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Protocol Number:
02-C-0064
- Title:
Collection of Peripheral Blood and/ or Urine From Patients Undergoing Radiation Therapy
- Number:
02-C-0064
- Summary:
Background:
-Research in NCI's Radiation Oncology Branch depends on the availability of blood and urine samples from patients receiving radiation therapy.
Objectives:
-To explore the effects of radiation therapy on gene expression in white blood cells, to measure radiation damage in red blood cells and to examine changes in hormone levels in the blood and urine after radiation therapy.
Eligibility:
-Patients 18 years of age and older who are receiving radiation therapy.
Design:
-Blood and urine samples are collected when participants enter the study.
-Additional samples may be collected at different times during and after treatment. Ideally, samples are obtained before, at the completion of, and 1 month following radiation therapy. Blood samples usually will be collected during routine patient monitoring procedures and will not require an additional needle stick.
-A total of 300 patients will be studied at the NCI in Bethesda, MD, Johns Hopkins University in Baltimore and the University of Pennsylvania in Philadelphia.
- Sponsoring Institute:
-
National Cancer Institute (NCI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
1.) Patients must a candidate for, or currently receiving radiotherapy.
2.) Age greater than or equal to 18 years.
EXCLUSION CRITERIA:
1.) Inability to provide informed consent.
2.) Patients who have unobtainable data regarding previous radiation therapy.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Blood
-
Urine
-
Radiation
-
Non-Therapeutic
-
Cancer
- Recruitment Keyword(s):
-
Radiation
-
Radiation Therapy
- Condition(s):
-
Neoplasms
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Cancer Institute
- Contact(s):
-
Sharon L. Smith, R.N.
National Institutes of Health Building 10 Room B2-3500 10 Center Drive Bethesda, Maryland 20892 Phone: (301) 451-8905 Fax: (301) 480-0647 Electronic Address: smith@mail.nih.gov
- Citation(s):
-
Amundson SA, Bittner M, Chen Y, Trent J, Meltzer P, Fornace AJ Jr. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene. 1999 Jun 17;18(24):3666-72. PMID: 10380890
-
Amundson SA, Do KT, Fornace AJ Jr. Induction of stress genes by low doses of gamma rays. Radiat Res. 1999 Sep;152(3):225-31. PMID: 10453082
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Amundson SA, Do KT, Shahab S, Bittner M, Meltzer P, Trent J, Fornace AJ Jr. Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiat Res. 2000 Sep;154(3):342-6. PMID: 11012342
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Bethesda, