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ICCVAM Evaluation of the Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay
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2008 LLNA Peer Review Panel Meeting

Peer Review Panel report now available - View PDF document

View information about the 2009 LLNA Peer Panel Meeting

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NICEATM and ICCVAM convened an independent scientific peer review panel meeting on March 4-6, 2008, which was attended by over 50 people from eight countries, representing government, industry, animal welfare interests and international organizations. The Panel, which included experts in the field of dermatology, toxicology, biostatistics, regulatory policy, immunology and veterinary medicine, evaluated modifications and new applications for the LLNA, including:

  • The validation status of three modified LLNA test method protocols that use non-radioactive probe chemicals
  • The validation status of a LLNA limit dose procedure
  • The use of the LLNA to test mixtures, aqueous solutions, and metals (applicability domain for the LLNA)
  • The use of the LLNA to determine potency (potential for allergic contact dermatitis hazard)
  • Revised draft recommended performance standards for the LLNA
 LLNA Peer Panel Meeting Poster

The Panel peer reviewed the draft review documents for each topic and evaluated the extent that established validation and acceptance criteria have been appropriately addressed. The Panel also commented on the extent that the review documents support draft ICCVAM recommendations on proposed test method protocols and uses, and on revised draft LLNA performance standards.

A report of the peer panel meeting is now available on the NICEATM-ICCVAM website. ICCVAM Recommendations on the evaluated methods are expected to be available by fall 2008.

View Federal Register Notice annoucing availability of the Panel's report
(Vol. 73, No. 98, pages 29136-29137, May 20, 2008) [PDF]

View documents reviewed at the meeting

View meeting agenda [PDF]

View biographies of the independent scientific peer review panel [PDF]

Details about the Panel meeting

View Federal Register Notice announcing the meeting
(Vol. 73, No. 5, pp. 1360-1362, January 8, 2008) [PDF]

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