NIGMS Invites Biologists to Join High-Throughput Structure Initiative |
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February 12, 2009 • National Institute of General Medical SciencesNIGMS announces plans for PSI:Biology, a program to support research partnerships between groups of biologists and high-throughput structure determination centers to solve problems of biomedical importance. |
Structure of Important Neurological Receptor |
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October 6, 2008 • Scripps Research InstituteNIGMS-funded biologists have solved the structure of an adenosine receptor that could lead to drugs for neurological disorders. |
Protein Structure Initiative Discovery Points to Drugs for Flu |
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August 25, 2008 • Rutgers UniversityAn NIGMS-funded collaboration has revealed a key binding pocket for flu infection. Disrupting the interaction could treat flu. |
New Web Portal to Advance Wide Range of Protein Studies |
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April 3, 2008 • National Institute of General Medical SciencesThe Protein Structure Initiative has launched an online resource that will enable scientists from across biomedical disciplines to easily access a wealth of information about proteins. |
Scientists Unveil Structure of Molecular Target of Many Drugs |
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October 29, 2007 • National Institute of General Medical SciencesScientists supported by two major NIH initiatives have captured the first structure of a human G protein-coupled receptor, one of a family of membrane proteins targeted by about half of today's pharmaceuticals. |
Protein Structure Initiative Launches New Resources for the Scientific Community |
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November 6, 2006 • National Institute of General Medical SciencesNow that the Protein Structure Initiative (PSI) has established efficient pipelines for determining the three-dimensional shapes of proteins, it is creating new mechanisms for sharing the resources it has developed with the scientific community. |
NIGMS Announces PSI Molecular Modeling Centers |
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August 10, 2006 • National Institute of General Medical SciencesTwo newly funded molecular modeling centers will develop computational methods for reliably predicting protein structures. |
NIGMS Funds New Center for Molecular Modeling |
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July 20, 2006 • Burnham InstituteA new NIGMS-funded center will improve predictions of three-dimensional protein structures from raw genetic sequence. The center will unite scientists from the Burnham Institute in La Jolla and the University of California, San Diego. |
Scientists Take Snapshots of Enzyme Action |
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June 12, 2006 • Brookhaven National LaboratoryNIGMS-funded researchers have learned the structure and mechanism of an enzyme that eliminates drugs and toxic compounds from the body. Understanding these details could help reveal why such compounds are not always properly eliminated. |
Discovery Could Help Fight Cystic Fibrosis Infection |
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June 9, 2006 • Argonne National LaboratoryNIGMS-supported scientists have solved the structure of a key protein involved in the infections that strike people with cystic fibrosis. The finding provides a possible drug target for fighting these infections. |
Mini-Synchrotron Could Increase Access to Key Research Tool |
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March 2, 2006 • National Institute of General Medical SciencesScientists based in Palo Alto, California, have produced brilliant X-ray light from a device just a fraction of the standard size. The advance could transform numerous fields of biomedical research by vastly improving access to a key resource for studying the properties of molecules. |
Biochemists Detect Proteins' Subtle 'Backrub' Motion |
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February 7, 2006 • Duke UniversityBiochemists have uncovered a new type of protein movement and dubbed it the 'backrub' motion. The team believes the subtle gyration influences proteins' activities in the cell. |
New Approach Offers Proof of Principle for Studying Membrane Proteins |
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October 18, 2005 • National Institute of General Medical SciencesResearchers led by Nobel Prize winner Roderick MacKinnon, M.D., of Rockefeller University have used yeast to express and obtain the structure of a mammalian voltage-dependent potassium ion channel—a type of membrane protein that helps transmit electrical signals into and out of heart and nerve cells. |
Split Beamlines Can Double Research Capacity at Advanced Photon Source |
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August 19, 2005 • Argonne National Laboratory |
UW-Madison Awarded $20 Million Grant for Protein Research |
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July 11, 2005 • Wisconsin Technology Network |
Innovative Protein-Analysis Center Funded at Los Alamos |
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July 11, 2005 • Los Alamos National Laboratory |
UW-Madison Scientists Receive $20 Million Award for Protein Study |
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July 6, 2005 • University of Wisconsin-Madison |
Columbia University Takes Leading Role in Second Phase of NIH Protein Structure Initiative |
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July 5, 2005 • Columbia University Medical Center |
Rutgers to Lead Project to Learn Protein Structures, Functions |
