The FY 2002 appropriation for the NIA is $893,443,000, an increase of $13,482,000 (1.5 percent) from the amount of $879,961,000 requested in the FY 2002 President's budget, and $108,030,000 (13.8 percent) more than the actual obligations of $785,413,000 for FY 2001.
The FY 2002 appropriation provides for 1,481 research project grants at a funding level of $599,392,000. Within this amount, NIA will support 444 competing RPGs. The NIH is again encouraging Institutes to pay at levels close to those recommended by review groups and councils for competing RPGs.
The significant funding increase in FY 2002 will permit continued growth of the NIA's research programs. This will include expanded efforts in such areas as health disparities, Alzheimer's disease, cardiovascular disease, the genetics of aging, and behavioral and social research.
The appropriation provides increases for the Institute's centers and for research and development contract programs. The increase in the career award mechanism includes funding for clinical faculty developing careers in Alzheimer's disease research.
The increase in the Intramural research mechanism will allow NIA's Gerontology Research Center (GRC) to significantly expand its clinical research program as well as expand its work in the areas of cardiovascular research, gene regulation, neurosciences, and genomics. It will also permit funding of several initiatives related to minority health.
The increased level of funding for Research Management and Support will be used for management of NIA's expanding extramural programs, to develop research initiatives with the scientific community, and to improve information technology infrastructure in support of scientific staff.
NIH will submit a Fiscal Year 2003 Budget to Congress at a level requested by the President during the first week in February 2002.
(Contact: Mr. Kevin Laser, FMISB, 301/496-9147)
P.L. 107-50 Small Business Technology Transfer Program Reauthorization Act of 2001On October 15, the President signed H.R. 1860, the Small Business Technology Transfer Program Reauthorization Act of 2001 (P.L. 107-50). The bill initially passed the House on September 24 and the Senate on September 26. The law reauthorizes the Small Business Technology Transfer (STTR) Program, which is a set-aside program designed to support innovative research conducted cooperatively by a small business and a research institution. The STTR program was established by the Small Business Research and Development Enhancement Act of 1992 (Public Law 102-564) and was reauthorized by the Small Business Reauthorization Act of 1997 (Public Law 105-135).
H.R. 717 Muscular Dystrophy Community Assistance, Research and Education Amendments of 2001On February 14, Representative Roger Wicker (R-MS) introduced H.R. 717, Muscular Dystrophy Community Assistance, Research and Education Amendments of 2001 to amend the Public Health Service Act to provide for research and services with respect to various forms of muscular dystrophy (MD). The bill would require the Director of the National Institutes of Health to expand and intensify MD research programs with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Institute of Child Health and Human Development (NICHD); award grants or contracts to public or nonprofit entities for MD research centers of excellence; and provide for donation, collection, and preservation of tissues and genetic materials for such research. It would also direct the Secretary of Health and Human Services (HHS) to establish a Muscular Dystrophy Coordinating Committee to coordinate all federal MD health programs and activities. There is also a provision mandating a contract with the Institute of Medicine to study and report on the impact of, need for, and other issues associated with Centers of Excellence at the NIH. The bill was signed in both the House and Senate on December 4.
S. 1379 Rare Diseases Act of 2001On August 3, Senator Edward Kennedy (D-MA) introduced S. 1379, the Rare Diseases Act of 2001. The Rare Diseases Act of 2001 would provide statutory authorization for the existing NIH Office of Rare Diseases (ORD). The measure would require the Director of ORD to recommend an agenda for research on rare diseases, promote coordination and cooperation among NIH institutes and centers, promote the establishment of a centralized rare diseases information clearinghouse, and serve as the NIH Director's principal advisor on rare diseases. In addition, the bill would establish regional centers of excellence on rare diseases and would require the Director of ORD, in collaboration with the directors of relevant institutes and centers, to fund cooperative agreement and awards for these centers. Support for the centers of excellence would be authorized for up to five years. On October 16, 2001, the Senate Committee on Health, Education, Labor and Pensions ordered the bill to be reported with a technical amendment during a mark-up hearing.
As of November 26, eight Bioterrorism bills were pending and one had become public law. Of the eight pending bills, two are of particular interest to the NIH. On November 14, Senator Christopher J. Dodd (D-CT) introduced S. 1685, the Kids and Terrorism Preparedness Act. The bill would require the Secretary, HHS, in consultation with the Commissioner, FDA, the Director, NIH, and the heads of other appropriate federal agencies, to convene meetings with drug manufacturers and biotechnology and medical device manufacturers to formulate a plan for the development of new and enhanced existing diagnostics, drugs, vaccines, biologics, and medical devices that may be appropriate to prevent and treat children who are exposed to biological, chemical, and radiological agents or nuclear toxins. This act was referred to the Senate Health, Education, Labor, and Pensions Committee (HELP). On November 15, Senator Tom Harkin (D-IA) introduced S. 1706 the Bioterrorism Control and Tracking Act of 2001. The bill would require the Secretary, HHS, to maintain a list of each biological agent and toxin that has the potential to pose a severe threat to public health and safety; establish and enforce safety standards and procedures for possession, use and transfer of such agents; and maintain a national database of the location of such agents and toxins. In addition to the tracking of these agents and toxins, the Secretary would be required to restrict access to these agents to those individuals who need to handle or use them, and would be required to provide for prompt screening of such individuals using criminal, immigration, and national security databases in order to identify restricted persons. This provision could affect NIH visiting scientists
Capitol Hill Briefing/Health Disparities On November 19, Dr. Richard Hodes, Director, NIA; Dr. Yvonne Maddox, Acting Deputy Director, NIH; Dr. John Ruffin, Director, the National Center on Minority Health and Health Disparities (NCMHD); Dr. Duane Alexander, Director, NICHD; and Dr. Griffin Rodgers, Deputy Director, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), briefed the staffs of Senator Edward Kennedy (D-MA); Representatives J.C. Watts (R-OK); Charles Norwood (D-GA); and John Lewis (D-GA) on implementation of P.L. 106-525, the Minority Health and Health Disparities Research and Education Act of 2000, and on current NIH health disparities research at the request of Senator Kennedy.
Meeting with Administration on Aging Assistant Secretary for Aging CarbonellOn October 3, Dr. Richard Hodes and Dr. Judy Salerno met with Ms. Josefina Carbonell. Ms. Carbonell was sworn in as Assistant Secretary for Aging at the DHHS on August 8. The meeting was an informal courtesy visit to discuss collaborative efforts between NIA and the Administration on Aging (AoA), and caregiving research.
Meeting with Ad Hoc Group for Medical Research Funding On October 12, representatives of the Ad Hoc Group for Medical Research Funding met with Dr. Richard Hodes, NIA Director, to discuss ongoing and future NIA research activities.
(Contact Ms. Mary Jo Hoeksema, NIA Legislative Officer, 301/496-0261)
Dr. Rose Maria Li, formerly Chief of the Population and Social Processes Branch and Deputy Director of the Office of Demography in BSR, has accepted a position with Analytical Sciences, Inc. as a Senior Associate in their newly formed Division of Science Management and Research Administration to begin in February 2002. Prior to her departure, Dr. Li completed a two-month assignment in the NIH Office of Communications and Public Liaison, and in the NIH Office of Extramural Programs, to develop guidelines for ensuring the quality of information disseminated by NIH. Dr. Li leaves NIH after nearly ten years of government service.
Dr. Laura Shrestha was appointed the Deputy Associate Director for the Behavioral and Social Research Program effective December 31, 2001. She received her doctoral degree in Demography from the University of Pennsylvania and also has an MA degree in Economics with an emphasis in Public Economics and Administration from the University of Hawaii at Manoa. Formerly, Dr. Shrestha was a Senior Population and Health Specialist in the World Bank where she has held a Number of different positions since 1994. She worked in the main operational division for World Bank projects in Europe and Central Asia and provided technical assistance to governments on a range of topics including disease burden, general epidemiology, identification of "best practice" interventions, and program monitoring, and evaluation. Prior to that, she was a research fellow in Demography of Aging at the University of Pennsylvania's Population Studies Center where she designed and implemented a collaborative research agenda that focused on topics such as demographic and sociological aspects of mortality, migration, disability, and race/ethnic identity.
