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This Month in EHP

By Eddy Ball
May 2009

The May 2009 issue of Environmental Health Perspectives (http://www.ehponline.org/) is now available on-line, with a feature story on environmental effects on the microbiota — the vast population of bacteria and other microbes that regulate health in the gut. The issue also includes a discussion of what is called "shotgun" proteomics and new studies of the autoimmune effects of the industrial solvent trichloroethylene (TCE) in mice and humans, non-food sources of bisphenol A (BPA), feminization of wild fish exposed to environmental estrogens, and the potential roles of folate and cysteine in facilitating arsenic methylation in children.

• The Gut Reaction to Environmental Exposures — Examining the complex relationship between flora in the human gastrointestinal tract and the gut’s ability to defend against environmentally linked disease
• Boosting the Signal for Biomarker Discovery with "Shotgun" Proteomics — Probing the potential of advances in omics technologies for streamlining biomarker discovery by narrowing the field of promising candidates for follow-up with targeted immunoassays
• TCE and Autoimmune Disease — Reviewing evidence that TCE is involved in the development of autoimmune disease in mice and humans and calling for additional work in this promising line of research
• BPA Levels in Fasting NHANES Participants — Analyzing data on fasting times in participants in the 2003-2004 National Health and Nutrition Examination Survey (NHANES) that suggest non-food sources of BPA and BPA accumulation in fat or other body tissues
• Environmental Estrogens and Endocrine Disruption in Fish — Estimating associations between feminization of wild fish and concentrations of estrogenic and anti-androgenic chemicals in the rivers where they live that support a multi-causal etiological link
• Tailoring Nutritional Interventions for Children Exposed to Arsenic — Teasing out the differences between arsenic-exposed adults and children in relation to their urinary arsenic metabolites and plasma levels of the nutrients folate, cobalamin, cysteine and homocysteine

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