Protocol Number: 07-CC-0153

Title:

Effects of Peripheral Blood Stem Cell Transplantation on the Microbial Flora of the Oral Cavity

Number:

07-CC-0153

Summary:

This study will examine bacteria in patients' mouths at different times during stem cell transplantation and recovery. Drugs patients receive as part of the conditioning process for a stem cell transplant increase their risk of infection. There might be a link between the bacteria in the mouth and the bacteria that can cause infections. Knowing the changes in bacteria might help researchers determine the best method to prevent infections.

Patients 18 years of age and older who are scheduled to receive a stem cell transplant may be eligible for this study.

Participants undergo the following procedures:

Review of medical records

Interview about their oral care

Oral examination

Collection of oral specimens just before the stem cell transplant, immediately after the transplant, and 3 weeks after the transplant. The specimens are obtained as follows:

? -About one-fourth teaspoon of saliva is collected with a suction device similar to that used in a dental office.

? -Plaque from the surface of a tooth is collected with a plastic toothpick.

? -Skin cells from the inside of the cheek and the surface of the tongue are collected with a small soft brush.

? -If a tube is inserted into the patient's lungs to assist breathing and the patient is admitted to the intensive care unit, a specimen from the lungs is collected.

Patients are followed for 100 days after their transplant. Additional oral specimens are obtained from those who develop signs and symptoms of respiratory infection.

Sponsoring Institute:

National Institutes of Health Clinical Center (CC)

Recruitment Detail

Type: No longer recruiting/follow-up only

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Oral Microbial Flora

Allogeneic PBSCT

Recruitment Keyword(s):

Oral Microbial Flora

Allogeneic Stem Cell Transplant

Condition(s):

Allogeneic Peripheral Blood Stem Cell Transplant

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

Warren G. Magnuson Clinical Center

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005;38:135-87. Review. No abstract available.

Mager DL, Ximenez-Fyvie LA, Haffajee AD, Socransky SS. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol. 2003 Jul;30(7):644-54.

Kolenbrander PE, Andersen RN, Blehert DS, Egland PG, Foster JS, Palmer RJ Jr. Communication among oral bacteria. Microbiol Mol Biol Rev. 2002 Sep;66(3):486-505, table of contents.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department Clinical Research Informatics, CC.

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