The Stages of Reproductive Aging Workshop (STRAW), an exploratory workshop held July 22-24, 2001, in Park City, Utah, was co-sponsored by the National Institute on Aging (the Geriatrics Program [GP] and the Biology of Aging Program [BAP]), the National Institute of Child Health and Human Development, the American Society for Reproductive Medicine and the North American Menopause Society. The objective of the meeting was to identify a logical division of the continuum of reproductive aging from the third through the sixth decades to develop a more sensitive, specific, and standardized staging system that could be reliably used in research and clinical settings. There was emphasis on clinical (e.g., menstrual cycle) and endocrinologic (e.g., follicle-stimulating hormone [FSH]) changes that occur as normal reproductive function progresses from the onset of menstruation through advanced reproductive age to complete cessation of ovarian function at menopause. In addition, the timing of other factors, such as vasomotor symptoms and duration or intensity of menstrual flow, were evaluated for relevance in such a staging system. An executive summary of the workshop has been published in three scientific journals-Fertility and Sterility, Journal of Women's Health & Gender-Based Medicine, and Menopause. (Contact: Dr. Sherry Sherman, GP, 301-435-3048).
The Musculoskeletal Aging Biology Workshop, an exploratory workshop, was held October 24, 2001, in Bethesda to present and discuss major areas of research in aging of the musculoskeletal system and skin, to identify areas where gaps exist in our knowledge of age-related changes in these tissues, and to identify areas that appear to be the most fruitful for future research efforts. Four leading investigators in aging skin, cartilage, bone, and muscle summarized the current state of knowledge of aging in these tissues and identified major research questions. Presentations were followed by enthusiastic and extensive discussion of the biology of each tissue and areas that need further research. In addition, research questions in aging with importance to several tissues were identified. These discussions have been summarized and the summary circulated to the participants for comment. (Contact: Dr. Jill Carrington, BAP, 301-496-6402)
The Neuroscience and Neuropsychology of Aging Program (NNA) and the Behavioral and Social Research program (BSR) co-sponsored a two-day advisory meeting on "Racial and Cultural Effects on Measurement of Cognition" on October 31 and November 1, 2001, in Bethesda, Maryland. Approximately 60 clinicians, clinical investigators, basic science investigators, and NIH program staff were invited from both the extramural and intramural communities. The workshop included presentations on constructing and administering culturally relevant measures of cognitive function. Substantive discussion sessions were held on factors that impact cognitive performance, e.g., quality of education, stereotypes, and cohort effects, and on characteristics of culturally relevant cognitive tests/tasks currently in use. (Contacts: Dr. Molly Wagster, NNA, 301-496-9350, e-mail: wagsterm@nia.nih.gov; Dr. Daniel Berch, BSR, 301-594-5942, e-mail: berchd@nia.nih.gov)
NNA sponsored a symposium, "The Latest Links: Genes and Alzheimer's Disease," on November 10 in San Diego, California, during the annual meeting of the Society for Neuroscience. Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, behavior and personality changes, and a decline in cognitive abilities. Studies over the last several years have demonstrated that there is a genetic component, but until this year, just four genes were conclusively known to be associated with the disease. Three genes, amyloid precursor protein, presenilin 1, and presenilin 2 are linked to the early onset form; are autosomal dominant; and account for only a small Number of all AD cases. Studies on the more common late onset form of AD have shown that a fourth gene, the APOE gene, is a susceptibility factor for sporadic late onset AD. Recent reports have suggested that there are additional risk factor genes for late-onset AD, and new AD-related regions in the human genome and gene candidates have been identified that may modify the risk for AD. This exploratory meeting highlighted the newest exciting findings in the genetics of late onset AD. (Contact: Dr. Marilyn Miller, NNA, 301-496-9350)
BAP co-sponsored, with the Progeria Research Foundation, an advisory workshop on the Hutchinson-Gilford Progeria Syndrome, held November 28-29, 2001, in Bethesda to discuss promising experimental approaches to understanding the molecular basis of Hutchinson-Gilford syndrome, a rare syndrome (1/10 million) which resembles some aspects of premature aging. Affected children are small, short, and usually die in their teens of either a heart attack or stroke. Participants developed an agenda for future research. (Contact: Dr. Huber Warner, BAP, 301-496-6402)
A joint BSR, NIH Office of Science Policy and Planning, and National Bureau of Economic Research (NBER)-sponsored "Disability Working Meeting" convened a team of leading scholars for an exploratory discussion of the characteristics, causes and consequences of disability decline in the United States. The discussion touched on past research findings about disability decline and on how to focus future investigations. The goal of the Disability Workshop was to lay the foundation for both follow-up research activities and meetings. One small group will meet to try to resolve technical details for cases in which the evidence on the trends seems to be contradictory. A more formal conference with invited papers will also be planned. (Contact: Dr. Richard Suzman, BSR, 301-496-3138)
The ENU (Ethyl Nitrosourea) Mouse MutagenesisWorkshop (exploratory) was held December 17, 2001, in Bethesda to identify methods or assays for surrogate markers that could be used to screen large Numbers of mutants that might have changes in lifespans or exhibit physiological changes in organ systems that have been found to normally occur with advancing age. Progress reports from Principal Investigators of the ENU Mouse Mutagenesis Project and the Comparative Mouse Genomics Centers Consortium were followed by several presentations from additional investigators on various assays that may have applicability for large scale screening of mutant mice. Presentations were followed by a discussion of the feasibility of each assay and the methodology that would be required for subsequent validation of the assays as surrogate markers. (Contact: Dr. Rebecca Fuldner, BAP, 301-496-6402)
NIA, with the National Institute of Nursing Research (NINR), the National Cancer Institute (NCI), the National Center for Complementary and Alternative Medicine (NCCAM), the Agency for Healthcare Quality and Research (AHRQ), the Health Resources and Services Administration (HRSA), and the Fetzer Institute (Kalamazoo, Michigan) sponsored an exploratory meeting, "Integrative Conference on End of Life Research: Focus on Older Populations" on October 22-23, 2001. Over 60 leading experts in this field attended and helped to define the current state of the science for end of life in older people and identify future directions for NIH research. Papers and prepared commentary were presented on four themes: (1) The Experience of Dying and Spirituality; (2) End of Life Organizations, Settings, and Transitions; (3) Methods and Measurement in End of Life Research; and (4) Ethnical Implications of End of Life Research. The conference organizers are working with the presenters to publish the manuscripts in a special issue of an appropriate leading journal. (Contact: Sidney M. Stahl, 301-402-4156).
The Comparative Biology of Aging Workshop (exploratory), originally scheduled to be held on September 13-14, 2001, has been rescheduled for February 6-7, 2002. The Purpose of the workshop is to gather information on possible comparative biology approaches to the study of aging and on relevant organisms for the comparative study of aging. The workshop is expected to promote interaction between researchers working on aging and those familiar with organisms that can serve as informative models or for informative comparative approaches to the biology of aging. (Contact: Dr. Jill Carrington, BAP, 301-496-6402)
Genetics, Behavior and Aging - BSR's behavior genetics research portfolio includes different genetic approaches relevant to the social and behavioral aspects of aging including behavior genetics, population genetics, and genetic aspects of biodemography. An exploratory meeting to summarize current findings and to explore research directions is being planned in February 2002. The meeting will involve the discussion of commissioned scientific papers on such topics as non-linear dynamic analytic methods for describing complex gene-environment interactions and approaches to measuring environments in aging. The papers will be considered for publication in a special issue of the journal Behavior Genetics for which Dr. Harris in BSR will be the guest editor. (Contact: Dr. Jennifer Harris, BSR, 301-496-3138).
