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In November 2006, NICEATM published recommendations on the use of four in vitro methods for identifying
ocular corrosives and severe irritants:
- The bovine corneal opacity and permeability test method
- The isolated chicken eye test method
- The isolated rabbit eye test method
- The hen's egg test - chorioallantoic membrane test method
One of the ICCVAM recommendations was to consider the validation status of these four in vitro
ocular test methods for identifying mild and moderate ocular irritants and nonirritants. NICEATM and
ICCVAM have prepared draft BRDs assessing the current validation status of the four test methods
for their ability to identify moderate and mild irritants and nonirritants. These documents
will be reviewed in May 2009 by an independent international peer review panel.
Federal Register Notice
(Vol. 74, No. 60, page 14556-14557, March 31, 2009):
Announcement of an Independent Scientific Peer Review Panel on Alternative Ocular Safety
Testing Methods; Availability of Draft Background Review Documents (BRD); Request for Comments
View Federal Register notice [PDF]
Submit comment in response to the Federal Register notice
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