T-reg and Th17 cells in tissue inflammations

 


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Air date: Wednesday, April 29, 2009, 4:15:00 PM
Category: Immunology
Description: The interests of Vijay Kuchroo and his lab revolve around the function and regulation of the effector and regulatory T cell responses and how they are involved in autoimmune and inflammatory disease. His laboratory pioneered the study of the Th17 lineage and its regulation, and was one of the first to show that IL6+TGFb are the commitment factors for the lineage, whereas IL23 stabilizes the phenotype. They also were among the first to define the reciprocal relationship between induced T-regulatory cells and Th17 cells, defined the factors that affect plasticity of the lineage decisions and conversion between effector T cell lineages. Their recent work on the diversity of the T cell response culminated in the definition of a novel effector T cell lineage termed Th9 and demonstration that the prototypic Th2-related transcription factor cMaf is also involved in development of follicular T-helper and Th17 cells.

Vijay has received many awards and honors for his outstanding work on mechanisms driving central nervous system autoimmunity, including in 2002 The Javits Neuroscience Investigator Award administered by NINDS which is awarded for 7 years to a scientist who has already has made seminal contributions to neurological research and is expected to continue to do cutting edge research for the next 7 years.

Vijay is an engaging speaker who keeps his audience awake and on their toes. Not to miss!

For more information, visit
The Immunology Interest Group
Author: Vijay K. Kuchroo
Runtime: 75 minutes
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CIT File ID: 15071
CIT Live ID: 7457
Permanent link: http://videocast.nih.gov/launch.asp?15071