This page provides a current summary of the status of ongoing and completed NICEATM-ICCVAM alternative test
method evaluation projects, as well as projects to which NICEATM, ICCVAM,
and agency scientists are contributing.
Acute Oral Systemic Toxicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Up-and-Down Procedure |
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|
|
|
2002 |
2002 |
. |
Fixed Dose Procedure |
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2002 |
2002 |
. |
Acute Toxic Class Method |
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2002 |
2002 |
. |
In Vitro
Cytotoxicity Test Methods: 3T3 Cells |
|
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2008 |
In progress |
. |
In Vitro
Cytotoxicity Test Methods: NHK Cells |
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2008 |
In progress |
. |
Biologics and Vaccines Projects
|
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Use of Humane Endpoints in Animal Testing of Veterinary Products |
|
|
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2004 |
. |
. |
Use of Humane Endpoints in Animal Testing of Rabies Vaccines |
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2004 |
. |
. |
In Vivo Refinement Alternatives for Botulinum Toxin Potency Testing |
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. |
. |
. |
. |
. |
. |
Ex Vivo Alternatives for Botulinum Toxin Potency Testing |
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. |
. |
. |
. |
. |
. |
Cell-based Alternatives for Botulinum Toxin Potency Testing |
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. |
. |
. |
. |
. |
. |
Endopeptidase Assay Alternatives for Botulinum Toxin Potency Testing |
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. |
. |
. |
. |
. |
. |
Alternative Methods for Animal Vaccine Potency and Safety Testing |
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. |
. |
. |
. |
. |
. |
Dermal Corrosivity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Corrositex® Assay |
|
|
|
|
2000 |
2006 |
. |
EpiDermTM Assay |
|
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2004 |
2004 |
. |
EPISKINTM Assay |
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2004 |
2004 |
. |
Rat Transcutaneal Electrical Resistance Assay |
|
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2004 |
2004 |
. |
SkinEthic RHE Assay |
|
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|
2004 |
2004 |
. |
Dermal Irritation Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
EpiDermTM Assay |
|
|
In progress |
. |
. |
. |
. |
EPISKINTM Assay |
|
|
In progress |
. |
. |
. |
. |
SkinEthic RHE Assay |
|
|
In progress |
. |
. |
. |
. |
Developmental Toxicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Frog Embryo Teratogenesis Assay: Xenopus (FETAX) |
|
|
|
ICCVAM review in 2000
found that FETAX was not sufficiently reliable for regulatory use and provided recommendations
for improving accuracy and reliability |
Endocrine Disruptor Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
In vitro Andogen Receptor (AR) Binding |
|
ICCVAM review in 2004
found no adequately validated studies - ICCVAM published recommendations on future validation studies |
. |
In vitro AR Transcriptional Activation (TA) |
|
ICCVAM review in 2004
found no adequately validated studies - ICCVAM published recommendations on future validation studies |
. |
In vitro Estrogen Receptor (ER) Binding |
|
ICCVAM review in 2004
found no adequately validated studies - ICCVAM published recommendations on future validation studies |
. |
In vitro ER TA |
|
ICCVAM review in 2004
found no adequately validated studies - ICCVAM published recommendations on future validation studies |
. |
LUMICELL® ER TA Assay Evaluation |
|
In progress |
. |
. |
. |
. |
. |
MCF-7 Cell Proliferation Assay Evaluation |
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In progress |
. |
. |
. |
. |
. |
Genetic Toxicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
In Vitro Micronucleus Assay |
|
. |
. |
. |
. |
. |
In progress |
Immunotoxicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Murine Local Lymph Node Assay (LLNA) |
|
|
|
|
1999 |
2002 |
. |
Reduced LLNA Test Method |
|
|
In progress |
. |
. |
. |
. |
Nonradiolabeled LLNA Methods |
|
|
In progress |
. |
. |
. |
. |
Use of the LLNA for Skin Sensitization Potency Categorization |
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In progress |
. |
. |
. |
. |
Use of the LLNA for Testing Mixtures, Metals, and Aqueous Solutions |
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In progress |
. |
. |
. |
. |
Development of LLNA Performance Standards |
