| | This journal provides immediate access to some articles. Perspective When Segregation Hangs by a Thread Giovanni Bosco PLoS Genet. 2009 February; 5(2): e1000371. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000371.PMCID: PMC2631148 Conservation and Convergence of Colour Genetics: MC1R Mutations in brown Cavefish Nicholas I. Mundy PLoS Genet. 2009 February; 5(2): e1000388. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000388.PMCID: PMC2638015 Review Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers Johanna Jakobsdottir, Michael B. Gorin, Yvette P. Conley, Robert E. Ferrell, and Daniel E. Weeks PLoS Genet. 2009 February; 5(2): e1000337. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000337.PMCID: PMC2629574 Research Articles Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans Jeremy M. Van Raamsdonk and Siegfried Hekimi PLoS Genet. 2009 February; 5(2): e1000361. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000361.PMCID: PMC2628729 Adaptations to Submarine Hydrothermal Environments Exemplified by the Genome of Nautilia profundicola Barbara J. Campbell, Julie L. Smith, Thomas E. Hanson, Martin G. Klotz, Lisa Y. Stein, Charles K. Lee, Dongying Wu, Jeffrey M. Robinson, Hoda M. Khouri, Jonathan A. Eisen, and S. Craig Cary PLoS Genet. 2009 February; 5(2): e1000362. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000362.PMCID: PMC2628731 hnRNP I Inhibits Notch Signaling and Regulates Intestinal Epithelial Homeostasis in the Zebrafish Jing Yang, Chin Yee Chan, Bo Jiang, Xueyuan Yu, Guo-Zhang Zhu, Yiping Chen, John Barnard, and Wenyan Mei PLoS Genet. 2009 February; 5(2): e1000363. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000363.PMCID: PMC2629577 Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair Hélène Gaillard, Cristina Tous, Javier Botet, Cristina González-Aguilera, Maria José Quintero, Laia Viladevall, María L. García-Rubio, Alfonso Rodríguez-Gil, Antonio Marín, Joaquín Ariño, José Luis Revuelta, Sebastián Chávez, and Andrés Aguilera PLoS Genet. 2009 February; 5(2): e1000364. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000364.PMCID: PMC2629578 Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae Jennifer K. Lowe, Julian B. Maller, Itsik Pe'er, Benjamin M. Neale, Jacqueline Salit, Eimear E. Kenny, Jessica L. Shea, Ralph Burkhardt, J. Gustav Smith, Weizhen Ji, Martha Noel, Jia Nee Foo, Maude L. Blundell, Vita Skilling, Laura Garcia, Marcia L. Sullivan, Heather E. Lee, Anna Labek, Hope Ferdowsian, Steven B. Auerbach, Richard P. Lifton, Christopher Newton-Cheh, Jan L. Breslow, Markus Stoffel, Mark J. Daly, David M. Altshuler, and Jeffrey M. Friedman PLoS Genet. 2009 February; 5(2): e1000365. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000365.PMCID: PMC2628735 A Gene-Based Linkage Map for Bicyclus anynana Butterflies Allows for a Comprehensive Analysis of Synteny with the Lepidopteran Reference Genome Patrícia Beldade, Suzanne V. Saenko, Nicolien Pul, and Anthony D. Long PLoS Genet. 2009 February; 5(2): e1000366. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000366.PMCID: PMC2629579 Genetic Mechanisms in Apc-Mediated Mammary Tumorigenesis Mari Kuraguchi, Nana Yaw Ohene-Baah, Dmitriy Sonkin, Roderick Terry Bronson, and Raju Kucherlapati PLoS Genet. 2009 February; 5(2): e1000367. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000367.PMCID: PMC2629572 Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML) Shamil R. Sunyaev, Alexey Lugovskoy, Kenneth Simon, and Leonid Gorelik PLoS Genet. 2009 February; 5(2): e1000368. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000368.PMCID: PMC2629573 Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D Sreeram V. Ramagopalan, Narelle J. Maugeri, Lahiru Handunnetthi, Matthew R. Lincoln, Sarah-Michelle Orton, David A. Dyment, Gabriele C. DeLuca, Blanca M. Herrera, Michael J. Chao, A. Dessa Sadovnick, George C. Ebers, and Julian C. Knight PLoS Genet. 2009 February; 5(2): e1000369. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000369.PMCID: PMC2627899 Loss of Myotubularin Function Results in T-Tubule Disorganization in Zebrafish and Human Myotubular Myopathy James J. Dowling, Andrew P. Vreede, Sean E. Low, Elizabeth M. Gibbs, John Y. Kuwada, Carsten G. Bonnemann, and Eva L. Feldman PLoS Genet. 2009 February; 5(2): e1000372. