| | Other Issues: previous | next | latest | archiveBiological Perspectives Physiological, Pathological, and Therapeutic Implications of Zonulin-Mediated Intestinal Barrier Modulation : Living Life on the Edge of the Wall Alessio Fasano Am J Pathol. 2008 November; 173(5): 1243–1252. doi: 10.2353/ajpath.2008.080192.PMCID: PMC2570116 Review Inflammation at the Molecular Interface of Atherogenesis : An Anthropological Journey Brian D. Lamon and David P. Hajjar Am J Pathol. 2008 November; 173(5): 1253–1264. doi: 10.2353/ajpath.2008.080442.PMCID: PMC2570117 Regular Articles Cardiovascular, Pulmonary and Renal Pathology A Mutation in Rab38 Small GTPase Causes Abnormal Lung Surfactant Homeostasis and Aberrant Alveolar Structure in Mice Kazuhiro Osanai, Rieko Oikawa, Junko Higuchi, Makoto Kobayashi, Katsuma Tsuchihara, Masaharu Iguchi, Huang Jongsu, Hirohisa Toga, and Dennis R. Voelker Am J Pathol. 2008 November; 173(5): 1265–1274. doi: 10.2353/ajpath.2008.080056.PMCID: PMC2570118 Transforming Growth Factor-β Regulates in Vitro Heart Valve Repair by Activated Valve Interstitial Cells Amber C. Liu and Avrum I. Gotlieb Am J Pathol. 2008 November; 173(5): 1275–1285. doi: 10.2353/ajpath.2008.080365.PMCID: PMC2570119 Lipid Droplet-Associated Proteins Protect Renal Tubular Cells from Fatty Acid-Induced Apoptosis Yoshimichi Urahama, Yuki Ohsaki, Yutaka Fujita, Shoichi Maruyama, Yukio Yuzawa, Seiichi Matsuo, and Toyoshi Fujimoto Am J Pathol. 2008 November; 173(5): 1286–1294. doi: 10.2353/ajpath.2008.080137.PMCID: PMC2570120 Cell Injury, Repair, Aging and Apoptosis Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice Ekaterina Semenova, Heidi Koegel, Sybille Hasse, Jennifer E. Klatte, Esfir Slonimsky, Daniel Bilbao, Ralf Paus, Sabine Werner, and Nadia Rosenthal Am J Pathol. 2008 November; 173(5): 1295–1310. doi: 10.2353/ajpath.2008.071177.PMCID: PMC2570121 Adenoviral Overexpression and Small Interfering RNA Suppression Demonstrate That Plasminogen Activator Inhibitor-1 Produces Elevated Collagen Accumulation in Normal and Keloid Fibroblasts Tai-Lan Tuan, Paul Hwu, Wendy Ho, Peter Yiu, Richard Chang, Annette Wysocki, and Paul D. Benya Am J Pathol. 2008 November; 173(5): 1311–1325. doi: 10.2353/ajpath.2008.080272.PMCID: PMC2570122 Inhibition of Nuclear Translocation of Apoptosis-Inducing Factor Is an Essential Mechanism of the Neuroprotective Activity of Pigment Epithelium-Derived Factor in a Rat Model of Retinal Degeneration Yusuke Murakami, Yasuhiro Ikeda, Yoshikazu Yonemitsu, Mitsuho Onimaru, Kazunori Nakagawa, Ri-ichiro Kohno, Masanori Miyazaki, Toshio Hisatomi, Makoto Nakamura, Takeshi Yabe, Mamoru Hasegawa, Tatsuro Ishibashi, and Katsuo Sueishi Am J Pathol. 2008 November; 173(5): 1326–1338. doi: 10.2353/ajpath.2008.080466.PMCID: PMC2570123 Epithelial and Mesenchymal Cell Biology Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface Julie Ann Mayer, John Foley, Damon De La Cruz, Cheng-Ming Chuong, and Randall Widelitz Am J Pathol. 2008 November; 173(5): 1339–1348. doi: 10.2353/ajpath.2008.070920.PMCID: PMC2570124 CGI-58 Is an α/β-Hydrolase within Lipid Transporting Lamellar Granules of Differentiated Keratinocytes Masashi Akiyama, Kaori Sakai, Chitoshi Takayama, Teruki Yanagi, Yasuko Yamanaka, James R. McMillan, and Hiroshi Shimizu Am J Pathol. 2008 November; 173(5): 1349–1360. doi: 10.2353/ajpath.2008.080005.PMCID: PMC2570125 Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1 Sudip K. Bandyopadhyay, Carol A. de la Motte, Sean P. Kessler, Vincent C. Hascall, David R. Hill, and Scott A. Strong Am J Pathol. 