Workshop on the Genetics of Alzheimer's Disease 2002. Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, behavior and personality changes, and a decline in cognitive abilities. Studies over the last several years have demonstrated that there is a genetic component, but until this year, just four genes were conclusively known to be associated with the disease. Three genes-amyloid precursor protein, presenilin 1, and presenilin 2-are linked to the early onset form, are autosomal dominant, and account for only a small Number of all AD cases. Studies on the more common late onset form of AD has shown that a fourth gene, the APOE gene, is a susceptibility factor for sporadic late onset AD. Recent reports have suggested that there are additional risk factor genes for late?onset AD, and new AD-related regions in the human genome and gene candidates have been identified that may modify the risk for AD. This two-day advisory workshop, tentatively scheduled for March 18 and 19, 2002, will explore the status of the field of the genetics of late onset Alzheimer's disease. The following issues will be reviewed: DNA and cell resources presently in genetic research and Alzheimer's Disease Center (ADC) repositories, update and plans for Indian cell bank/ADC focus on genetics of late onset AD, update and plans for databases for sharing of genetics data, collaboration among grantees doing research on late-onset AD, consent and other issues, and interaction with industry. Expected outcomes from the meeting are: Ways of DNA banking that are mutually acceptable to most grantees; Ways of data sharing that are mutually acceptable to most grantees and that will move the field forward quickly; guidance in establishing standards for informed consent and confidentiality; options for industry access to materials if samples have been attained with government funding; and a time line for compliance to agreed standards. (Contact: Dr. Marilyn Miller, NNA, 301-496-9350)
The NNA program of the NIA, the National Institute on Neurological Disorders and Stroke (NINDS), and the National Heart, Lung, and Blood Institute (NHLBI) are co-sponsoring a symposium "Neurocognitive Change after Cardiac Surgery." This workshop, originally scheduled for September 13 and 14, 2001, in Bethesda, Maryland, has been rescheduled for April 4 and 5, 2002. This meeting is considered advisory by the NHLBI. Neurocognitive decline following heart surgery has emerged as an important clinical problem, particularly in the elderly. The workshop is designed to encourage an exchange of ideas and novel strategies among experts in relevant basic and clinical investigations. The meeting will provide an opportunity for investigators from multiple disciplines to review the characteristics of normal cognitive change with age and the cognitive sequelae following cardiac surgery, to review surgical techniques and approaches, and to review methods of neuroprotection in order to determine how best to reduce adverse neurological events following surgery. (Contact: Dr. Molly Wagster, NNA, 301-496-9350, e-mail: wagsterm@nia.nih.gov)
NNA is also co-sponsoring an exploratory conference, "The Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging," on April 10-11, 2002, in San Francisco, California. The conference will be held in conjunction with the annual Cognitive Neuroscience Meeting. Dr. Denise Park, a grantee of NIA, is organizing the conference. Eight of the 13 confirmed speakers are grantees of NIA. Although there are an increasing Number of studies being undertaken that focus on the relationships between cognitive aging and cerebral aging, knowledge concerning the neural basis of cognitive aging has been based on two disciplines that historically have had little contact with each other. The goal of the conference is to develop this area of the cognitive neuroscience of aging by holding a focused conference that permits researchers and their students to exchange ideas and discuss scientific issues in this field. Four sessions are planned during the two-day conference: (1) Noninvasive measures of cerebral aging and their relation to cognitive aging; (2) Cognitive functions: Age-related changes in neural activity; (3) Pathological brain dysfunction and rehabilitation; and (4) Models in cognitive neuroscience of aging. (Contact: Dr. Molly Wagster, NNA, 301-496-9350, e-mail: wagsterm@nia.nih.gov)
BSR and NNA will co-sponsor a an exploratory workshop on the topic of "Cognition in Context" in April 2002. Presentations and plenary discussions will cover, in part, how differences in contextual factors (e.g., socio-cultural, economic, and technological) bring about systematic variation in cognitive functioning and performance. The primary objective of the workshop is to address recent developments in this area that will help shape future research directions. (Contacts: Dr. Daniel Berch, BSR, 301-594-5942; Dr. Molly Wagster, NNA, 301-496-9350).
BSR and NNA are planning an exploratory workshop on Quantitative Reasoning in Older Adults in May 2002. The rationale for this meeting is that a comparatively high level of numerical comprehension and reasoning is required for accurate interpretation of medical and scientific news, wise investment and retirement decisions, and making sound judgments about health-related matters. The workshop will include speakers representing a variety of fields, such as: mathematical cognition, judgment and decision-making, behavioral economics, and cognitive neuroscience. Examples of topics to be covered at the workshop include: numerical processing skills, proportional reasoning, probabilistic reasoning, estimation skills, and math anxiety. A program announcement is expected to follow the workshop. (Contacts: Dr. Daniel Berch, BSR, 301-594-5942; Dr. Molly Wagster, NNA, 301-496-9350)
As a result of discussions at a small exploratory workshop, the Musculoskeletal Biology program, BAP, proposes an advisory workshop on Extracellular Matrix and the Aging Musculoskeletal System and Skin. A workshop with four NIA grantees in the areas of musculoskeletal tissues and skin, entitled Musculoskeletal Aging Biology was held by BAP in October, 2001. Participants in this workshop discussed understudied areas in aging of skin, cartilage, muscle and bone and, further, discussed understudied areas in aging that impinge on all of these tissues. Of several areas of enthusiastic discussion, the area of effects of extracellular matrix changes on cell and tissue health with aging of the skin and musculoskeletal system emerged as a prominent theme that would benefit understanding of aging in all of these tissues. To determine the need for research in this area, a workshop is planned for 2002. The workshop will have approximately 25 participants. It will be structured to assess the current state of knowledge of aging changes in each tissue matrix, to encourage discussion of major issues that cross tissue-specific research areas in aging, and to determine whether specific initiatives to support research in this area would be productive. A report of the meeting, with recommendations, will be synthesized by participants and forwarded to NIA staff. Using these recommendations, staff will determine directions and means of future support for this research to possibly include additional workshops, pilot studies, Exploratory/Developmental Grants (R21 mechanism) or traditional research project grants through program announcements or a request for applications. (Contact: Dr. Jill Carrington, BAP, 301-496-6402)
The Primate Steering Committee Meeting (exploratory) will take place during the spring of 2002. Non-human primates are a valuable model for aging studies due to their close genetic and physiological similarity to humans. Demand on primate colonies in general is increasing, and the form and structure of the primate resources themselves are changing as new concerns are raised about Specific pathogen-free (SPF) animals, genetic backgrounds, and housing of non-human primates. The Purpose of this meeting is to generate discussion on the use of non-human primates in aging research from which we can learn more about the directions in which such research is moving, resources that would facilitate such research, and limitations researchers are now encountering. (Contact: Dr. Nancy Nadon, BAP, 301-496-6402)
The Primate Aging Database Steering Committee Meeting (exploratory) will occur during the spring of 2002. This group of intramural investigators and extramural scientists has met three times to date during the development of the Primate Aging Database (PAD). PAD includes data on biomarkers, primarily blood chemistry and body composition parameters, from multiple non-human primate species. It is designed to be used by biogerontologists looking for biomarkers of aging and primatologists caring for elderly non-human primates. The PAD is now nearing the end of the development stage, but further discussion is needed to ready the database for public use. Discussion will center on the desirability of additional data available for inclusion in PAD, issues of privileged data and privacy for unpublished data, a codebook of needed information to accompany the database (collection protocols, assays, etc.), and publication rights and responsibilities for users of PAD. (Contact: Dr. Nancy Nadon, BAP, 301-496-6402)
An Aging Tissues and Organs Workshop (exploratory) will be held in the spring of 2002. The Purpose is to bring together NIA grantees to discuss aging research in a cross-cutting area and to promote collaboration on issues that cross lines of interest drawn solely on the basis of tissue type. This meeting will be designed to encourage integration of information on issues of broad interest to grantees and will include promising young investigators or investigators who are comparatively new to aging research. (Contact: Dr. Jill Carrington, BAP, 301-496-6402)
The Immunology and Aging Workshop (advisory) is being planned for the spring of 2002. The Purpose of the workshop is to present and discuss research advances in immunosenescence, gaps in our understanding of mechanisms responsible for decline in function of the immune system with age, and areas that appear promising for increased research efforts. A discussion of strategies to recruit high quality immunologists to these areas of research is also planned. The workshop is expected to promote interaction between researchers working in different areas of immunology and recommendations made by workshop participants will be included in a report of the meeting to be made available to NIA staff. (Contact: Dr.Rebecca Fuldner, BAP, 301-496-6402)
The NIA Office of Nutrition in conjunction with the NIH Office of Dietary Supplements is planning a two day advisory meeting in July 2002 in Bethesda, MD on "Dietary Supplements and the Elderly." The Purpose of the meeting is to review the current state of knowledge and to suggest future research directions for this area. An estimate from a 1999 survey revealed that 40 percent of older Americans had used some form of herbal or specialty supplement during that year. Reasons for their use included maintenance of overall health, increase of energy, improving memory, preventing or treating illness and slowing the aging process. The Number of scientific studies on safety or efficacy of these products is limited. FDA approval for their use is not required. Problems of unregulated dietary supplements include adverse events, interactions with prescription drugs, over-the-counter medications and medial conditions, contamination of preparations, mislabeling, and high cost. Of particular concern for older adults is the issue of interaction of dietary supplements and prescription medications because increasing age above 60 is associated with increased use of prescription drugs. For example, the effects of commonly taken blood-thinning medications, such as warfarin, may be modified by simultaneous ingestion of ginko biloba, garlic, ginseng, dong quai, alfalfa or St. John's Wort. The proposed workshop will bring together investigators working on dietary supplements in both human and animal studies. The agenda and speakers list is currently being developed. Other NIH Institutes and Offices, as well as other Federal agencies will be involved; currently, the National Eye Institute (NEI), the Office of Research on Women's Health (ORWH), the US Department of Agriculture (USDA), the Office of Behavioral and Social Science Research (OBSSR), NHLBI, the National Institude of diabetes and Digestive and Kidney Diseases (NIDDK), NCI, the DHHS/Office of Women's Health (OWH), and DHHS/AOA have expressed interest in participating. (Contact: Dr. Judith A. Finkelstein, NNA, 301-496-9350)
Highlights of Recent Notices and Initiatives in the NIH GuideSeveral Notices and Initiatives recently published in the NIH Guide may be of interest. NIH published updated information on the previously announced Clinical and Pediatric Loan Repayment Programs. These programs repay the educational loan debt of qualified health professionals who agree to conduct clinical or pediatric research. They allow up to $35,000 a year for each year of obligated service. The first application receipt date is February 28, 2002. NIH also announced a new web page (http://grants.nih.gov/grants/stem_cells.htm) for grant applicants and institutions interested in human embryonic stem cell research. The web page is designed to be a comprehensive source of information concerning NIH initiatives, Federal policies, and the stem cell registry. The NIH also recently modified its rule concerning notifying Institute and Center staff before submitting applications requesting more than $500,000 in direct costs in at least one year of the proposed award. Institute and Center staff now must be notified at least six weeks before the intended submission date. This change may require alteration in the timing of budget development for large applications. More information on these announcements is available in the Notices and Initiatives section of this report.