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July 5, 2005 • Rutgers University |
Protein Structure Initiative Advances to Rapid Production Phase |
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July 1, 2005 • National Institute of General Medical Sciences |
Scripps Research Institute-Based Center Awarded More than $50 Million by NIH in Massive Effort to Solve Protein Structures |
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July 1, 2005 • Scripps Research Institute |
Awards Announced for Protein Structures |
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July 1, 2005 • Science Now |
$50 Million Grant Will Aid Studies of Protein Structures |
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July 1, 2005 • Argonne National Laboratory |
Protein Structure Initiative Advances to Rapid Production Phase |
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July 1, 2005 • Brookhaven National Lab |
Structural GenomiX Receives $48.5 Million Award From NIH |
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July 1, 2005 • Structural GenomiX |
Research of Proteins Draw Major Funding |
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July 1, 2005 • San Diego Union Tribune |
Einstein Researchers Receive Major Federal Grant to Decipher the Three-Dimensional Shapes of Proteins |
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July 1, 2005 • Albert Einstein College of Medicine |
Researchers Debut New X-Ray Resources for Studying Molecules |
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June 23, 2005 • National Institute of General Medical Sciences |
The Shapes of Life: NIGMS Project Yields More Than 1,000 Protein Structures |
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February 10, 2005 • National Institute of General Medical SciencesThe Protein Structure Initiative, an NIGMS program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines. |
Scientists Develop Split Green for Tagging Protein |
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January 3, 2005 • Los Alamos National Laboratory |
Energy Secretary Recognizes Project Management Awardees |
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August 17, 2004 • Department of Energy |
Automated Science Speeds Solution of Human Genome Data |
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August 6, 2004 • Argonne National Laboratory |
Brookhaven Lab Biophysicist F. William Studier Wins R&D 100 Award for a New Method that Simplifies Protein Production |
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July 28, 2004 • Brookhaven National Laboratory |
Scientists Take 'Snapshot' of Molecular Tether for Anthrax and Staph Bacteria |
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July 19, 2004 • National Institute of General Medical Sciences |
Argonne Scientists Determine Structure of Staph, Anthrax Enzyme |
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July 14, 2004 • Argonne National Laboratory |
New Computational Tools to Aid in Protein Research |
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June 23, 2004 • Dartmouth College |
Crystallographers Take Note: a Synchrotron Light Source for Your Home Lab |
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April 16, 2004 • Lyncean Technologies, Inc. |
Robots Score Big with Protein Crystallographers |
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April 9, 2004 • Lawrence Berkeley National Laboratory |
'Crystal Engineering' Helps Scientists Solve 3-D Protein Structures |
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April 6, 2004 • National Institute of General Medical Sciences |
Dazzling New Light Source Opens at Stanford Synchrotron Radiation Laboratory |
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January 30, 2004 • Stanford University |
Protein Data Bank Opens New Era with Broader Support -- Nearly 24,000 Molecules and Growing, Accessible Collection Advances Biology |
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January 21, 2004 • National Science Foundation |
Anthrax Toxin Structure Solved |
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April 2, 2003 • National Institute of General Medical Sciences |
Protein Structure Initiative Center Maps Protein Universe |
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March 3, 2003 • National Institute of General Medical Sciences |
"Knot" to be Undone, Researchers Discover Unusual Protein Structure |
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November 26, 2002 • National Institute of General Medical Sciences |
Protein Structure Initiative |
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October 3, 2001 • National Institute of General Medical Sciences |
NIGMS Protein Structure Initiative Announces New Members |
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September 28, 2001 • National Institute of General Medical Sciences |
Structural Genomics: Inside the Cutting Edge |
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June 1, 2001 • National Institute of General Medical Sciences |
From Genes to Proteins: NIGMS Catalogs the Shapes of Life |
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February 20, 2001 • National Institute of General Medical Sciences |
NIGMS Structural Genomics Awards Scale Up Protein Structure Studies |
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September 26, 2000 • National Institute of General Medical Sciences |
Ten Thousand Protein Structures: The First Goal of Structural Genomics |
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June 2, 2000 • National Institute of General Medical Sciences |
NIGMS Announces Initiative on Structural Genomics |
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June 23, 1999 • National Institute of General Medical Sciences |