Protocol Number: 07-DK-0077 ![]()
People over 18 years of age from all weight categories (lean, overweight, obese) who are reasonably healthy may be eligible for this study. Participants undergo the following tests and procedures: -Physical exam, electrocardiogram, blood and urine tests, instructions for recording food intake for 7 days -Metabolic studies for menstruating women. -Resting metabolic rate to study how many calories the body burns at rest. -Mixed meal test to measure hormones such as insulin that regulate blood sugar. -Glucose tolerance test to determine how sensitive the body is to insulin. -24-hour energy expenditure to measure the amount of oxygen breathed in and the amount of carbon dioxide breathed out. -Repeat 24-hour energy expenditure. -Diurnal blood sampling and temperature assessment to study the body's internal clock. -Air-displacement plethysmography (Bod Pod) to measure body composition. -Dual energy x-ray absortiometry (DEXA) to measure body fat and bone density. -Repeat Bod Pod and DEXA. -Anthropometric measurements and bioelectrical impedance to measure height, weight, and circumferences, skinfold thickness, fluid status and percentage body fat. -Bromide dilution to measure the amount of water not in cells in the body. -Doubly labeled water to measure the amount of calories burned in a 7-day period. -24-hour diet reports. -Endothelial reactivity to measure how the blood vessels stretch or dilate for assessing cardiovascular health. -Treadmill or bicycle exercise capacity test. -Physical activity monitor. -Unicorder to detect any breathing difficulties that may interfere with sleep. -Fat and muscle biopsy to look for variations in gene expression in fat tissue and muscle. -Neurocognitive testing to check memory, decision-making, hand-eye coordination, and reasoning. -Evaluation of mood problems and assess personality type. -Evaluation to assess the quantity and quality of pain experienced. -Taste testing to determine the response to bitter, salty, sweet and sour substances. -Occupational therapy evaluation to explore the subject's adaptations, if any, for performing personal, social or professional activities; the subject's views on his or her weight, body size and shape, and strategies to control weight.
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