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Volume 4(2);  February 2008
Correspondence
On the Process of Becoming a Great Scientist
Morgan C Giddings
PLoS Comput Biol. 2008 February; 4(2): e33. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040033.
PMCID: PMC2242824
Education
Comprehensive Analysis of Affymetrix Exon Arrays Using BioConductor
Michał J Okoniewski and Crispin J Miller
PLoS Comput Biol. 2008 February; 4(2): e6. Published online 2008 February 29. doi: 10.1371/journal.pcbi.0040006.
PMCID: PMC2323405
Message From ISCB
Getting Started in Biological Pathway Construction and Analysis
Ganesh A Viswanathan, Jeremy Seto, Sonali Patil, German Nudelman, and Stuart C Sealfon
PLoS Comput Biol. 2008 February; 4(2): e16. Published online 2008 February 29. doi: 10.1371/journal.pcbi.0040016.
PMCID: PMC2323403
Review
Computational Methods for Protein Identification from Mass Spectrometry Data
Leo McHugh and Jonathan W Arthur
PLoS Comput Biol. 2008 February; 4(2): e12. Published online 2008 February 29. doi: 10.1371/journal.pcbi.0040012.
PMCID: PMC2323404
Research Articles
Serotonin, Inhibition, and Negative Mood
Peter Dayan and Quentin J. M Huys
PLoS Comput Biol. 2008 February; 4(2): e4. Prepublished online 2007 November 27. Published online 2008 February 1. doi: 10.1371/journal.pcbi.0040004.
PMCID: PMC2222921
Filling-In and Suppression of Visual Perception from Context: A Bayesian Account of Perceptual Biases by Contextual Influences
Li Zhaoping and Li Jingling
PLoS Comput Biol. 2008 February; 4(2): e14. Prepublished online 2007 December 13. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040014.
PMCID: PMC2242827
Predicting the Receptive Range of Olfactory Receptors
Rafi Haddad, Liran Carmel, Noam Sobel, and David Harel
PLoS Comput Biol. 2008 February; 4(2): e18. Published online 2008 February 1. doi: 10.1371/journal.pcbi.0040018.
PMCID: PMC2222922
Microarray Based Diagnosis Profits from Better Documentation of Gene Expression Signatures
Dennis Kostka and Rainer Spang
PLoS Comput Biol. 2008 February; 4(2): e22. Prepublished online 2008 January 2. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040022.
PMCID: PMC2242819
Evolution of Complex Modular Biological Networks
Arend Hintze and Christoph Adami
PLoS Comput Biol. 2008 February; 4(2): e23. Prepublished online 2008 January 2. Published online 2008 February 8. doi: 10.1371/journal.pcbi.0040023.
PMCID: PMC2233666
How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism
Vesa P Hytönen and Viola Vogel
PLoS Comput Biol. 2008 February; 4(2): e24. Prepublished online 2008 January 1. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040024.
PMCID: PMC2242828
Modeling Cancer Progression via Pathway Dependencies
Elena J Edelman, Justin Guinney, Jen-Tsan Chi, Phillip G Febbo, and Sayan Mukherjee
PLoS Comput Biol. 2008 February; 4(2): e28. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040028.
PMCID: PMC2242820
Selective Adaptation in Networks of Heterogeneous Populations: Model, Simulation, and Experiment
Avner Wallach, Danny Eytan, Shimon Marom, and Ron Meir
PLoS Comput Biol. 2008 February; 4(2): e29. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040029.
PMCID: PMC2242821
Stimulus Design for Model Selection and Validation in Cell Signaling
Joshua F Apgar, Jared E Toettcher, Drew Endy, Forest M White, and Bruce Tidor
PLoS Comput Biol. 2008 February; 4(2): e30. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040030.
PMCID: PMC2323406
The Peri-Saccadic Perception of Objects and Space
Fred H Hamker, Marc Zirnsak, Dirk Calow, and Markus Lappe
PLoS Comput Biol. 2008 February; 4(2): e31. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040031.
PMCID: PMC2242822
Synaptic Plasticity Can Produce and Enhance Direction Selectivity
Sean Carver, Eatai Roth, Noah J Cowan, and Eric S Fortune
PLoS Comput Biol. 2008 February; 4(2): e32. Prepublished online 2008 January 9. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040032.
PMCID: PMC2242823
Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens
Daniel Segura, Radhakrishnan Mahadevan, Katy Juárez, and Derek R Lovley
PLoS Comput Biol. 2008 February; 4(2): e36. Prepublished online 2008 January 11. Published online 2008 February 8. doi: 10.1371/journal.pcbi.0040036.
PMCID: PMC2233667
Modeling an Evolutionary Conserved Circadian Cis-Element
Eric R Paquet, Guillaume Rey, and Felix Naef
PLoS Comput Biol. 2008 February; 4(2): e38. Prepublished online 2008 January 11. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040038.