The Office of Communication and Public Liaison (OCPL) is launching a nationwide education campaign to motivate older Hispanics to keep fit. At the heart of the campaign is the new 107-page guide El Ejercicio Y Su Salud: Su guía personal para mantenerse sano y fuerte (Exercise and Your Health: A Personal Guide to Health and Fitness). A companion fotonovela - Nunca Es Tarde Para Empezar (It's Never Too Late to Start) - tells the story of Lucy, a 57-year old Latina who is trying to convince her friends that exercise is an easy, enjoyable way to improve health.
To publicize the availability of El Ejercicio Y Su Salud, the OCPL is targeting Hispanic media outlets and community groups to reach as many Hispanic seniors as possible:
Bilingual information specialists will be available at the NIA Information Center to respond to telephone inquiries and take orders for materials. For more information contact: Jane Shure, Director, Office of Communications and Public Liaison, 301-496-1752.
The following new or revised publications are now available:
Resource Directory for Older People - this updated, expanded version of the Institute's popular resource directory contains information on nearly 300 public and private organizations.
Portfolio for Progress - this new publication provides an overview of the NIA's research programs.
Pills, Patches, and Shots - this popular fact sheet has been updated and reprinted.
The following Age Pages are new or have been updated/reprinted: Hyperthermia: Too Hot for Your Health; Hypothermia: A Cold Weather Hazard; Life Extension; Forgetfulness: It's Not Always What You Think.
The following Spanish translations of Age Pages are now available: Hipotermia: El Peigro de las Bajas Temperaturas; Hipertermia-Muy Caliente Pra su Salud; El VIH, el SIDA y las Personas Mayores (HIV); Esta Considerando Hacerse una Cirugia? (surgery); La Realidad del Cancer en Hombres y Mujeres a Partir de los 50 anos (cancer); Viviendo Con la Diabetes (diabetes); El Cuidado de los pies (foot care); Medicamentos: Uselos Con Cuidado (medicines); Consejos Para Dormir Bien (sleep); Los accidentes Vasculo-cerebrales Conocidos Como Trombosis, Embolia (stroke); La mala memoria no es siempre lo que se piensa (forgetfulness).
Caregiver Guide-Tips for Caregivers of People with Alzheimer's Disease - this is a new booklet containing up-to-date information on AD caregiving from research funded at NIA's Alzheimer's Disease Centers (ADCs).
Connections, Fall 2001 - this edition of the newsletter focuses on topics of interest to professional caregivers.
For more information on any of the above publications contact: Jane Shure, Director, Office of Communications and Public Liaison, 301-496-1752.
Minority Aging and Health: NACDA Topical CD-ROM Collection - Through funding provided by the National Institute on Aging (NIA), and the Office of Research on Minority Health (ORMH) the National Archive of Computerized Data on Aging (NACDA) announces the availability of a topical CD-ROM focusing on disparities in the health and the lifecourse of minority populations. Working with NIA, ORMH, members of the NACDA Council and senior researchers in the field of gerontology, a collection of publicly available datasets was developed to promote research on disparities among minority populations in the United States. As it was felt that a full understanding of this lifecourse process required information that addressed both current and historic information on health and the aging process, datasets were selected to allow for analysis at various points in time. Over 30 datasets are contained on the Minority Aging and Health Topical CD-ROM. The topical CD-ROM stratifies the data offerings into six subheadings including studies with nationally representative samples of Black, Hispanic, and White populations for comparative analysis, as well as datasets that specifically address the health and aging process among other specific minority groups including Native Americans. In addition, there is a data series on immigrant populations. Included in the data collection are selections from longitudinal studies such as the 1998 Health Retirement Survey (HRS), American's Changing Lives Waves 1 and 2, the 1994 Hispanic Established Populations for the Epidemiologic Study of the Elderly (EPESE) and the four waves of the National Survey of Black Americans. All of these studies can be linked to additional waves and represent tremendous potential for the study of change in health and economic patterns among minority elderly across time. Collectively, the studies in this collection represent the most comprehensive and detailed information related to the health and economic stability of US minority populations currently available.
To promote the use of this data collection, the Minority Aging and Health CD-ROM will be distributed free of charge to all interested researchers. To receive a copy of the Minority Aging and Health CD-ROM users only have to fill out a request form and a copy will be sent. Request forms can also be requested either by phone at (734) 998-9790 or by sending an email to NACDA staff at NACDA@icpsr.umich.edu. Many of these datasets are also available at the NACDA Website.
Included with the CD-ROM is a series of support documents that will assist users in employing the data collection for research. All datasets in the collection come with electronic documentation and codebooks. SAS and SPSS data definitions are also included for many of the studies. Additionally, Volume 3 of the collection contains a series of publications from NIA, NIH and NACDA regarding the use of data for grants, publications, and the creation of new research. In October of 2002, NACDA will be establishing a dedicated webpage at www.icpsr.umich.edu/NACDA to further support the data collection. This webpage will provide regular updates on the availability of new data such as the 2nd wave of the Hispanic EPESE and the 3rd wave of Americans' Changing Lives. Additionally, the webpage will provide access to emerging support services, training materials, and grant opportunities for users of the data. To provide training in the use of the data, NACDA will host a five-day workshop on research in minority aging and health in the Summer of 2002, using the Minority Aging and Health CD-ROM. This course will be taught by the NACDA Resident Scientist, Kenneth Ferraro, in collaboration with other researchers in the field of minority aging. Applications for the summer workshop will be available in the Spring of 2002
An Aging World: 2001 - In December 2001, the Census Bureau released its latest report on global aging entitled An Aging World: 2001. This publication updates and expands upon earlier Census Bureau reports that focused on past, current, and projected Numbers, proportions, and growth rates of the elderly population worldwide. Recognizing that the characteristics of the elderly are increasingly heterogeneous among and within nations, a second focus of An Aging World: 2001 is to summarize socioeconomic statistics for both developed and developing nations. As with previous aging-related Bureau reports, An Aging World: 2001 will be distributed to Congress, researchers, media, universities, academic journals, libraries and other institutions in the U.S. and abroad. The initial printing run for this publication is 7,000 copies.
For more information on these publications, contact Dr. Richard Suzman, BSR, 301-3131.
From the NIH GUIDE - From Summer 2001 (Starting with the week of August 18, 2001) through Winter 2002 (Ending with the week of January 11, 2002)Published since the last National Advisory Council on Aging Meeting.Also check our NIA website “Current Funding Opportunities”(Shown here are selected Notices relevant to NIA and selected Initiatives)
Update of the PHS 398 Instructions and Forms Release Date: January 11, 2002Notice: NOT-OD-02-027This Notice is an addendum to previously published Notices in the NIH Guide for Grants and Contracts regarding PHS 398.
NIH Extramural Loan Repayment Program Regarding Clinical ResearchersRelease Date: January 8, 2002Notice: NOT-OD-02-024The Purpose of the Program is the recruitment and retention of highly qualified health professionals as clinical investigators. Through this Notice, the NIH invites qualified health professionals who contractually agree to engage in clinical research as extramural grantees or awardees for at least two years, to apply for participation in the NIH Loan Repayment Program for Clinical Researchers.
Extramural Loan Repayment Program for Pediatric Researchers Release Date: January 8, 2002Notice: NOT-OD-02-025The Purpose of the Program is the recruitment and retention of highly qualified health professionals as pediatric researchers. Through this Notice, the NIH invites qualified health professionals who contractually agree to engage in pediatric research as extramural grantees or awardees for at least two years, to apply for participation in the NIH Pediatric Research Loan Repayment Program.
