![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|
Quick Links NCRR and the 2009 Recovery Act
|
New YorkClinical Research Resources Links ON THIS PAGE: The Feinstein Institute for Medical Research General Clinical Research Center Web site: http://www.nslij.com/body.cfm?id=2737&oTopID=2581&PLinkID=5096 Grant No. M01 RR018535 Special Assays, Services, or TestsBiorepository core and tissue donation program: Tissues: site initiation (find a source for samples), collection; access to existing samples; Biorepository (stores biological fluids long-term or short-term): plasma, serum, DNA Imaging core: PET scans, MRI scans, fMRI Molecular biology and immunology core: DNA synthesis of custom oligonucleotides <120 bp in length; standard oligonucleotides; single fluorescently labeled oligonucleotide; double fluorescently labeled oligonucleotide; DNA sequencing; protein sequencing; protein synthesis, 15-20 amino acid residue oligomers; real-time or quantitative PCR; confocal microscope; Hewlett-Packard matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrophotometer; gas chromatograph/mass spectrophotometer; ProteinChip protein analysis system; Sorvall centrifuges, scintillation counter; Bio-Rad gel system, lyophilizer, Shimadzu biospectrophotometer, Savant; automated speed-vac system, dark room, radioactive fume hood; flow cytometry; cytokine ELISA; RNA i solation; silver nitrate immunoperoxidase (SNIP) analysis Major Areas of InvestigationCardiology: Cardiac surgery; thyroid hormone therapy. Endocrinology: Diabetes. Gastroenterology: Inflammatory bowel disease. Hematology: Diamond-Blackfan. Immunology: Chronic lymphomic leukemia; rheumatoid arthritis. Molecular Genetics: Rheumatoid arthritis; systemic lupus erythematosus; cancer. Nephrology: Congenital uropathies; diarrhea-related hemolytic uremic syndrome (D-HUS). Neuropsychiatry: Parkinson's disease; Alzheimer's disease. Psychiatry: Schizophrenia; depression; post-traumatic disorder; bipolar disorder; autism; obsessive compulsive disorder. Sepsis: Cytokine responses; HMGB1; cholinergic anti-inflammatory pathway. Urology: Cystitis; urinary incontinence. Vascular Disease: Abdominal aortic aneurysm; peripheral vascular disease; carotid endardectomy. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Manager Program Director Principal Investigator Associate Program Director Associate Program Director Associate Program Director Assistant Program Director Assistant Program Director Research Subject Advocate GCRC Advisory Committee Chairperson Nurse Manager Biostatistics Director Informatics Manager Molecular Biology and Immunology Core Director Biorepository and Tissue Donation Program Director Mount Sinai School of Medicine General Clinical Research Center Web site: www.mssm.edu/gcrc/index.shtml Grant No. M01 RR00071 Special Assays, Services, or TestsDNA facility: Molecular mutation identification by DNA sequence analysis; direct mutation detection; polymerase chain reaction amplification; restriction enzyme digestion, allele-specific oligonucleotide hybridization; linkage analysis; Southern hybridization analysis; polymorphism analysis; DNA isolation and banking; establishment of immortalized cell lines Major Areas of InvestigationEndocrinology: Role of insulin in modulating responsiveness to androgens in ovarian dysfunction; evaluation of ethnic factors influencing bone mass in female population. Genetic Diseases: Molecular basis of phenotypic variation in Fabry's and Gaucher's diseases; therapy of inborn errors of metabolism (including enzyme deficiencies, amino acid disorders, lipid storage diseases) by dietary, cofactor, transplantation, enzyme replacement, and recombinant DNA approaches; natural history of inborn errors of metabolism and other genetic diseases (such as Niemann-Pick disease). Geriatrics: Drug metabolism; endogenous formation of advanced glycation end products (AGEs) in diabetes. Hematology: Growth and development in children with hemophilia; beta-globin disorders. Internal Medicine: Determinants of vasodilator response in heart failure; effect of lowering cholesterol on thrombotic markers; thrombus formation; lead mobilization during pregnancy and lactation in young urban women. Neurology: Therapy of parkinsonism, myoclonus, dysautonomia, and seizure disorders; HIV dementia; peptide-T in HIV-positive patients. Pediatrics: Immunopathogenic mechanisms of food hypersensitivity in children with atopic dermatitis; cow milk-induced hypersensitivities; peanut hypersensitivity. Psychiatry: Role of glucose metabolism, cholinergic neurotransmitters in memory function in Alzheimer's disease; biochemical alterations in schizophrenia and schizophrenia spectrum disorders; post-traumatic stress disorder; major depression; panic and generalized anxiety disorders; autism and autistic spectrum disorders; obsessive-compulsive, dissociative, and impulse control disorders. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Director Program Director Principal Investigator Associate Program Director Associate Program Director Associate Program Director GCRC Advisory Committee Chairperson Nursing Director Core Laboratory Director Research Dietician Informatics Director Biostatistician Computer Systems and Informatics Manager State University of New York, Stony Brook General Clinical Research Center Grant No. M01 RR10710 Special Assays, Services, or TestsBiostatistics and informatics Gas chromatography/mass spectrometry is available to measure enrichment of stable isotopes in physiological samples derived from metabolic tracer studies Genetics core laboratory offers genetic testing for well-characterized human genetic disorders. Quality assurance, sample handling and processing, and compliance issues have been established. Isolation and storage of DNA from patient peripheral blood leukocytes; storage and tracking of patient material; assistance with techniques of genetic mutation identification (oligonucleotide primer generation); Epstein-Barr virus (EBV) transformation of lymphocytes for rare human disorders, storage of lymphocytes; DNA sequence analysis Immuno- and radiometric assays for insulin-like growth factors I and II; insulin-like growth factor binding protein1, 2, 3 ; growth hormone, prolactin, catecholamines, dopamine Outreach program to recruit minorities and women Major Areas of InvestigationAging: Regulation of muscle metabolism; effects of GH on immune function. Diabetes: Genetic studies in patients with type 2 diabetes mellitus; role of the kidney in glucose metabolism. Dupuytren's Disease: Medical therapy. Genetics: Hematologic diseases and stroke. HIV Disease: Pathogenesis of the metabolic complications. Metabolism: Regulation of muscle wasting in catabolic illness; regulation of muscle metabolism by insulin and amino acids in normal adults; effects of dietary arginine supplements on metabolism in cancer patients; gut priming in neonatal adaptation to enteral nutrition in micropreemies. Neurology: Neurologic complications and development of novel diagnostic testing for Lyme disease; cognitive dysfunction in multiple sclerosis. Osteoporosis: Development of new therapeutic agents. Psychiatry: Substance abuse and its effects on the brain dopamine system. Renal Failure: Use of anabolic agents in children with chronic renal failure; role of nitric oxide in defense against infection in patients on peritoneal dialysis. Contact InformationFor information about this GCRC and how to access its resources, please contact: Administrative Director Program Director Principal Investigator Associate Program Director Research Subject Advocate GCRC Advisory Committee Chairperson Nurse Manager Core Laboratory Director Biostatistician Data Manager/Epidemiologist Informatics Manager/Core Codirector Outreach Program Director |
![]() |
National Institutes of Health (NIH) Bethesda, Maryland 20892 |
![]() |
Department of Health and Human Services |
![]() |