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|
In progress |
. |
. |
. |
. |
Ocular Toxicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
Bovine Corneal Opacity and Permeability (BCOP) - Ocular Corrosivity |
|
|
|
|
2008 |
In progress |
. |
Hen's Egg Test/Choriallantoic Membrane - Ocular Corrosivity (HET-CAM) |
|
|
|
|
ICCVAM review in 2008
found that HET-CAM was not sufficiently reliable for regulatory use and recommended
additional studies |
Isolated Chicken Eye (ICE) - Ocular Corrosivity |
|
|
|
|
2008 |
In progress |
. |
Isolated Rabbit Eye (IRE) - Ocular Corrosivity |
|
|
|
|
ICCVAM review in 2008
found that IRE was not sufficiently reliable for regulatory use and recommended
additional studies |
Integrated Nonanimal Testing Strategy for Eye Irritation Potential
of Antimicrobial Cleaning Products |
|
|
In progress |
. |
. |
. |
. |
BCOP - Mild to Moderate Ocular Irritation |
|
|
In progress |
. |
. |
. |
. |
HET-CAM - Mild to Moderate Ocular Irritation |
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In progress |
. |
. |
. |
. |
ICE - Mild to Moderate Ocular Irritation |
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In progress |
. |
. |
. |
. |
IRE - Mild to Moderate Ocular Irritation |
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In progress |
. |
. |
. |
. |
Fluorescein Leakage Test Method - Mild to Moderate Ocular Irritation |
|
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In progress |
. |
. |
. |
. |
Cytosensor Microphysiometer Test Method - Mild to Moderate Ocular Irritation |
|
|
In progress |
. |
. |
. |
. |
Neutral Red Release Test Method - Mild to Moderate Ocular Irritation |
|
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In progress |
. |
. |
. |
. |
Red Blood Cell Haemolysis Test Method - Mild to Moderate Ocular Irritation |
|
|
In progress |
. |
. |
. |
. |
Pyrogenicity Projects |
Test Method |
R&D |
Validation Studies |
Evaluation |
Recommendations for U.S. Agencies |
U.S. Acceptance |
International Acceptance |
Additional Activities |
The Human Whole Blood/IL-1 In Vitro Pyrogen Test |
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In progress |
. |
. |
The Human Whole Blood/ IL-1 In Vitro Pyrogen Test Using Cryopreserved Human Whole Blood |
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In progress |
. |
. |
The Human Whole Blood/IL-6 In Vitro Pyrogen Test (WB/IL-6) |
|
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In progress |
. |
. |
In Vitro Pyrogen Test Using Human Peripheral Blood Mononuclear Cells (PBMC/IL-6) |
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In progress |
. |
. |
An Alternative In Vitro Pyrogen Test Using the Human Monocytoid Cell Line MONO MAC 6 (MM6/IL-6) |
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In progress |
. |
. |
Up-And-Down Procedure
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged. The
Up-And-Down Procedure reduces animal use for this purpose by up to 70%. |
Milestone |
Date |
Document Link or More Information |
Publication of OECD Test Guideline 425 |
1998 |
PDF |
Nomination by the U.S. Environmental Protection Agency (EPA) |
August 1999 |
- |
Peer Review Panel Meeting |
July 2000 |
HTML |
Peer Review Panel Follow-up Teleconference |
August 2001 |
HTML |
Test Method Evaluation Report Published |
November 2001 |
Vol 1 -
Vol 2 |
Recommendations Made to Federal Agencies |
March 2003 |
HTML |
Federal Agency Responses Received |
December 2003 |
HTML |
Fixed Dose Procedure
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged. The
Fixed Dose Procedure reduces animal use for this purpose by up to 70%. |
Milestone |
Date |
Document Link or More Information |
Publication of OECD Test Guideline 420 |
1998 |
PDF |
Acute Toxic Class Method
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged. The
Acute Toxic Class Method reduces animal use for this purpose by up to 70%. |
Milestone |
Date |
Document Link or More Information |
Publication of OECD Test Guideline 423 |
1998 |
PDF |
Evaluation of In Vitro Cytotoxicity Test Methods
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged.
In Vitro Cytotoxicity Test Methods replace animal use for initial dose setting for these tests. |
Milestone |
Date |
Document Link or More Information |
EPA Nomination |
August 1999 |
- |
Workshop Held |
October 2000 |
HTML |
Guidance Document Published |
August 2001 |
PDF |
Workshop Report Published |
August 2001 |
PDF |
Recommendations Made to Federal Agencies |
March 2003 |
HTML |
Federal Agency Responses Received |
December 2003 |
HTML |
Validation Study of In Vitro Cytotoxicity Test Methods
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged.