Graduate Student Compensation Release Date: December 10, 2001Notice: NOT-OD-02-017This Notice establishes a new policy related to the level of compensation for graduate students supported by funds from National Institutes of Health (NIH) research grants and cooperative agreements. This Notice supersedes the Notice that appeared in the NIH guide for Grants and Contracts on December 2, 1998 (http://grants.nih.gov/grants/guide/Notice-files/not98-168.html). Under this new policy, the maximum amount awarded by the NIH for the support of a graduate student supported on a research grant or a cooperative agreement is tied to the zero level National Research Service Award (NRSA) stipend in effect at the time the grant award is issued. The schedule for NRSA stipends can be found at http://grants.nih.gov/training/nrsa.htm.
Joint NSF/NIH Initiative to Support Collaborative Research in Computational Neuroscience (CRCNS) NSF 02-018Release Date: December 6, 2001Notice: NOT-MH-01-014This Notice announces a joint initiative between the National Science Foundation (NSF) and seven participating National Institute of Health (NIH) Institutes (released by NSF as NSF 02-018, http://www.nsf.gov/cgi-bin/getpub?nsf02018) to support interdisciplinary research in computational neuroscience. Both agencies recognize the need for research that focuses on integrating computational models and methods with neuroscience. This solicitation is designed to encourage new and existing collaborations at this interface. Appropriate scientific areas of investigations are those that are currently supported by NSF and NIH, or related to the missions of the two agencies.
Implementation Issues for Human Embryonic Stem Cell Research – Frequently Asked Questions Release Date: November 16, 2001Notice: NOT-OD-02-014In response to inquiries about the recent NIH guide Notices pertaining to policies on human embryonic stem cell research, NIH will be posting periodically additional information to assist investigators and research administrators.
Federal Government Clearances for Receipt of International Shipment of Human Embryonic Stem Cells Release Date: November 16, 2001Notice: NOT-OD-02-013Many of the sources of human embryonic stem cells are located in countries other than the United States. For investigators wishing to conduct federal research using human embryonic stem cells, permission may be required for their importation. Several U.S. federal government agencies have policies in place for the importation of biological specimens.
Mail Addressed to The National Institutes of Health Release Date: November 13, 2001Notice: NOT-OD-02-012All United States Postal Service (USPS) mail addressed to the National Institutes of Health must use the unique NIH Zip Code 20892. All USPS mail addressed to the National Library of Medicine should bear the unique NLM Zip Code of 20894. All mail using 20892 and 20894 Zip Codes will be cleared through the NIH North Stonestreet Mail Facility. This will ensure that special procedures and precautions will be used to screen the mail before it is delivered to the various NIH offices on and off campus. This is an important measure to provide for the safety of all individuals who must handle mail.
Notice of Criteria for Federal Funding of Research on Existing Human Embryonic Stem Cells and Establishment of NIH Human Embryonic Stem Cell RegistryRelease Date: November 7, 2001Notice: NOT-OD-02-005On August 9, 2001, at 9:00 p.m. EDT, the President announced his decision to allow Federal funds to be used for research on existing human embryonic stem cell lines as long as prior to his announcement (1) the derivation process (which commences with the removal of the inner cell mass from the blastocyst) had already been initiated and (2) the embryo from which the stem cell line was derived no longer had the possibility of development as a human being. In order to facilitate research using human embryonic stem cells, the NIH is creating a Human Embryonic Stem Cell Registry that will list the human embryonic stem cells that meet the eligibility criteria.
Notice of Extended Receipt Date and Supplemental Information Guidance for Applications Requesting Funding That Proposes Research With Human Embryonic Stem Cells Release Date: November 7, 2001Notice: NOT-OD-02-006The NIH is preparing to accept requests for funding of research using human embryonic stem cells. Federal funding is available only for research using those lines included on the NIH Human Embryonic Stem Cell Registry http://escr.nih.gov (hereafter referred to as the "Registry") which confirms that the stem cell lines are in compliance with the President's criteria as stated on August 9, 2001 http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-02-005.html. Principal investigators and their applicant institutions are urged to read this guidance carefully and follow the steps outlined for the specific types of funding requests that follow.
Notice of Withdrawal of NIH Guidelines for Research Using Pluripotent Stem Cells(Published August, 25, 2000, 65 FR 51976, Corrected November 21, 2000, 65 FR 69951)Release Date: November 7, 2001Notice: NOT-OD-02-007The President has determined the criteria that allow Federal funding for research using existing embryonic stem cell lines http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-02-005.html. Thus, the NIH GUIDELINES as they relate to human pluripotent stem cells derived from human embryos are no longer needed. Inquiries may be directed to: the Deputy Director for Extramural Research, NIH, DDER@nih.gov.
Revised Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs Release Date: October 16, 2001Notice: NOT-OD-02-004The National Institutes of Health (NIH) is updating its policy on the acceptance of applications requesting direct costs of $500,000 or more for any one year. Effective with the January 1, 2002 receipt dates, applicants must seek agreement to accept assignment from Institute/Center staff at least 6 weeks prior to the anticipated submission of any application requesting $500,000 or more in direct costs for any year.
Additional Information About the Revised PHS 398 and PHS 2590 Forms Release Date: October 10, 2001 (See Addendum NOT-OD-02-027)Notice: NOT-OD-02-002This Notice is an addendum to NOT-OD-01-049, entitled "REVISED PHS 398 AND PHS 2590 NOW AVAILABLE", which was previously published on July 10, 2001 in the NIH Guide for Grants and Contracts (http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-01-049.html). In response to comments and suggestions from the research community on how NIH can enhance the application forms to make them more user-friendly, NIH is offering the PHS 398 and PHS 2590 forms as Rich Text Format files as well as Portable Document Format files.
Amendment: NIH Policy and Guidelines on the Inclusion of Women and Minorities As Subjects in Clinical Research - October, 2001 Release Date: October 9, 2001Notice: NOT-OD-02-001The National Institutes of Health policy on the Inclusion of Women and Minorities as Subjects in Clinical Research has been amended. A complete copy of the amended policy may be found on the "Inclusion of Women and Minorities Policy Implementation" web site: http://grants.nih.gov/grants/funding/women_min/women_min.htm. EFFECTIVE DATE: This amended policy is effective immediately and applies to all grants and cooperative agreements currently active and to be awarded. Contract solicitations issued as of October 2001 must adhere to the amended policy.
Availability to the Scientific Community of Mice With Selective Mutations Release Date: October 5, 2001Notice: NOT-MH-01-011Request For Applications (RFA) MH-99-007, "Mouse Mutagenesis and Phenotyping: Nervous System and Behavior," available at http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-99-007.html, was issued in 1999. It is expected that the mouse resources generated by these programs will be made available to the research community by a designated Mouse Neuroscience Phenotyping and Distribution Center, one of whose functions will be the distribution of the mice. However, it is anticipated that some mutant mice or cryopreserved germplasm from mutant mice may be available sooner for distribution directly by the three mutagenesis facilities. Information at these sites will be continually updated as the resources become available.
Availability of Mutant Mice to the Scientific CommunityNorthwestern University Neurogenomics Project (available in six months) (http://genome.northwestern.edu/)Tennessee Mouse Genome Consortium (available now) (http://tnmouse.org/index.html)Neuroscience Mutagenesis Facility (available now) (http://www.jax.org/nmf/).