PMCID: PMC2242825
Control of Cation Permeation through the Nicotinic Receptor Channel
Hai-Long Wang, Xiaolin Cheng, Palmer Taylor, J. Andrew McCammon, and Steven M Sine
PLoS Comput Biol. 2008 February; 4(2): e41. Prepublished online 2008 January 14. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040041.
PMCID: PMC2242826
Accurate Structural Correlations from Maximum Likelihood Superpositions
Douglas L Theobald and Deborah S Wuttke
PLoS Comput Biol. 2008 February; 4(2): e43. Prepublished online 2008 January 14. Published online 2008 February 15. doi: 10.1371/journal.pcbi.0040043.
PMCID: PMC2242818
Genome Landscapes and Bacteriophage Codon Usage
Julius B. Lucks, David R. Nelson, Grzegorz R. Kudla, and Joshua B. Plotkin
PLoS Comput Biol. 2008 February; 4(2): e1000001. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000001.
PMCID: PMC2266997
How Protein Stability and New Functions Trade Off
Nobuhiko Tokuriki, Francois Stricher, Luis Serrano, and Dan S. Tawfik
PLoS Comput Biol. 2008 February; 4(2): e1000002. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000002.
PMCID: PMC2265470
Systematic Analysis of Pleiotropy in C. elegans Early Embryogenesis
Lihua Zou, Sira Sriswasdi, Brian Ross, Patrycja V. Missiuro, Jun Liu, and Hui Ge
PLoS Comput Biol. 2008 February; 4(2): e1000003. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000003.
PMCID: PMC2265476
Stochastic Differential Equation Model for Cerebellar Granule Cell Excitability
Antti Saarinen, Marja-Leena Linne, and Olli Yli-Harja
PLoS Comput Biol. 2008 February; 4(2): e1000004. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000004.
PMCID: PMC2265481
The Signaling Petri Net-Based Simulator: A Non-Parametric Strategy for Characterizing the Dynamics of Cell-Specific Signaling Networks
Derek Ruths, Melissa Muller, Jen-Te Tseng, Luay Nakhleh, and Prahlad T. Ram
PLoS Comput Biol. 2008 February; 4(2): e1000005. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000005.
PMCID: PMC2265486
Multi-Scale Simulations Provide Supporting Evidence for the Hypothesis of Intramolecular Protein Translocation in GroEL/GroES Complexes
Ivan Coluzza, Alfonso De Simone, Franca Fraternali, and Daan Frenkel
PLoS Comput Biol. 2008 February; 4(2): e1000006. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000006.
PMCID: PMC2265519
Diminished Self-Chaperoning Activity of the ΔF508 Mutant of CFTR Results in Protein Misfolding
Adrian W. R. Serohijos, Tamás Hegedűs, John R. Riordan, and Nikolay V. Dokholyan
PLoS Comput Biol. 2008 February; 4(2): e1000008. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000008.
PMCID: PMC2265529
Computer-Based Screening of Functional Conformers of Proteins
Héctor Marlosti Montiel Molina, César Millán-Pacheco, Nina Pastor, and Gabriel del Rio
PLoS Comput Biol. 2008 February; 4(2): e1000009. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000009.
PMCID: PMC2265533
A Novel Bayesian DNA Motif Comparison Method for Clustering and Retrieval
Naomi Habib, Tommy Kaplan, Hanah Margalit, and Nir Friedman
PLoS Comput Biol. 2008 February; 4(2): e1000010. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000010.
PMCID: PMC2265534
Sensing and Integration of Erk and PI3K Signals by Myc
Tae Lee, Guang Yao, Joseph Nevins, and Lingchong You
PLoS Comput Biol. 2008 February; 4(2): e1000013. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000013.
PMCID: PMC2265471
Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation
Navin Elango, Seong-Ho Kim, NISC Comparative Sequencing Program, Eric Vigoda, and Soojin V. Yi
PLoS Comput Biol. 2008 February; 4(2): e1000015. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000015.
PMCID: PMC2265638
Statistical Resolution of Ambiguous HLA Typing Data
Jennifer Listgarten, Zabrina Brumme, Carl Kadie, Gao Xiaojiang, Bruce Walker, Mary Carrington, Philip Goulder, and David Heckerman
PLoS Comput Biol. 2008 February; 4(2): e1000016. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000016.
PMCID: PMC2289775
Identification of Synaptic Targets of Drosophila Pumilio
Gengxin Chen, Wanhe Li, Qing-Shuo Zhang, Michael Regulski, Nishi Sinha, Jody Barditch, Tim Tully, Adrian R. Krainer, Michael Q. Zhang, and Josh Dubnau
PLoS Comput Biol. 2008 February; 4(2): e1000026. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000026.
PMCID: PMC2265480
Mouse Cognition-Related Behavior in the Open-Field: Emergence of Places of Attraction
Anna Dvorkin, Yoav Benjamini, and Ilan Golani
PLoS Comput Biol. 2008 February; 4(2): e1000027. Published online 2008 February 29. doi: 10.1371/journal.pcbi.1000027.
PMCID: PMC2265485
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