2008 November; 173(5): 1361–1368. doi: 10.2353/ajpath.2008.080444.PMCID: PMC2570126 Immunopathology and Infectious Diseases CD34+ Cord Blood Cell-Transplanted Rag2−/− γc−/− Mice as a Model for Epstein-Barr Virus Infection Mario Cocco, Cristiana Bellan, Roxane Tussiwand, Davide Corti, Elisabetta Traggiai, Stefano Lazzi, Susanna Mannucci, Lucio Bronz, Nazzareno Palummo, Chiara Ginanneschi, Piero Tosi, Antonio Lanzavecchia, Markus G. Manz, and Lorenzo Leoncini Am J Pathol. 2008 November; 173(5): 1369–1378. doi: 10.2353/ajpath.2008.071186.PMCID: PMC2570127 Stress-Induced Neurogenic Inflammation in Murine Skin Skews Dendritic Cells Towards Maturation and Migration : Key Role of Intercellular Adhesion Molecule-1/Leukocyte Function-Associated Antigen Interactions Ricarda Alcira Joachim, Bori Handjiski, Sandra Maria Blois, Evelin Hagen, Ralf Paus, and Petra Clara Arck Am J Pathol. 2008 November; 173(5): 1379–1388. doi: 10.2353/ajpath.2008.080105.PMCID: PMC2570128 Foxp3+ T-Regulatory Cells in Sjögren’s Syndrome : Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors Maria I. Christodoulou, Efstathia K. Kapsogeorgou, Niki M. Moutsopoulos, and Haralampos M. Moutsopoulos Am J Pathol. 2008 November; 173(5): 1389–1396. doi: 10.2353/ajpath.2008.080246.PMCID: PMC2570129 Up-Regulation of Activating Transcription Factor-5 Suppresses SAP Expression to Activate T Cells in Hemophagocytic Syndrome Associated with Epstein-Barr Virus Infection and Immune Disorders Huai-Chia Chuang, Ju-Ming Wang, Wen-Chuan Hsieh, Yao Chang, and Ih-Jen Su Am J Pathol. 2008 November; 173(5): 1397–1405. doi: 10.2353/ajpath.2008.080440.PMCID: PMC2570130 Human Autoantibodies Specific for Neurotrophin Receptors TrkA, TrkB, and TrkC Protect against Lethal Trypanosoma cruzi Infection in Mice Bo Lu, Joseph Alroy, Alejandro O. Luquetti, and Mercio PereiraPerrin Am J Pathol. 2008 November; 173(5): 1406–1414. doi: 10.2353/ajpath.2008.080514.PMCID: PMC2570131 Interaction of the Lyme Disease Spirochete Borrelia burgdorferi with Brain Parenchyma Elicits Inflammatory Mediators from Glial Cells as Well as Glial and Neuronal Apoptosis Geeta Ramesh, Juan T. Borda, Jason Dufour, Deepak Kaushal, Ramesh Ramamoorthy, Andrew A. Lackner, and Mario T. Philipp Am J Pathol. 2008 November; 173(5): 1415–1427. doi: 10.2353/ajpath.2008.080483.PMCID: PMC2570132 Shiga Toxin-Mediated Disease in MyD88-Deficient Mice Infected with Escherichia coli O157:H7 Carla Calderon Toledo, Trisha Jayne Rogers, Majlis Svensson, Ramesh Tati, Hans Fischer, Catharina Svanborg, and Diana Karpman Am J Pathol. 2008 November; 173(5): 1428–1439. doi: 10.2353/ajpath.2008.071218.PMCID: PMC2570133 Tolerance to Melanin-Associated Antigen in Autoimmune Uveitis Is Mediated by CD4+CD25+ T-Regulatory Cells Bharati Matta, Purushottam Jha, Puran S. Bora, and Nalini S. Bora Am J Pathol. 2008 November; 173(5): 1440–1454. doi: 10.2353/ajpath.2008.080150.PMCID: PMC2570134 Molecular Pathogenesis of Genetic and Inherited Diseases Sall1, Sall2, and Sall4 Are Required for Neural Tube Closure in Mice Johann Böhm, Anja Buck, Wiktor Borozdin, Ashraf U. Mannan, Uta Matysiak-Scholze, Ibrahim Adham, Walter Schulz-Schaeffer, Thomas Floss, Wolfgang Wurst, Jürgen Kohlhase, and Francisco Barrionuevo Am J Pathol. 2008 November; 173(5): 1455–1463. doi: 10.2353/ajpath.2008.071039.PMCID: PMC2570135 Defect of Hepatocyte Growth Factor Activator Inhibitor Type 1/Serine Protease Inhibitor, Kunitz Type 1 (Hai-1/Spint1) Leads to Ichthyosis-Like Condition and Abnormal Hair Development in Mice Koki Nagaike, Makiko Kawaguchi, Naoki Takeda, Tsuyoshi Fukushima, Akira Sawaguchi, Kazuyo Kohama, Mitsuru Setoyama, and Hiroaki Kataoka Am J Pathol. 