Neutral Red Uptake Test Methods replace animal use for initial dose setting for these tests. |
Milestone |
Date |
Document Link or More Information |
Peer Review Panel Meeting |
May 2006 |
HTML |
Peer Review Panel Report Published |
June 2006 |
PDF |
Background Review Document Published |
November 2006 |
Vol 1
- Vol 2 |
Test Method Evaluation Report Published |
November 2006 |
HTML |
Recommendations Made to Federal Agencies |
March 2008 |
HTML |
Federal Agency Responses Received |
September 2008 |
HTML |
Developing and Advancing In Vitro Alternatives to Acute Chemical Systemic Toxicity Testing
Acute oral systemic toxicity testing identifies substances that are
poisonous when ingested so that they may be appropriately labeled and packaged.
An ICCVAM-sponsored workshop explored ways to reduce, refine, or replace animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Workshop Held |
February 2008 |
HTML |
Workshop Report Published |
Available online 2009 |
- |
Use of Humane Endpoints in Animal Testing of
Veterinary Products and Rabies Vaccines
Animal testing of biological products and rabies vaccines is performed
to ensure that each lot of these products is safe and effective.
A USDA directive refines animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
USDA Directive Published |
April 2004 |
PDF |
Alternative Methods for Botulinum Toxin Potency Testing
Animal testing of botulinum toxin is performed
to ensure that each lot of this product is safe and effective.
An ICCVAM-sponsored workshop explored ways to reduce, refine, or replace animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Nomination by the Humane Society of the United States |
October 2005 |
PDF |
Workshop Held |
November 2006 |
HTML |
Workshop Report Published |
February 2008 |
PDF |
Alternative Methods for Animal Vaccine Potency and Safety Testing
Animal testing of animal vaccines is performed
to ensure that each lot of these products is safe and effective.
An ICCVAM-sponsored workshop will explore ways to reduce, refine, or replace animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Workshop |
Planned Spring 2010 |
- |
Evaluation of Corrositex® for the
Identification of Substances Potentially Corrosive to Human Skin
Dermal corrosivity testing identifies substances that cause
chemical burns to the skin so that they may be appropriately labeled and packaged.
Corrositex® reduces and refines animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Corrositex® Submission |
May 1998 |
- |
Peer Review Panel Meeting |
January 1999 |
HTML |
Peer Review Panel Report Published |
June 1999 |
PDF |
Recommendations Made to Federal Agencies |
June 1999 |
- |
Federal Agency Responses Received |
October 1999 |
HTML |
Publication of OECD Test Guideline 435 |
July 2006 |
PDF |
Evaluation of EpiSkinTM,
EPIDERMTM and the Rat Skin Transcutaneous Electrical Resistance Assay (TER) for the
Identification of Substances Potentially Corrosive to Human Skin
Dermal corrosivity testing identifies substances that cause
chemical burns to the skin so that they may be appropriately labeled and packaged.
Use of these in vitro tests reduces and refines animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Background Review Document Published |
August 2001 |
PDF |
Test Method Evaluation Report Published |
June 2002 |
HTML |
Recommended Performance Standards Published |
May 2004 |
PDF |
Publication of OECD Test Guidelines 430 and 431 |
July 2006 |
TG 430 - PDF
TG 431 - PDF |
Evaluation of EpiSkinTM,
EPIDERMTM and the SkinEthic RHE Assay for the
Identification of Substances Potentially Irritating to Human Skin
Dermal irritation testing identifies substances that cause
irritation to the skin so that they may be appropriately labeled and packaged.
Use of these in vitro tests reduces animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Submission of ICCVAM Comments on Draft Test Guideline to U.S. OECD National Coordinator |
August 2008 |
HTML |
OECD Expert Meeting |
Scheduled for June 2009 |
- |
Frog Embryo Teratogenesis Assay:
Xenopus (FETAX)
Developmental toxicity testing identifies substances that may cause
birth defects so that they may be appropriately labeled.
Use of FETAX could reduce or replace animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
EPA Nomination |
May 1998 |
- |
Background Review Document Published |
March 2000 |
HTML |
Expert Panel Meeting |
May 2000 |
PDF |
Evaluation of In Vitro ER and AR Binding and TA Assays
Endocrine disruptor testing identifies substances that may
interfere with normal human and animal development.