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000372.PMCID: PMC2631153 A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia Anna C. Need, Dongliang Ge, Michael E. Weale, Jessica Maia, Sheng Feng, Erin L. Heinzen, Kevin V. Shianna, Woohyun Yoon, Dalia Kasperavičiūtė, Massimo Gennarelli, Warren J. Strittmatter, Cristian Bonvicini, Giuseppe Rossi, Karu Jayathilake, Philip A. Cola, Joseph P. McEvoy, Richard S. E. Keefe, Elizabeth M. C. Fisher, Pamela L. St. Jean, Ina Giegling, Annette M. Hartmann, Hans-Jürgen Möller, Andreas Ruppert, Gillian Fraser, Caroline Crombie, Lefkos T. Middleton, David St. Clair, Allen D. Roses, Pierandrea Muglia, Clyde Francks, Dan Rujescu, Herbert Y. Meltzer, and David B. Goldstein PLoS Genet. 2009 February; 5(2): e1000373. Published online 2009 February 6. doi: 10.1371/journal.pgen.1000373.PMCID: PMC2631150 A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma Renee D. Read, Webster K. Cavenee, Frank B. Furnari, and John B. Thomas PLoS Genet. 2009 February; 5(2): e1000374. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000374.PMCID: PMC2636203 The Individual Blood Cell Telomere Attrition Rate Is Telomere Length Dependent Katarina Nordfjäll, Ulrika Svenson, Karl-Fredrik Norrback, Rolf Adolfsson, Per Lenner, and Göran Roos PLoS Genet. 2009 February; 5(2): e1000375. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000375.PMCID: PMC2633043 Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels Shondra M. Pruett-Miller, David W. Reading, Shaina N. Porter, and Matthew H. Porteus PLoS Genet. 2009 February; 5(2): e1000376. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000376.PMCID: PMC2633050 Accumulation of Rhodopsin in Late Endosomes Triggers Photoreceptor Cell Degeneration Yashodhan Chinchore, Amitavo Mitra, and Patrick J. Dolph PLoS Genet. 2009 February; 5(2): e1000377. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000377.PMCID: PMC2633617 Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis Arne S. Schaefer, Gesa M. Richter, Birte Groessner-Schreiber, Barbara Noack, Michael Nothnagel, Nour-Eddine El Mokhtari, Bruno G. Loos, Søren Jepsen, and Stefan Schreiber PLoS Genet. 2009 February; 5(2): e1000378. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000378.PMCID: PMC2632758 Steroid Hormone Control of Cell Death and Cell Survival: Molecular Insights Using RNAi Suganthi Chittaranjan, Melissa McConechy, Ying-Chen Claire Hou, J. Douglas Freeman, Lindsay DeVorkin, and Sharon M. Gorski PLoS Genet. 2009 February; 5(2): e1000379. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000379.PMCID: PMC2632862 ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana Jean-Baptiste Vannier, Annie Depeiges, Charles White, and Maria Eugenia Gallego PLoS Genet. 2009 February; 5(2): e1000380. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000380.PMCID: PMC2632759 Sporadic Infantile Epileptic Encephalopathy Caused by Mutations in PCDH19 Resembles Dravet Syndrome but Mainly Affects Females Christel Depienne, Delphine Bouteiller, Boris Keren, Emmanuel Cheuret, Karine Poirier, Oriane Trouillard, Baya Benyahia, Chloé Quelin, Wassila Carpentier, Sophie Julia, Alexandra Afenjar, Agnès Gautier, François Rivier, Sophie Meyer, Patrick Berquin, Marie Hélias, Isabelle Py, Serge Rivera, Nadia Bahi-Buisson, Isabelle Gourfinkel-An, Cécile Cazeneuve, Merle Ruberg, Alexis Brice, Rima Nabbout, and Eric LeGuern PLoS Genet. 2009 February; 5(2): e1000381. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000381.PMCID: PMC2633044 Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates Elizabeth M. H. Tank and Heather L. True PLoS Genet. 2009 February; 5(2): e1000382. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000382.PMCID: PMC2633047 HECTD2 Is Associated with Susceptibility to Mouse and Human Prion Disease Sarah E. Lloyd, Emma G. Maytham, Hirva Pota, Julia Grizenkova, Eleni Molou, James Uphill, Holger Hummerich, Jerome Whitfield, Michael P. Alpers, Simon Mead, and John Collinge PLoS Genet. 2009 February; 5(2): e1000383. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000383.PMCID: PMC2633041 A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic Bo Eskerod Madsen and Sharon R. Browning PLoS Genet. 2009 February; 5(2): e1000384. Published online 2009 February 13. doi: 10.1371/journal.pgen.1000384.PMCID: PMC2633048 Ploidy Reductions in Murine Fusion-Derived Hepatocytes Andrew W. Duncan, Raymond D. Hickey, Nicole K. Paulk, Andrew J. Culberson, Susan B. Olson, Milton J. Finegold, and Markus Grompe PLoS Genet. 2009 February; 5(2): e1000385. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000385.PMCID: PMC2636893 The Pattern of R2 Retrotransposon Activity in Natural Populations of Drosophila simulans Reflects the Dynamic Nature of the rDNA Locus Jun Zhou and Thomas H. Eickbush PLoS Genet. 