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Protocol Number:
07-M-0082
- Title:
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203
- Number:
07-M-0082
- Summary:
The metabotropic glutamate subtype five (mGluR5) receptor is a protein found in the brain and is the target for the excitatory chemical messenger glutimate. The purpose of this protocol is to measure mGluR5 receptors in the brain using positron emission tomography (PET) and a research drug called [18F]SP203.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
Yes
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Healthy control subjects aged 18-65 years, with history/physical exam, ECG, and laboratory tests within one year of the PET scan within normal limits.
EXCLUSION CRITERIA:
1. Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.
2. Laboratory tests with clinically significant abnormalities.
3. Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits.
4. Pregnancy and breast feeding.
5. Claustrophobia. (part 1 only)
6. Presence of ferromagnetic metal in the body or heart pacemaker. (part 1 only)
7. Positive HIV test.
8. Consumed alcohol within 48 hours before the PET scan.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Pharmacokinetics
-
Binding Potential
-
Glutamate
-
Positron Emission Tomography
-
Metabolic Glutamate Receptors
- Recruitment Keyword(s):
-
Healthy Volunteer
-
HV
- Condition(s):
-
Healthy
-
Glutamate Receptor
-
mGlur5 Protein
-
Excitatory Amino Acid Receptors
-
Drug Kinetics
-
PET Scan
- Investigational Drug(s):
-
[18F]SP203
- Investigational Device(s):
- None
- Intervention(s):
-
Drug: [18F]SP203
- Supporting Site:
- National Institute of Mental Health
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Brodkin J, Bradbury M, Busse C, Warren N, Bristow LJ, Varney MA. Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur J Neurosci. 2002 Dec;16(11):2241-4.
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Cosford ND, Roppe J, Tehrani L, Schweiger EJ, Seiders TJ, Chaudary A, Rao S, Varney MA. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4.
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Fujita M, Seibyl JP, Verhoeff NP, Ichise M, Baldwin RM, Zoghbi SS, Burger C, Staley JK, Rajeevan N, Charney DS, Innis RB. Kinetic and equilibrium analyses of [(123)I]epidepride binding to striatal and extrastriatal dopamine D(2) receptors. Synapse. 1999 Dec 15;34(4):290-304.
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Bethesda, Maryland 20892. Last update: 05/05/2009
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