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University of Vermont

University of Vermont

General Clinical Research Center
Fletcher Allen Health Care Center
Baird 7, MCHV Campus
Burlington, VT 05401

Grant No. M01 RR00109

Special Assays, Services, or Tests

D₂O (deuterium) dilution technique for estimating total body water and body composition

Doubly labeled water

Immunoassays: C-peptide, cortisol, glucagon, insulin, prolactin, GH, cotinine, nicotine, leptin

Isolation of peripheral blood mononuclear cells

Mass spectrometry assays including stable isotopomer analysis of CO₂, body water, amino acids, sugars, and fatty acids

Online analyses of whole blood glucose, lactate, plasma CO₂

Special Resources, Instruments, or Services

Bicycle ergometers
Bioelectrical impedance analyzers for estimating body composition in children and adults
Continuous blood pressure monitoring
Dual-energy X-ray absorption machine for pediatric and adult bone density and body composition analyses
EKG for monitoring subjects at rest and during exercise
Exercise treadmills
Food intake analysis system
Fuel cell O₂ analyzers
GC/MS, IR/MS, LC/MS
Hand-warming devices for arterialization of venous blood
HPLC

Human physiology lab, exercise testing, body composition analysis
Indirect calorimetry facilities
Infrared CO₂ analyzers
Insulin clamp expertise
Nutritional intervention, monitoring, and education
Pediatric total-body electrical conductivity analyzer for measurement of infant body composition
Pneumotachygraphs
SensorMedics Deltatracs
Tissots
Underwater weighing facility with helium analyzer for lung volumes

Major Areas of Investigation

Cardiac Disease: Cardiac function in heart failure; cardiac rehabilitation.

Clinical Pharmacology: Phase I and II drug trials.

Gastroenterology: Regional enteritis; immune studies of chronic active hepatitis; effect of diet on colonic mucosa.

Gynecology: Estrogen metabolism in postmenopausal women; prostaglandin synthetase inhibitors; modulating role of body composition on reproductive hormones; effect of estrogen on cardiac function.

Metabolism: Obesity; hypoglycemia; diabetes mellitus; exercise; genetic studies in multiple endocrine neoplasia; catecholamine metabolism; regulation of energy expenditure; ketoacid effects on amino acid metabolism in insulin-dependent diabetes mellitus; protein metabolism-regulation of protein synthesis and degradation by hormones and substrates; interactions between diabetes and thromboses.

Neurology: Therapeutic intervention in idiopathic chronic polyneuropathy; DNA damage in muscular dystrophy, polymyositis, amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases.

Nutrition: Pathophysiology of weight gain; obesity; diet-induced thermogenesis; dietary fiber; nutrition support; effect of dietary fiber on estrogen metabolism; effects of vitamin K₁ in women of childbearing age; low-calorie versus low-fat diets; effects of tryptophan depletion on behavior.

Oncology: Clinical trials of chemotherapeutic agents and immunotherapy; intraperitoneal IL-2 and lymphokine-activated killer cells in recurrent ovarian carcinoma; lymphatic scintigraphy.

Pediatrics: Hormonal mechanisms of pubertal growth; relation of age-related decline in growth hormone to muscle loss and fat accumulation; treatment of obesity with growth hormone; testing for prediabetes.

Psychiatry: Bulimia and anorexia nervosa: treatment comparison; stimulant and alcohol interactions; mecamylamine model of dementia; effect of nicotine administration on cognitive functions in Alzheimer's disease; genetic basis of aggression in children; substance abuse; drug discrimination.

Surgery: Subcutaneous heparin versus oral warfarin in patients undergoing unilateral elective knee or hip replacement surgery.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Laurie S. Lester, Ph.D.
802-847-3733; Fax: 802-847-1190
E-mail: laurie.lester@uvm.edu

Program Director
Richard A. Galbraith, M.D., Ph.D.
802-847-2777; Fax: 802-847-5562
E-mail: richard.galbraith@uvm.edu

Principal Investigator
Frederick C. Morin, III, M.D.
802-656-2156; Fax: 802-656-8577
E-mail: Frederick.Morin@uvm.edu

Associate Program Director
Philip A. Ades, M.D.
802-656-4514; Fax: 802-847-5371
E-mail: philip.ades@uvm.edu

Associate Program Director
Naomi K. Fukagawa, M.D., Ph.D.
802-656-4403; Fax: 802-847-5371
E-mail: naomi.fukagawa@uvm.edu

Research Subject Advocate
Ira Bernstein, M.D.
802-847-0433; Fax: 802-847-4306
E-mail: ira.bernstein@uvm.edu

GCRC Advisory Committee Chairperson
Marjorie C. Meyer, M.D.
802-847-5066; Fax: 802-847-2360
E-mail: marjorie.meyer@uvm.edu

Biochemistry Core Laboratory Manager
Susan S. Lang, B.S.
802-847-5334; Fax: 802-847-5371
E-mail: susan.lang@uvm.edu

Mass Spectrometry Core Laboratory Director
Dwight E. Matthews, Ph.D.
802-656-8114; Fax: 802-847-5371
E-mail: dwight.matthews@uvm.edu

Physiology Core Laboratory Coordinator
Catherine M. Gurgol, M.S.
802-847-4738; Fax: 802-847-5371
E-mail: catherine.gurgol@vtmednet.org

Nurse Manager
Sandra A. True, R.N., B.S.
802-847-5098; Fax: 802-847-5371
E-mail: sandra.true@vtmednet.org

Bionutrition Research Manager
Susan E. Ridzon, M.S., R.D.
802-847-4730; Fax: 802-847-5371
E-mail: susan.ridzon@vtmednet.org

Biostatistician
Janice Bunn, Ph.D.
802-656-8193; Fax: 802-656-0632
E-mail: janice.bunn@uvm.edu

Informatics Core Manager
Diantha B. Howard, M.S.
802-847-5033; Fax: 802-847-5371
E-mail: diantha.howard@uvm.edu