2009 February; 5(2): e1000386. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000386.PMCID: PMC2637433 Poly (ADP-Ribose) Polymerase 1 Is Required for Protein Localization to Cajal Body Elena Kotova, Michael Jarnik, and Alexei V. Tulin PLoS Genet. 2009 February; 5(2): e1000387. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000387.PMCID: PMC2637609 Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair Daniel Lucas, Beatriz Escudero, José Manuel Ligos, Jose Carlos Segovia, Juan Camilo Estrada, Gloria Terrados, Luis Blanco, Enrique Samper, and Antonio Bernad PLoS Genet. 2009 February; 5(2): e1000389. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000389.PMCID: PMC2638008 Turnover of Sex Chromosomes in the Stickleback Fishes (Gasterosteidae) Joseph A. Ross, James R. Urton, Jessica Boland, Michael D. Shapiro, and Catherine L. Peichel PLoS Genet. 2009 February; 5(2): e1000391. Published online 2009 February 20. doi: 10.1371/journal.pgen.1000391.PMCID: PMC2638011 Gene Dosage Effects of the Imprinted Delta-Like Homologue 1 (Dlk1/Pref1) in Development: Implications for the Evolution of Imprinting Simao Teixeira da Rocha, Marika Charalambous, Shau-Ping Lin, Isabel Gutteridge, Yoko Ito, Dionne Gray, Wendy Dean, and Anne C. Ferguson-Smith PLoS Genet. 2009 February; 5(2): e1000392. Published online 2009 February 27. doi: 10.1371/journal.pgen.1000392.PMCID: PMC2640098 Mutation of the Mouse Syce1 Gene Disrupts Synapsis and Suggests a Link between Synaptonemal Complex Structural Components and DNA Repair Ewelina Bolcun-Filas, Robert Speed, Mary Taggart, Corinne Grey, Bernard de Massy, Ricardo Benavente, and Howard J. Cooke PLoS Genet. 2009 February; 5(2): e1000393. Published online 2009 February 27. doi: 10.1371/journal.pgen.1000393.PMCID: PMC2640461 The D4Z4 Macrosatellite Repeat Acts as a CTCF and A-Type Lamins-Dependent Insulator in Facio-Scapulo-Humeral Dystrophy Alexandre Ottaviani, Sylvie Rival-Gervier, Amina Boussouar, Andrea M. Foerster, Delphine Rondier, Sabrina Sacconi, Claude Desnuelle, Eric Gilson, and Frédérique Magdinier PLoS Genet. 2009 February; 5(2): e1000394. Published online 2009 February 27. doi: 10.1371/journal.pgen.1000394.PMCID: PMC2639723 Chordin Is a Modifier of Tbx1 for the Craniofacial Malformations of 22q11 Deletion Syndrome Phenotypes in Mouse Murim Choi and John Klingensmith PLoS Genet. 2009 February; 5(2): e1000395. Published online 2009 February 27. doi: 10.1371/journal.pgen.1000395.PMCID: PMC2640462 A Systems Approach Reveals Regulatory Circuitry for Arabidopsis Trichome Initiation by the GL3 and GL1 Selectors Kengo Morohashi and Erich Grotewold PLoS Genet. 2009 February; 5(2): e1000396. Published online 2009 February 27. doi: 10.1371/journal.pgen.1000396.PMCID: PMC2642726 Corrections Correction: A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels Trevor C. Y. Kwok, Kwokyin Hui, Wojciech Kostelecki, Nicole Ricker, Guillermo Selman, Zhong-Ping Feng, and Peter John Roy PLoS Genet. 2009 February; 5(2): 10.1371/annotation/c38f7645-c9d8-4371-b363-5a9099c75e83. Published online 2009 February 24. doi: 10.1371/annotation/c38f7645-c9d8-4371-b363-5a9099c75e83.PMCID: PMC2665012 Corrects: Trevor C. Y. Kwok, et al. A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels. PLoS Genet. 2008 May; 4(5): e1000067. Correction: A Position Effect on the Heritability of Epigenetic Silencing Jaswinder Singh, Michael Freeling, and Damon Lisch PLoS Genet. 2009 February; 5(2): 10.1371/annotation/dd58c52f-161d-4a3f-b560-c9fd78307f85. Published online 2009 February 13. doi: 10.1371/annotation/dd58c52f-161d-4a3f-b560-c9fd78307f85.PMCID: PMC2665015 Corrects: Jaswinder Singh, et al. A Position Effect on the Heritability of Epigenetic Silencing. PLoS Genet. 2008 October; 4(10): e1000216. Correction: LINE Retrotransposon RNA Is an Essential Structural and Functional Epigenetic Component of a Core Neocentromeric Chromatin Anderly C. Chueh, Emma L. Northrop, Kate H. Brettingham-Moore, K. H. Andy Choo, and Lee H. Wong PLoS Genet. 2009 February; 5(2): 10.1371/annotation/3b497aec-b7d3-442e-9086-751251f649dd. Published online 2009 February 12. doi: 10.1371/annotation/3b497aec-b7d3-442e-9086-751251f649dd.PMCID: PMC2665016 Corrects: Anderly C. Chueh, et al. LINE Retrotransposon RNA Is an Essential Structural and Functional Epigenetic Component of a Core Neocentromeric Chromatin. PLoS Genet. 2009 January; 5(1): e1000354. |