Human Embryonic Stem Cell Research Resource Infrastructure Enhancement Award - PA Number : PAR-02-023 Application Receipt Dates: January 8, 2002, March 8, 2002, May 8, 2002, July 8, 2002, and September 6, 2002http://grants.nih.gov/grants/guide/pa-files/PAR-02-023.html
MTOPS Prostate Samples Analysis Consortium (MPSA) - RFA: RFA-DK-02-017Application Receipt Date: March 20, 2002; http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-02-017.html
Resource Centers and Coordinating Center for Minority Aging Research - RFA-AG-02-004Application Receipt Date: March 12, 2002 http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-02-004.html
Exploratory/Developmental Grants in Social Neuroscience - RFA-MH-02-004Application Receipt Date: January 11, 2002; http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-004.html
Informal Caregiving Research for Chronic Conditions - RFA-NR-02-001 Application Receipt Date: February 26, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-NR-02-001.html
International Collaborative Genetics Research Training Program - RFA-TW-02-001 Application Receipt Date: March 25, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-TW-02-001.html
The Placebo Effect in Clinical Practice - RFA-AT-02-001Application Receipt Date: April 11, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-02-001.html
Research on Adult and Family Literacy - RFA-HD-02-004 Application Receipt Date: May 15, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-02-004.html
Studies of the Ethical, Legal, and Social Implications (ELSI) of Human Genetic Variation Research for Individuals and Diverse Racial and Ethnic Groups - RFA-HG-02-003Application Receipt Date: July 10, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-02-003.html
Social and Cultural Dimensions of Health - PA-02-043Application Receipt Date: Standard Receipt Dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-043.html
Aging, Race, and Ethnicity in Prostate Cancer - RFA: RFA-AG-02-003 Application Receipt Date: December 12, 2001http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-02-003.html
Bioengineering Research Partnerships - PA Number: PAR-02-010Application Receipt Dates: January 24, 2002 and August 12, 2002http://grants.nih.gov/grants/guide/pa-files/PAR-02-010.html
Building Interdisciplinary Research Careers in Women's Health - RFA-OD-02-001 Application Receipt Date: March 14, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-02-001.html
Bioengineering Research Grants - PA Number: PA-02-011Application Receipt Dates: Standard Receipt Dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-011.html
Development of Pet And Spect Ligands for Brain Imaging (Phased Innovation Award) - RFA-MH-02-003Application Receipt Date: December 11, 2001http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-003.html
Elucidation of the Underlying Mechanisms of Placebo Effect - RFA: RFA-AT-02-002Application Receipt Date: April 11, 2002http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-02-002.html
Jointly Sponsored NIH Predoctoral Training Program in The Neurosciences - PA Number: PAR-02-017Application Receipt Date: May 10http://grants.nih.gov/grants/guide/pa-files/PAR-02-017.html
Development of Pet and Spect Ligands for Brain Imaging (SBIR Award) - PA Number: PA-02-028Application Receipt Dates: Standard receipt dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-028.html
Neurotechnology Research, Development, and Enhancement - PA Number: PA-02-003Application Receipt Dates: Standard Receipt Dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-003.html
Plasticity of Human Stem Cells in The Nervous System - PA Number: PA-02-025Application Receipt Dates: Standard Receipt Dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-025.html
Probes for Microimaging the Nervous System (SBIR Award) - PA Number: PA-02-029Application Receipt Dates: Standard receipt dateshttp://grants.nih.gov/grants/guide/pa-files/PA-02-029.html
MTOPS Prostate Samples Analysis Consortium (MPSA)http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-02-017.htmlRelease Date: November 21, 2001RFA: RFA-DK-02-017
Announced with the National Institute of Diabetes and Digestive and Kidney.
Letter of Intent Receipt Date: February 20, 2002Application Receipt Date: March 20, 2002
PurposeThe National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute on Aging (NIA) invite cooperative agreement applications to establish a MTOPS Prostate Samples Analysis Consortium (MPSA) that will participate in the discovery and validation of biologic markers or genetic susceptibility tests for the detection, risk assessment, and assessment of disease progression of benign prostatic hyperplasia (BPH). The Purpose of the MTOPS Prostate Samples Analysis (MPSA) Consortium is to establish a scientific consortium of investigators with resources for basic and translational research on biomarkers for BPH. The existing MTOPS Data Coordinating Center will be an integral member of this new MPSA Consortium.
Direct inquiries regarding programmatic issues to:Frank Bellino, Ph.D.Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: fb12a@nih.gov
Human Embryonic Stem Cell Research Resource Infrastructure Enhancement Award http://grants.nih.gov/grants/guide/pa-files/PAR-02-023.htmlRelease Date: November 29, 2001PA Number: PAR-02-023
Announced with the National Center for Research Resources, National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of Mental Health.
Application receipt dates: January 8, 2002, March 8, 2002, May 8, 2002, July 8, 2002, and September 6, 2002.PurposeThe Purpose of this initiative is to increase the research resource capacity for basic research using human embryonic stem cells (hESC). The research projects proposed under this Program Announcement (PA) will address the expansion, testing, quality assurance, and distribution of existing cell lines that are in compliance with criteria for federal funding of research on existing hESC as described in http://grants.nih.gov/grants/guide/Notice-files/NOT-OD-02-005.html.
Direct inquiries regarding programmatic issues to:Jill Carrington, Ph.D.Biology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: jc189n@NIH.GOV
Behavioral & Social Research Program (BSR) Exploratory/Developmental Grants in Social Neuroscience http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-004.htmlRelease Date: September 6, 2001RFA: RFA-MH-02-004
Announced with the National Institute of Mental Health (http://www.nimh.nih.gov), and the National Institute of Child Health and Human Development (http://www.nichd.nih.gov)
Letter of Intent Receipt Date: December 11, 2001Application Receipt Date: January 11, 2002
PurposeThis initiative seeks applications that will examine the neural processes involved in social behavior within the framework of the exploratory/developmental granting mechanism. The intent of this RFA is to act as a catalyst for a newly emerging area of interdisciplinary research merging social/personality/affective psychology with neuroscience in order to elucidate fundamental mechanisms of social behavior.
Direct inquiries regarding programmatic issues to:Daniel B. Berch, Ph.D.Chief, Section on Cognitive AgingIndividual Behavioral Processes BranchBehavioral and Social Research ProgramNational Institute on Aging, NIH7201 Wisconsin Avenue, Suite 533Bethesda, MD 20892-9205Telephone: (301) 594-5942FAX: (301) 402-0051Email: Berchd@nia.nih.gov
Announced with the National Center for Complementary and Alternative Medicine (http://nccam.nih.gov), John E. Fogarty International Center (http://www.fic.nih.gov/), National Heart, Lung, and Blood Institute (http://www.nhlbi.nih.gov), National Institute on Alcohol Abuse and Alcoholism (http://www.niaaa.nih.gov), National Institute of Allergy and Infectious Diseases (http://www.niaid.nih.gov), National Institute of Arthritis and Musculoskeletal and Skin Diseases (http://www.niams.nih.gov), National Institute of Dental and Craniofacial Research (http://www.nidr.nih.gov), National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov), and the National Institute of Mental Health (http://www.nimh.nih.gov).
Letter of Intent Receipt Date: March 1, 2002Application Receipt Date: April 11, 2002
PurposeThe proposed initiative is expected to stimulate investigator-initiated research investigations on how placebos and placebo effects impact on clinical practice. An important goal is to understand what factors are necessary to elicit a placebo effect in clinical practice so that the benefits of the therapeutic intervention can be enhanced to improve health and promote wellness.
Direct inquiries regarding programmatic issues to:Daniel B. Berch, Ph.D.Chief, Section on Cognitive AgingIndividual Behavioral Processes BranchBehavioral and Social Research ProgramNational Institute on Aging, NIH7201 Wisconsin Avenue, Suite 533Bethesda, MD 20892-9205Telephone: (301) 594-5942Fax: (301) 402-0051E-mail: Berchd@nia.nih.gov
Announced with the National Institute of Child Health and Human Development (http://www.nichd.nih.gov/), and the National Institute for Literacy (http://www.nifl.gov/)
Letter of Intent Receipt Date: April 15, 2002Application Receipt Date: May 15, 2002
PurposeThis initiative invites research grant applications to develop new knowledge on adult literacy learning and new knowledge relevant to the critical factors that influence the instruction and development of literacy (reading and writing) competencies in adults and in young children (birth through kindergarten entrance) through adult and family literacy program activities, to identify or design the most effective program structures and models of service delivery.
Daniel B. Berch, Ph.D.Chief, Section on Cognitive AgingIndividual Behavioral Processes BranchBehavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 533Bethesda, MD 20892-9205Telephone: (301) 594-5942FAX: (301) 402-0051Email: Berchd@nia.nih.gov
Announced with the National Institute of Nursing Research (http://www.nih.gov/ninr).
Letter of Intent Receipt Date: January 31, 2002Application Receipt Date: February 26, 2002
PurposeThis initiative invites applications for research grants to advance the science in informal caregiving in the home for care recipients with chronic illness, disability, or functional impairment requiring partial or full dependency on others. This RFA targets studies of informal caregiving interventions to improve caregiver health and quality of life, caregiving processes, and caregiving effectiveness and health outcomes.
