Vascular Zip Codes in Targeted Delivery of Multifunctional Nanodevices |
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| Launch in standalone player | |
| Air date: | Wednesday, April 29, 2009, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | This laboratory screens phage libraries in live mice to identify peptides that direct phage homing to a specific target in the body. When the libraries are injected into the circulation, tissue-specific or tumor-specific differences in endothelial cells are primarily targeted.
We have identified tumor-homing peptides that recognize angiogenesis-associated or tumor-type specific markers in tumor blood vessels, or distinguish the vessels of pre-malignant lesions from those of the corresponding normal tissues and of fully malignant tumors. Homing peptides have also revealed a zip code system of molecular changes in tumor lymphatics. We have used synthetic homing peptides identified by phage display to target nanoparticles to tumors. The vasculature is an excellent target because blood supply is important for tumor growth and because tumor vessels are readily available for circulating particles. The homing peptides deliver nanoparticles into tumors in a highly selective manner, and we have developed a nanoparticle that amplifies its own homing to tumors. Quite recently, we have discovered peptides that specifically home to tumor vessels, extravasate, enter into cells, and spread within tumor tissue. These tumor-penetrating peptides are capable of taking a payload, such as nanoparticles, deep into tumor tissue. We have elucidated the molecular pathway for the cell and tissue penetration by these peptides. We are using these peptides to construct multifunctional, targeted nanoparticles that also serve as tumor imaging probes and drug carriers. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Erkki Ruoslahti |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 15076 |
| CIT Live ID: | 7043 |
| Permanent link: | http://videocast.nih.gov/launch.asp?15076 |
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Enhanced Audio Podcast | 1:01:41 |
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Enhanced Video Podcast | 1:01:41 | |