Use of in vitro tests could reduce animal use for this purpose in the EPA Endocrine Disruptor Screening Program (EDSP). |
Milestone |
Date |
Document Link or More Information |
EPA Nomination |
April 2000 |
- |
Expert Panel Meeting |
May 2002 |
HTML |
Expert Panel Report |
September 2002 |
PDF |
Background Review Documents Published |
October 2002 |
HTML |
Test Method Evaluation Report Published |
May 2003 |
HTML |
Addendum to Test Method Evaluation Report Published |
September 2006 |
PDF |
Xenobiotic Detection Systems, Inc. LUMICELL® ER Assay Validation Study
Endocrine disruptor testing identifies substances that may
interfere with normal human and animal development.
Use of the LUMICELL® ER Assay could reduce animal use for this purpose in the EPA EDSP. |
Milestone |
Date |
Document Link or More Information |
LUMICELL® ER Assay Nomination |
January 2004 |
PDF |
Draft Pre-Screen Evaluation Released |
August 2004 |
PDF |
Submission of the Standard Project Submission Form
to the OECD Test Guidelines Program:
Stably Transfected Transcriptional Activation Assay
for the Detection of Estrogen Receptor Agonists and Antagonists |
September 2007 |
PDF |
Validation Study Initiated |
November 2007 |
HTML |
Peer Review of Draft Background Review Document and Draft ICCVAM Test Method Recommendations |
Projected September 2009 |
- |
CertiChem Inc. MCF-7 Cell Proliferation Assay Evaluation
Endocrine disruptor testing identifies substances that may
interfere with normal human and animal development.
Use of the MCF-7 Cell Proliferation Assay could reduce animal use for this purpose in the EPA EDSP. |
Milestone |
Date |
Document Link or More Information |
MCF-7 Cell Proliferation Assay Nomination |
June 2004 |
PDF |
Pre-Screen Evaluation Released |
October 2006 |
PDF |
Draft Test Guideline for the In Vitro Mammalian Cell Micronucleus Test
Genetic toxicity testing identifies substances that may
cause DNA damage and increase risk of cancer or birth defects.
Use of the In Vitro Mammalian Cell Micronucleus Test could reduce animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Submission of ICCVAM Comments on Draft Test Guideline to U.S. OECD National Coordinator |
February 2007 |
HTML |
Murine Local Lymph Node Assay (LLNA)
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
Use of the LLNA reduces and refines animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Nomination by Sponsors |
January 1998 |
- |
Peer Review Panel Meeting |
September 1998 |
HTML |
Peer Review Panel Report |
February 1999 |
PDF |
Recommendations Made to Federal Agencies |
February 1999 |
HTML |
Publication of OECD Test Guideline 429 |
July 2006 |
PDF |
Development of Performance Standards for the Murine Local
Lymph Node Assay (LLNA)
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
Accepted performance standards will enable the development of new versions of the LLNA for this purpose. |
Milestone |
Date |
Document Link or More Information |
CPSC Nomination |
January 2007 |
PDF |
Draft Performance Standards Published |
September 2007 |
PDF |
Peer Review Panel Meeting |
March 2008 |
HTML |
Peer Review Panel Report Published |
May 2008 |
PDF |
Finalized ICCVAM Performance Standards Published |
April 2009 |
HTML |
Reduced Murine Local Lymph Node Assay (LLNA)
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
The reduced LLNA will reduce animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
CPSC Nomination |
January 2007 |
PDF |
Peer Review Panel Meeting |
March 2008 |
HTML |
Peer Review Panel Report Published |
May 2008 |
PDF |
Test Method Evaluation Report Published |
Projected early 2009 |
HTML |
Nonradioactive Murine Local Lymph Node Assay (LLNA)
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
Nonradioactive version of the LLNA will refine and reduce animal use for this purpose
by enabling more widespread use of the LLNA. |
Milestone |
Date |
Document Link or More Information |
CPSC Nomination |
January 2007 |
PDF |
Peer Review Panel Meeting |
March 2008 |
HTML |
Peer Review Panel Report Published |
May 2008 |
PDF |
Revised Background Review Documents and ICCVAM Recommendations Published |
March 2009 |
HTML |
Second Peer Review Panel Meeting |
April 2009 |
HTML |
Use of the Murine Local Lymph Node Assay (LLNA)
for Skin Sensitization Potency Categorization
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
Use of the LLNA will refine and reduce animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
CPSC Nomination |
January 2007 |
PDF |
Peer Review Panel Meeting |
March 2008 |
HTML |
Peer Review Panel Report Published |
May 2008 |
PDF |
Use of the Murine Local Lymph Node Assay (LLNA)
for Testing Mixtures, Metals, and Aqueous Solutions
Immunotoxicity testing identifies substances that may
act as sensitizers and cause the development of allergic contact dermatitis.