Direct inquiries regarding programmatic issues to:Sidney M. Stahl, PhDChief, Behavioral MedicineNational Institute on Aging7201 Wisconsin Ave., #533Bethesda, MD 20892-9205Telephone: (301) 402-4156FAX: (301) 402-0051Email: Sidney_Stahl@nih.gov
Announced with the National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, National Institute of Nursing Research, and the Fogarty International Center.Letter of Intent Receipt Date: March 1, 2002Application Receipt Date: July 10, 2002
Purpose Human genetic variation research, especially as it relates to risk factors for common, complex disorders, is leading to increased knowledge regarding variation among individuals and how this variation may contribute to the health status of individuals. It is also leading to more knowledge about variation within and among different racial and ethnic groups (to the extent that such groups can reasonably be identified) and how this variation may contribute to the aggregate health status of those groups. The NHGRI's new initiative to develop a haplotype map of the human genome will make it possible to conduct this type of research (in particular, disease gene association studies) more quickly and efficiently than ever before, resulting in an even more rapid proliferation of this new information. Direct inquiries regarding programmatic issues to:Jennifer Harris, Ph.D.Behavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 533, MSC 9205Bethesda, MD 20892-9205TEL: (301) 496-3138FAX: (301) 402-0051Email: jh475o@nih.gov
Announced with the Fogarty International Center (http://www.fic.nih.gov/), National Institute of Mental Health (http://www.nimh.nih.gov/), National Institute of Environmental Health Sciences (http://www.niehs.nih.gov/), National Institute on Alcohol Abuse and Alcoholism (http://www.niaaa.nih.gov/), National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/), National Human Genome Research Institute (http://www.nhgri.nih.gov/), and the National Institute on Drug Abuse (http://www.nida.nih.gov/).
Letter of Intent Receipt Date: January 25, 2002Application Receipt Date: March 25, 2002
PurposeThis initiative invites applications from nonprofit, private or public, domestic or international educational and research institutions in developed countries to establish research-training programs that contribute to the capacity of developing country investigators and institutions to conduct human genetics research relevant to the health needs of the country. Applications are solicited to create innovative research training programs within existing scientific collaborations between developed and developing country researchers to begin to build a critical mass of scientists, health professionals and academics with human genetics expertise and a sustainable research environment at the collaborating developing country institution.
Direct inquiries regarding programmatic issues to:Jennifer Harris, Ph.D.Behavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Ave., Suite 533Bethesda, MD 20892-9205Telephone: (301) 496-3138Fax: (301) 402-0051Email: harrisje@mail.nih.gov
Resource Centers and Coordinating Center for Minority Aging Research http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-02-004.html (NOTE: New receipt date is March 12, 2002 - Announced in Notice AG-02-001)Release Date: December 17, 2001RFA: RFA-AG-02-004
Announced with the National Institute of Nursing Research (http://www.nih.gov/ninr) and the National Center for Minority Health and Health Disparities (NCMHD) (http://ncmhd.nih.gov/).
Letter of Intent Receipt Date: January 30, 2002Application Receipt Date: March 12, 2002
Purpose This initiative invites applications from qualified institutions for the creation or continuation of Resource Centers for Minority Aging Research (RCMARs). RCMARs focus research upon specific social, cultural, and behavioral mechanisms leading to improved health and functioning by emphasizing research designed to: (1) inform public policy; (2) develop culturally-informed disease and disability prevention and health promotion strategies; (3) improve community, group, or individual based interventions that will result in optimal health outcomes; and (4) improve the measurement of social, psychological, economic, and other concepts germane to the health of older minority populations.
Direct inquiries regarding programmatic issues to: Sidney M. Stahl, Ph.D.Behavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 533Bethesda, MD 20892-9205Telephone: (301) 402-4156FAX: (301) 402-0051Email: ss333h@NIH.GOV
Social and Cultural Dimensions of Health http://grants.nih.gov/grants/guide/pa-files/PA-02-043.htmlRelease Date: December 21, 2001PA Number: PA-02-043
Announced with the Office of Behavioral and Social Sciences Research, National Cancer Institute, National Center for Complementary and Alternative Medicine, National Eye Institute, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Mental Health, National Institute of Nursing Research, National Institute on Alcohol Abuse and Alcoholism, National Institute on Arthritis, Musculoskeletal, and Skin Diseases, National Institute on Drug Abuse.
Application Receipt Date: Standard Receipt Dates
PurposeThis initiative invites qualified researchers to submit research grant applications on the social and cultural dimensions of health. The goal of this announcement is to (a) elucidate basic social and cultural constructs and processes used in health research, (b) clarify social and cultural factors in the etiology and consequences of health and illness, (c) link basic research to practice for improving prevention, treatment, health services, and dissemination, and (d) explore ethical issues in social and cultural research. The goal of this program announcement is to encourage further development of health-related social sciences research relevant to the missions of the NIH Institutes and Centers (ICs).
Direct inquiries regarding programmatic issues to: Sidney Stahl, Ph.D.Behavioral and Social Research ProgramNational Institute on AgingGateway Building, Room 525 MSC 92057201 Wisconsin AvenueBethesda, MD 20892-9205Telephone: 301-402-4156Fax: 301-402-0051E-mail: stahls@mail.nih.gov
Geriatrics Program (GP) Aging, Race, and Ethnicity in Prostate Cancer http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-02-003.htmlRelease Date: August 29, 2001RFA: RFA-AG-02-003
Letter of Intent Receipt Date: November 13, 2001Application Receipt Date: December 12, 2001
PurposeThe Purpose of this RFA is to support research that will provide information leading to better prevention, diagnosis, prognosis, and treatment of prostate cancer in the age range in which prostate cancer most frequently occurs in the diverse population groups at risk (i.e., in men 65 years and older). Proposals to address the issues indicated above may be focused on genetic and environmental risk factors, pre-malignant changes, tumorigenesis, detection of localized and advanced disease, prognostic indicators, disease progression, and response to treatment.
Direct inquiries regarding programmatic issues to:Rosemary Yancik, Ph.D.Geriatrics ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3E 327 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-5278FAX: (301) 402-1784Email: ry3e@NIH.GOV
Bioengineering Research Grants http://grants.nih.gov/grants/guide/pa-files/PA-02-011.htmlRelease Date: October 11, 2001PA Number: PA-02-011
Announced with the National Cancer Institute, National Center for Research Resources, National Eye Institute, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Biomedical Imaging and Bioengineering, National Institute of Child Health and Human Development, National Institute on Drug Abuse, National Institute on Deafness and Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, and the National Library of Medicine.
Application Receipt Dates: Standard Receipt Dates
PurposeParticipating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Grants (BRGs) for basic and applied multi-disciplinary research that addresses important biological or medical research problems. The BRGs support multi-disciplinary research performed in a single laboratory or by a small Number of investigators that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. A BRG application may propose hypothesis-driven, discovery-driven, developmental, or design-directed research at universities, national laboratories, medical schools, large or small businesses, or other public and private entities.
Direct inquiries regarding programmatic issues to:Winifred K. Rossi, M.A.Geriatrics ProgramNational Institute on AgingGateway Building - Suite 3E327, MSC 9205Bethesda, MD 20892-9205TEL: 301-496-3836FAX: 301-402-1784Email: wr33a@nih.gov
Bioengineering Research Partnerships http://grants.nih.gov/grants/guide/pa-files/PAR-02-010.htmlRelease Date: October 11, 2001PA Number: PAR-02-010
Announced with the National Cancer Institute, National Eye Institute, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Biomedical Imaging and Bioengineering, National Institute of Child Health and Human Development, National Institute on Drug Abuse, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of General Medical Sciences, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, and the National Library of Medicine.
Notice of Intent Receipt Dates: December 21, 2001 and July 12, 2002Application Receipt Dates: January 24, 2002 and August 12, 2002
PurposeParticipating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic and applied multi-disciplinary research that addresses important biological or medical research problems. A BRP is a multi-disciplinary research team applying an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. The partnership must include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical investigators. A BRP may propose hypothesis-driven, discovery-driven, developmental, or design-directed research at universities, national laboratories, medical schools, large or small businesses, or other public and private entities or combinations of these entities.
Announced with the Office of Research on Women's Health (http://www4.od.nih.gov/orwh/), National Institute on Alcohol Abuse and Alcoholism (http://www.niaaa.nih.gov/), National Institute of Arthritis and Musculoskeletal and Skin Diseases (http://www.niams.nih.gov/), National Institute of Child Health and Human Development (http://www.nichd.nih.gov/), National Institute of Dental and Craniofacial Research(http://www.nidr.nih.gov/), National Institute of Diabetes and Digestive and Kidney Diseases(http://www.niddk.nih.gov/), National Institute of Mental Health (http://www.nimh.nih.gov/), Office of Dietary Supplements (http://dietary-supplements.info.nih.gov/), and the Agency for Healthcare Research and Quality (http://www.ahrq.gov/).
Letter of Intent Receipt Date: February 14, 2002Application Receipt Date: March 14, 2002
PurposeThis initiative invites institutional career development award applications for Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Career Development Programs, hereafter termed "Programs." Programs will support research career development of junior faculty members, to be known as Interdisciplinary Women's Health Research (IWHR) Scholars, who have recently completed clinical training or postdoctoral fellowships, and who are commencing basic, translational, clinical and/or health services research relevant to women's health.
