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Clinical Interventions
to Increase Organ Procurement
Fiscal Year 2002 Grantees
| Grantee: |
The
Johns Hopkins University |
| Grant
#: |
1H39OT0013301 |
| Consortium
Members: |
The
Johns Hopkins University Departments of Surgery, Medicine
and Pathology |
| Project
Title: |
Enhanced
Utilization of Extended Criteria Donor Kidneys |
| Description: |
The
goal of this project is to identify criteria that have
predictive value for the performance of extended criteria
donor kidneys after transplantation and validate a model
for evidence-based selection of viable organs. The criteria
will draw from three data sources: donor characteristics,
histopathology, and pulsatile perfusion. The study is
designed to answer fundamental questions about the value
of pulsatile perfusion in resuscitating, preserving,
and interrogating the function of both high and low
risk extended criteria donor kidneys. |
| Grantee:
|
Health
Services Foundation |
| Grant
#: |
1H39OT0013501 |
| Consortium
Members: |
University
of Alabama at Birmingham, University of California,
San Francisco, Life
Connection of Ohio |
| Project
Title: |
Multi-center
Trial to Increase Recovery of Donor Organs through Improved
Evaluation of Donor Hearts and Aggressive Donor Management |
| Description: |
This
multi-center trial is intended to determine the accuracy
of echocardiography in donor evaluation and to evaluate
the efficacy of aggressive donor management. Outcomes
will be determined by organ utilization rates, donor
ejection fraction, and cardiac output and left ventricular
stroke work. |
| Grantee:
|
New
England Organ Bank |
| Grant
#: |
1H39OT00123-01 |
| Consortium
Members: |
New
England Organ Bank, University of Michigan, Gift of
Life Michigan, Life Choice Donor Services |
| Project
Title: |
The
Impact of an Expedited Allocation System and Pulsatile
Preservation upon the Transplantation of Kidneys from
Expanded Criteria Donors |
| Description: |
The
purpose of this project is to increase the number of
kidneys transplanted from expanded criteria donors and
determine whether specific pre-transplant characteristics
of expanded donor kidneys and the recently adopted OPTN
expedited allocation system will influence kidney acceptance
rates, reduce discard rates, and increase the opportunity
for kidney transplantation. |
| Grantee:
|
Indiana
Organ Procurement Organization |
| Grant
#: |
1H39OT00134-01 |
| Consortium
Members: |
Indiana
Organ Procurement Organization, the Ohio State University,
Grant Medical Center, Metrohealth, the Aultman Health
Foundation, Parkview Hospital, Methodist Hospital, Clarian
Health |
| Project
Title: |
Effectiveness
of High-Frequency Chest Wall Oscillation to Improve
the Quantity and Quality of Brain-dead Heart-beating
Donor Lungs Recovered for Transplantation |
| Description: |
The
purpose of this experimental study is to critically
evaluate the effect of adding high frequency chest wall
oscillation to the routine donor management protocol
in the care of brain dead heart beating donors. The
outcomes of quantity and quality of donor lungs will
be evaluated. |
| Grantee:
|
University
of Miami |
| Grant
#: |
6H39OT00126-01-01 |
| Consortium
Members: |
University
of Miami, University of Miami Organ Procurement Organization |
| Project
Title: |
Donor
Treatment with “The Link™” to Improve
Airway clearance and Increase
the Number of Lungs recovered for Transplantation |
| Description: |
Application
proposes to treat organ donor patients during donor
management with “The Link™”, a device
using an inflatable vest to deliver oscillating compressive
forces over the chest to dislodge mucous and secretions
in donor lungs. This intervention is expected to improve
donor airway clearance; improve lung function as measured
by objective parameters; and increase the yield of donor
lungs recovered for transplantation, as compared to
donors in the non-intervention group. |
Fiscal
Year 2003 Grantees
| Grantee:
|
University
of Pittsburgh |
| Grant
#: |
R38OT01243 |
| Consortium
Members: |
University
of Pittsburgh School of the Health Sciences, Children’s
Hospital of Pittsburgh, UPMC Presbyterian Hospital,
UPMC Shadyside Hospital, University of Cincinnati, Case
Western Reserve University |
| Project
Title: |
Donors
after Cardiac Death Validating Identification Criteria |
| Description: |
This
project will validate identification criteria that will
accurately recognize potential donors after cardiac
death (DCD). It will also look at post transplant data
from DCD donors and validate the current criteria being
used in regard to DCD donors. Study personnel will identify
patients who are undergoing withdrawal of life sustaining
treatments (LST) and obtain demographic characteristics,
physiological data, note the type of LST being delivered
and withdrawn as well as the palliative medication delivered. |
| Grantee:
|
University
of Miami |
| Grant
#: |
R38OT01367 |
| Consortium
Members: |
University
of Miami-Diabetes Research Institute, Medical College
