Engineering Gene Networks: Integrating Synthetic Biology & Systems Biology
Add an upcoming event to your calendar.In this talk, we describe how techniques from nonlinear dynamics and molecular biology can be utilized to model, design and construct synthetic gene regulatory networks. We present examples in which we integrate the development of a theoretical model with the construction of an experimental system. We also discuss the implications of synthetic gene networks for biotechnology, biomedicine and biocomputing.
Additionally, we present integrated computational-experimental approaches that enable construction of quantitative models of gene-protein regulatory networks using expression measurements and no prior information on the network structure or function. We discuss how the reverse-engineered network models, coupled to experiments, can be used:
- (1) to gain insight into the regulatory role of individual genes and proteins in the network,
(2) to identify the pathways and gene products targeted by pharmaceutical compounds, and
(3) to identify the genetic mediators of different diseases.