Use of the LLNA will refine and reduce animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
CPSC Nomination |
January 2007 |
PDF |
Peer Review Panel Meeting |
March 2008 |
HTML |
Peer Review Panel Report Published |
May 2008 |
PDF |
Revised Background Review Documents and ICCVAM Recommendations Published |
March 2009 |
HTML |
Second Peer Review Panel Meeting |
April 2009 |
HTML |
In Vitro Test Methods for Detecting Ocular Corrosives and Severe Irritants
- Bovine Corneal Opacity and Permeability Test Method
- Isolated Chicken Eye Test Method
- Isolated Rabbit Eye Test Method
- Hen's Egg Test - Chorioallantoic Membrane Test Method
Ocular toxicity testing identifies substances that may
cause permanent or temporary blindness.
Use of these in vitro test methods will reduce and refine animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
EPA Nomination |
October 2003 |
- |
Expert Panel Meeting |
January 2005 |
HTML |
Expert Panel Report |
March 2005 |
PDF |
Expert Panel Teleconference |
September 2005 |
HTML |
Expert Panel Report Addendum |
November 2005 |
PDF |
Background Review Documents Published |
October 2007 |
HTML |
Test Method Evaluation Report Published |
October 2007 |
HTML |
Recommendations Made to Federal Agencies |
October 2007 |
HTML |
Federal Agency Responses Received |
May 2008 |
HTML |
Draft OECD Test Guidelines Submitted to U.S. National Coordinator |
August 2008 |
HTML |
In Vitro Test Methods for Detecting Nonsevere Ocular Irritants
- Bovine Corneal Opacity and Permeability Test Method
- Isolated Chicken Eye Test Method
- Isolated Rabbit Eye Test Method
- Hen's Egg Test - Chorioallantoic Membrane Test Method
Ocular toxicity testing identifies substances that may
cause irritation to the eye.
Use of these In Vitro Test Methods will reduce and refine animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
EPA Nomination |
October 2003 |
- |
Peer Review Panel Meeting |
May 2009 |
HTML |
In Vitro Test Methods for Detecting Nonsevere Ocular Irritants
- Cytosensor Microphysiometer Test Method
- Fluorescein Leakage Test Method
- Neutral Red Release Test Method
- Red Blood Cell Haemolysis Test Method
Ocular toxicity testing identifies substances that may
cause irritation to the eye.
Use of these In Vitro Test Methods will reduce and refine animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
ICCVAM Working Group Comment on Background Review Documents submitted
the European Committee for the Validation of Alternative Methods |
July 2008 |
- |
Nonanimal Assessment Approach for
Evaluating Eye Irritation Potential of Antimicrobial Cleaning Products
Ocular toxicity testing identifies substances that may
cause irritation to the eye.
Use of this in vitro approach could replace animal use for this purpose
to meet EPA labeling requirements. |
Milestone |
Date |
Document Link or More Information |
Submission by IIVS |
January 2008 |
PDF |
Peer Review Panel Meeting |
May 2009 |
HTML |
In Vitro Pyrogen Test Methods
- The Human Whole Blood/IL-1 In Vitro Pyrogen Test
- The Human Whole Blood/ IL-1 In Vitro Pyrogen Test Using Cryopreserved Human Whole Blood
- The Human Whole Blood/IL-6 In Vitro Pyrogen Test (WB/IL-6)
- In Vitro Pyrogen Test Using Human Peripheral Blood Mononuclear Cells (PBMC/IL-6)
- An Alternative In Vitro Pyrogen Test Using the Human Monocytoid Cell Line MONO MAC 6 (MM6/IL-6)
Pyrogenicity testing is performed
on products to be administered by injection to ensure that each lot of these products
is free of substances that could induce a dangerous fever reaction.
Use of these in vitro tests could replace animal use for this purpose. |
Milestone |
Date |
Document Link or More Information |
Submission by ECVAM |
June 2005 |
PDF |
Peer Review Panel Meeting |
February 2007 |
HTML |
Peer Review Panel Report Published |
April 2007 |
PDF |
Background Review Document Published |
October 2008 |
HTML |
Test Method Evaluation Report Published |
October 2008 |
HTML |
Recommendations to Federal Agencies |
November 2008 |
HTML |