INCLUSION CRITERIA:
Ability to sign informed consent
Healthy male or female between 18-65 years of age
Willing to have samples stored for future research
EXCLUSION CRITERIA:
History of asthma or other allergic diseases
History of an immune deficiency, such as HIV infection or cancer
History of chronic hepatitis B and/or C infection
History of anemia
A known clotting disorder or taking medications that interfere with blood clotting, such as: aspirin, heparin, or Coumadin*
Current pregnancy
History of allergy to lidocaine
Have taken an investigational drug in the last 6 months
Apheresis in the past 6 weeks
Any other medical condition that the investigator feels puts the participant at too high a risk for participation
* Coumadin and/or heparin treatment will not be stopped so that a subject can participate in this protocol. If Coumadin or heparin was recently discontinued, a subject can be enrolled, but no bone marrow procedures will be performed until the prothrombin time is less than 15.5 seconds and the partial thromboplastin time is within normal range. For other agents that interfere with blood clotting without prolonging the prothrombin time, a 7-day washout period will be required before bone marrow sampling.
National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 05/05/2009