Direct inquiries regarding programmatic issues to:Sheryl Sherman, Ph.D.Geriatrics ProgramNational Institute on AgingGateway Building - Suite 3E327, MSC 9205Bethesda, MD 20892-9205TEL: 301-496-3836FAX: 301-402-1784Email: wr33a@nih.gov
Announced with the National Institute of Mental Health (http://www.nimh.nih.gov/), National Institute on Deafness and Other Communication Disorders (http://www.nidcd.nih.gov/), National Institute of Child Health and Human Development (http://www.nichd.nih.gov/), National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/), and the National Institute on Drug Abuse (http://www.nida.nih.gov/).
PurposeThe Purpose of this Program Announcement (PA) is to encourage submission of new research project grant (R01) and exploratory/developmental research grant (R21) applications to research and develop innovative technologies, methodologies, or instrumentation for basic or clinical studies of the brain in human or non-human animals. Also solicited are applications for support to research, development, and significant enhancements to existing technologies important to understanding the brain.
Direct inquiries regarding programmatic issues to:Bradley C. Wise, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3C307, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Development of Pet and Spect Ligands for Brain Imaging (Phased Innovation Award) http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-003.htmlRelease Date: September 27, 2001RFA: RFA-MH-02-003
Announced with the National Institute of Mental Health (http://www.nimh.nih.gov/) and the National Institute on Drug Abuse (http://www.nida.nih.gov/).
Letter of Intent Receipt Date: November 12, 2001Application Receipt Date: December 11, 2001
PurposeThe intent of this solicitation is to invite applications for the development of novel radioligands for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging in human brain, and that incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies. This initiative is intended to facilitate the development of: 1) PET and SPECT probes for molecular targets (e.g., receptors, intracellular messengers, disease-related proteins) that are of broad interest to the neuroscience research community, and 2) new technologies for radiotracer development. Small businesses are encouraged to respond to the parallel PA, PA-02-028, Development of PET and SPECT Ligands for Brain Imaging (SBIR Award). The same expedited review and transition from Phase I to Phase II funding are expected to apply, as will the same cost and time limitations as this RFA for Phased Innovation Awards.
Direct inquiries regarding programmatic issues to:Molly Wagster, Ph.D. and Neil Buckholtz, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on AgingGateway Building, Suite 3C3077201 Wisconsin AvenueBethesda, MD 20892Telephone: (301) 496-9350FAX: (301) 496-1494Email: wagsterm@nia.nih.gov; buckholn@nia.nih.gov
Announced with the Trans-NIH T32 Jointly Sponsored Training Committee: National Institute on Aging (NIA) (http://www.nih.gov/nia/), National Institute of Child Health and Human Development (NICHD) (http://www.nichd.nih.gov/), National Institute on Deafness and Other Communication Disorders (NIDCD) (http://www.nidcd.nih.gov/), National Institute of Dental and Craniofacial Research (NIDCR) (http://www.nidr.nih.gov/), National Institute on Drug Abuse (NIDA) (http://www.nida.nih.gov/), National Eye Institute (NEI) (http://www.nei.nih.gov/), National Institute of General Medical Sciences (NIGMS) (http://www.nigms.nih.gov/), National Institute of Mental Health (NIMH) (http://www.nimh.nih.gov/), National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov/), and the National Institute of Nursing Research (NINR) (http://www.nih.gov/ninr/).
Letter of Intent Receipt Date: April 5Application Receipt Date: May 10
PurposeThe aim of the program is to encourage and support broad, early-stage (pre-thesis) training in the neurosciences by offering institutions a single comprehensive training grant. It is expected that these training programs will contribute to basic and disease-related neuroscience research that is relevant to the participating NIH Institutes.
Direct inquiries regarding programmatic issues to:Bradley C. Wise, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Room 3C307, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Elucidation of the Underlying Mechanisms of Placebo Effect http://grants.nih.gov/grants/guide/rfa-files/RFA-AT-02-002.htmlRelease Date: November 8, 2001RFA: RFA-AT-02-002
Announced with the National Center for Complementary and Alternative Medicine (http://nccam.nih.gov), John E. Fogarty International Center (http://www.fic.nih.gov), National Heart, Lung, and Blood Institute (http://www.nhlbi.nih.gov), National Institute on Alcohol Abuse and Alcoholism (http://www.niaaa.nih.gov), National Institute of Allergy and Infectious Diseases (http://www.niaid.nih.gov), National Institute of Arthritis and Musculoskeletal and Skin Diseases (http://www.niams.nih.gov), National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov), National Institute on Drug Abuse (http://www.nida.nih.gov), National Institute of General Medical Sciences (http://www.nigms.nih.gov), National Institute of Mental Health (http://www.nimh.nih.gov), and the National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov).
PurposeThe goal of this initiative is to stimulate crossing cutting, integrative research aimed at delineating the underlying mechanisms by which a placebo leads to its ultimate physiological and psychological effects. In the context of this initiative, integrative research is defined as the combined use of approaches from several different scientific disciplines such as sociology, psychology, cell biology, physiology, genetics, and/or molecular biology to probe neurological, endocrinological, immunological and other relevant systems in order to define the mechanisms underlying placebo effects.
Announced with the National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov), National Institute of Mental Health (http://www.nimh.nih.gov), and the National Heart, Lung, and Blood Institute (http://www.nhlbi.nih.gov).
PurposeThis initiative invites applications for studies on the plasticity and behavior of human stem cells, and regulation of their replication, differentiation and function in the nervous system. Because of their ability to generate neurons and glia, stem cells are promising candidates for the development of cellular and genetic therapies for neurological disorders, including congenital, neurodevelopmental, neuropsychiatric and neurodegenerative diseases, as well as neuroregulatory problems in heart, lung, and blood diseases, and sleep disorders. This Program Announcement (PA) invites applications for support of research that characterizes cellular, molecular and genetic mechanisms that allow human stem and precursor cells to express plasticity and lineage choices. Projects that address comparisons between different classes of human stem cells, and between human and non-human stem cells would also be directly relevant to this PA.
Development of Pet and Spect Ligands for Brain Imaging (SBIR Award) http://grants.nih.gov/grants/guide/pa-files/PA-02-028.htmlRelease Date: December 4, 2001PA Number: PA-02-028
Announced with the National Institute of Mental Health (http://www.nimh.nih.gov/), National Institute of Deafness and Other Communication Disorders (http://www.nidcd.nih.gov/), National Institute of Alcohol Abuse and Alcoholism (http://www.niaaa.nih.gov/), National Institute on Drug Abuse (http://www.nida.nih.gov/), National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/), National Institute of Environmental Health Sciences (http://www.niehs.nih.gov/).
Application Receipt Dates: Standard receipt dates
PurposeThe intent of this Program Announcement (PA) is to invite applications for the commercial development of novel radioligands for PET and SPECT imaging in human brain, and to incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies. This PA inviting SBIR applications is a parallel solicitation to RFA-MH-02-003, (Development Of PET and SPECT Ligands for Brain Imaging (Phased Innovation Award), which is a request for R21 and R33 applications with a single application receipt date (see http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-003.html).
Direct inquiries regarding programmatic issues to:Neil S. Buckholtz, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 3C307Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: buckholn@nia.nih.gov
Probes for Microimaging the Nervous System (SBIR Award) http://grants.nih.gov/grants/guide/pa-files/PA-02-029.htmlRelease Date: December 5, 2001PA Number: PA-02-029
Announced with the National Institute of Mental Health (http://www.nimh.nih.gov/), National Institute on Deafness and Other Communication Disorders (http://www.nidcd.nih.gov/), National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/), and the National Institute of Biomedical Imaging and Bioengineering (http://www.nibib.nih.gov/).
PurposeThis initiative invites grant applications for Small Business Innovation Research (SBIR) projects on research and development of probes useful in imaging the structure and function of the brain and other parts of the nervous system, with award duration and amounts greater than those routinely allowed under the SBIR program. Encouraged are applications from teams of investigators from commercial, academic and other sectors of the research community. Non-commercial partners, including those at colleges and universities, may play important roles in SBIR-supported research, and may receive substantial support for their efforts. This PA must be read in conjunction with the Omnibus Solicitation of the NIH, CDC and FDA SBIR and STTR Grant Applications found at http://grants.nih.gov/grants/funding/sbir.htm, the instructions for Phase II Grant Applications found at http://grants.nih.gov/grants/funding/sbir2/index.htm and the PHS 398 Instructions (http://grants.nih.gov/grants/funding/phs398/phs398.html). Except as noted below, all instructions and information in these documents also apply to applications submitted in response to this PA.
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