of Georgia, New Jersey Organ and Tissue Sharing Network,
Lifepoint, Inc., Translife |
| Project
Title: |
The
Use of Perfluorinated Hydrocarbons during Pancreas Procurement
to Improve Utilization of Cadaveric Marginal and Non-Heart
Beating Donor Organs for Clinical Islet Transplantation |
| Description: |
This
project will test whether marginal pancreata from non-heart
beating cadaveric donors with long ischemic times and
whose age is greater than fifty can be utilized for
clinical islet transplantation. The proposed project
includes the training of OPO collaborators in this methodology
for the preservation and transport of perfluorocarbon
(PFC) cultured pancreata utilizing sufficient organs
to establish significance. The field-testing of this
intervention at collaborating OPO centers will establish
replicability of the procedure on a larger scale. |
| Grantee:
|
University
of Pittsburgh |
| Grant
#: |
R38OT1300 |
| Consortium
Members: |
University
of Pittsburgh, University of Texas at Houston, LifeGift,
CORE |
| Project
Title: |
Hemoadsorption
to Improve Organ Donor Recovery |
| Description: |
This
purpose of this grant is to determine whether short-term
attenuation of the inflammatory response using CytoSorb
can reduce pre-explanation organ dysfunction and thereby
improve organ recovery in brain-dead organ donors. The
goals of the project are to reduce circulating cytokine
levels in potential organ donors, improve organ function
in those donors and to increase organ recovery per donor. |
| Grantee:
|
Trustees
of Columbia University |
| Grant
#: |
R38OT01301
|
| Consortium
Members: |
Columbia
University |
| Project
Title: |
Hypothermic
Machine Preservation of Liver Grafts for Transplantation |
| Description: |
The
aim of this project is to establish the efficacy of
continuous hypothermic machine preservation (HMP) in
liver transplantation. The hypothesis is that HMP will
increase the utilization of existing cadaver livers
by improving pretransplant assessment of the graft,
increasing the quality of preservation, and permitting
ex situ pharmacologic manipulation. |
| Grantee:
|
The
Children’s Hospital |
| Grant
#: |
R38OT01314 |
| Consortium
Members: |
The
Children’s Hospital, Denver, Donor Alliance |
| Project
Title: |
Infant
Heart Transplantation from Non-Heart Beating Donors:
A Strategy to Reduce Waiting Mortality |
| Description: |
This
project intends to increase infant cardiac donors as
a way to reduce waiting time and waiting mortality by
implementing a non-heart beating donor protocol for
cardiac donation in infants and children. Data from
the population of patients receiving a donor organ from
a non-heart beating donor and from a traditional heart
beating donor will be collected. Outcome measures of
waiting mortality and waiting time will be compared
to local data contained within the program transplant
database and compared with national data contained within
the SRTRD |
Fiscal
Year 2004 Grantees
| Grantee:
|
Carolina
Donor Services |
| Grant
#: |
R38OT03593 |
| Consortium
Members: |
Carolina
Donor Services, University of Carolina, Chapel Hill |
| Project
Title: |
Ex-Vivo
Evaluation of Human Lungs from Non-heart Beating Donors
for Transplant |
| Description: |
This
project will implement an established system to perfuse
and ventilate human lungs ex-vivo, to assess gas exchange
and other parameters of function of lungs retrieved
from non heart beating donors |
Fiscal
Year 2007 Grantees
| Grantee:
|
University
of Pittsburgh |
| Grant
#: |
R38OT08758 |
| Consortium
Members: |
University
of Pittsburgh, Center for Organ Recovery and Education,
University of Michigan Gift of Life |
| Project
Title: |
Development
and Dissemination of a Rapid Response System for Uncontrolled
Donation after Cardiac Death (UDCD) |
| Description: |
This
project will create a program to successfully implement
organ transplantation from uncontrolled donation after
cardiac death donors and demonstrate the ability to
rapidly disseminate an UDCD program to another institution. |
| Grantee:
|
New
York City Health and Hospitals Corporation |
| Grant
#: |
R38OT08761 |
| Consortium
Members: |
New
York City Health and Hospitals Corporation, New York
Organ Donor Network, New York University School of Medicine,
New York City Emergency Medical Services |
| Project
Title: |
Opportunities
for Organ Donation: Expanding the Right to Donate Organs
Following Uncontrolled Circulatory Determination of
Death |
| Description: |
This
project is based upon the sparse organ donation opportunities
to date for pre-hospital uncontrolled donation after
cardiac death (UDCD). A consortium of Bellevue Hospital
Center, the New York City Emergency Medical Services
and The New York Organ Donor Network propose to enhance
public and professional education, disseminate best
practices, and monitor and evaluate donation efforts
from UDCD while adding preparation for organ donation
to the end of standard cardiac resuscitation protocols |
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