR Celi FS Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes (51): 880-3, 2002. [Full Text/Abstract]

3. Celi FS Shuldiner AR The role of peroxisome proliferator-activated receptor gamma in diabetes and obesity. Curr Diab Rep (2): 179-85, 2002. [Full Text/Abstract]

4. Gargano L Mentuccia D Conti L Viceconti N Sibilla R Danese D Celi FS Gandolfo G Centanni M Age-related prevalence of platelet-associated immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome. Horm Res (56): 172-6, 2001. [Full Text/Abstract]

5. d''Amati G di Gioia CR Mentuccia D Pistilli D Proietti-Pannunzi L Miraldi F Gallo P Celi FS Increased expression of thyroid hormone receptor isoforms in end-stage human congestive heart failure. J Clin Endocrinol Metab (86): 2080-4, 2001. [Full Text/Abstract]

6. Canettieri G Celi FS Baccheschi G Salvatori L Andreoli M Centanni M Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element. Endocrinology (141): 1804-13, 2000. [Full Text/Abstract]

7. Celi FS Negri C Tanner K Raben N De Pablo F Rovira A Pallardo LF Martin-Vaquero P Stern MP Mitchell BD Shuldiner AR Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Mexican Americans with Type 2 diabetes mellitus. Diabetes Metab Res Rev (16): 370-7, 2000. [Full Text/Abstract]

8. Celi FS Mentuccia D Proietti-Pannunzi L di Gioia CR Andreoli M Preparing polyA-containing RNA internal standards for multiplex competitive RT-PCR. Biotechniques (29): 454, 457-8, 2000. [Full Text/Abstract]

9. Celi FS Canettieri G Mentuccia D Proietti-Pannunzi L Fumarola A Sibilla R Predazzi V Ferraro M Andreoli M Centanni M Structural organization and chromosomal localization of the human type II deiodinase gene. Eur J Endocrinol (143): 267-71, 2000. [Full Text/Abstract]

10. Gandini O Celi FS Magnanti M Gazzaniga P Silvestri I Conti B Giuliani L Mentuccia D Agliano AM A rapid, simple, and inexpensive step facilitates RNA extraction from whole blood cells. Lab Invest (79): 1731-2, 1999. [Full Text/Abstract]

11. Celi FS Canettieri G Yarnall DP Burns DK Andreoli M Shuldiner AR Centanni M Genomic characterization of the coding region of the human type II 5''-deiodinase gene. Mol Cell Endocrinol (141): 49-52, 1998. [Full Text/Abstract]

12. Celi FS Silver K Walston J Knowler WC Bogardus C Shuldiner AR Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians. J Clin Endocrinol Metab (80): 2827-9, 1995. [Full Text/Abstract]

13. Walston J Silver K Bogardus C Knowler WC Celi FS Austin S Manning B Strosberg AD Stern MP Raben N et al Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (333): 343-7, 1995. [Full Text/Abstract]