2008 November; 173(5): 1464–1475. doi: 10.2353/ajpath.2008.071142.PMCID: PMC2570136 Dysferlin Deficiency Shows Compensatory Induction of Rab27A/Slp2a That May Contribute to Inflammatory Onset Akanchha Kesari, Mitsunori Fukuda, Susan Knoblach, Rumaisa Bashir, Gustavo A. Nader, Deepak Rao, Kanneboyina Nagaraju, and Eric P. Hoffman Am J Pathol. 2008 November; 173(5): 1476–1487. doi: 10.2353/ajpath.2008.080098.PMCID: PMC2570137 Neurobiology Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer’s Disease Natalia Louneva, Julia W. Cohen, Li-Ying Han, Konrad Talbot, Robert S. Wilson, David A. Bennett, John Q. Trojanowski, and Steven E. Arnold Am J Pathol. 2008 November; 173(5): 1488–1495. doi: 10.2353/ajpath.2008.080434.PMCID: PMC2570138 Flupirtine as Neuroprotective Add-On Therapy in Autoimmune Optic Neuritis Muriel B. Sättler, Sarah K. Williams, Clemens Neusch, Markus Otto, Jens R. Pehlke, Mathias Bähr, and Ricarda Diem Am J Pathol. 2008 November; 173(5): 1496–1507. doi: 10.2353/ajpath.2008.080491.PMCID: PMC2570139 Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-γ Wensheng Lin, Phillip E. Kunkler, Heather P. Harding, David Ron, Richard P. Kraig, and Brian Popko Am J Pathol. 2008 November; 173(5): 1508–1517. doi: 10.2353/ajpath.2008.080449.PMCID: PMC2570140 Tumorigenesis and Neoplastic Progression Specific Mutations in the β-Catenin Gene (CTNNB1) Correlate with Local Recurrence in Sporadic Desmoid Tumors Alexander J.F. Lazar, Daniel Tuvin, Shohrae Hajibashi, Sultan Habeeb, Svetlana Bolshakov, Empar Mayordomo-Aranda, Carla L. Warneke, Dolores Lopez-Terrada, Raphael E. Pollock, and Dina Lev Am J Pathol. 2008 November; 173(5): 1518–1527. doi: 10.2353/ajpath.2008.080475.PMCID: PMC2570141 Keratinocyte Expression of MMP3 Enhances Differentiation and Prevents Tumor Establishment Lisa J. McCawley, Jane Wright, Bonnie J. LaFleur, Howard C. Crawford, and Lynn M. Matrisian Am J Pathol. 2008 November; 173(5): 1528–1539. doi: 10.2353/ajpath.2008.080132.PMCID: PMC2570142 Focal Adhesion Kinase-Related Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase Are Co-Overexpressed in Early-Stage and Invasive ErbB-2-Positive Breast Cancer and Cooperate for Breast Cancer Cell Tumorigenesis and Invasiveness Emy Behmoaram, Krikor Bijian, Su Jie, Yingjie Xu, Andrew Darnel, Tarek A. Bismar, and Moulay A. Alaoui-Jamali Am J Pathol. 2008 November; 173(5): 1540–1550. doi: 10.2353/ajpath.2008.080292.PMCID: PMC2570143 Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer Paolo P. Provenzano, David R. Inman, Kevin W. Eliceiri, Hilary E. Beggs, and Patricia J. Keely Am J Pathol. 2008 November; 173(5): 1551–1565. doi: 10.2353/ajpath.2008.080308.PMCID: PMC2570144 Vascular Biology, Atherosclerosis and Endothelium Biology Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions Tae Nakasaki, Toshiyuki Tanaka, Shinichi Okudaira, Michi Hirosawa, Eiji Umemoto, Kazuhiro Otani, Soojung Jin, Zhongbin Bai, Haruko Hayasaka, Yoshinori Fukui, Katsuyuki Aozasa, Naoya Fujita, Takashi Tsuruo, Keiichi Ozono, Junken Aoki, and Masayuki Miyasaka Am J Pathol. 2008 November; 173(5): 1566–1576. doi: 10.2353/ajpath.2008.071153.PMCID: PMC2570145 Regulation of the Atheroma-Enriched Protein, SPRR3, in Vascular Smooth Muscle Cells through Cyclic Strain is Dependent on Integrin α1β1/Collagen Interaction Amy L. Pyle, James B. Atkinson, Ambra Pozzi, Jeff Reese, Beate Eckes, Jeffrey M. Davidson, Dan L. Crimmins, and Pampee P. Young Am J Pathol. 2008 November; 173(5): 1577–1588. doi: 10.2353/ajpath.2008.080042.PMCID: PMC2570146 Correspondence Vitamin D May Reduce Prostate Cancer Metastasis by Several Mechanisms Including Blocking Stat3 Am J Pathol. 2008 November; 173(5): 1589–1590. doi: 10.2353/ajpath.2008.080579.PMCID: PMC2570147 |