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Protocol Number:
99-M-0166
- Title:
Investigation of Brain Function During Eyeblink Responding in Normal Volunteers and Patients with Schizophrenia (A Study of Behavior and Evoked Potentials)
- Number:
99-M-0166
- Summary:
The purpose of this study is to explore how the brain works during particular memory tasks in people with schizophrenia and healthy volunteers.
Research has shown that patients with schizophrenia have structural and functional abnormalities in the hippocampus and cerebellum of their brains. These abnormalities are likely associated with the memory impairment experienced by these patients. Eye blink tests can provide information about memory acquisition involving the cerebellar and hippocampal regions. By altering the stimuli interval, these tests can distinguish between cerebellum-dependent memory associated with subliminal mnemonic encoding and hippocampus-dependent memory associated with conscious awareness. This study will use eyeblink tests to determine which type of memory is predominantly affected in schizophrenia.
Participants in this study will be screened with a physical and psychiatric examination. Participants will have an electroencephalogram (EEG), an electrocardiogram (ECG), and an electrodermal test. Evoked potentials and magnetic resonance imaging (MRI) scans of the brain may also be taken.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Subjects will be compensated for their time.
- Keyword(s):
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Schizophrenia
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Eyeblink
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Evoked Potentials
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Learning
- Recruitment Keyword(s):
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Normal Volunteer
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Schizophrenia
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Healthy Volunteer
- Condition(s):
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Healthy
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Schizophrenia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
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National Institute of Mental Health
- Contact(s):
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Woodruff-Pak DS. Classical conditioning. Int Rev Neurobiol. 1997;41:341-66. Review.
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Chen L, Bao S, Lockard JM, Kim JK, Thompson RF. Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. J Neurosci. 1996 Apr 15;16(8):2829-38.
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Daum I, Schugens MM, Ackermann H, Lutzenberger W, Dichgans J, Birbaumer N. Classical conditioning after cerebellar lesions in humans. Behav Neurosci. 1993 Oct;107(5):748-56.
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Bethesda, Maryland 20892. Last update: 05/05/2009
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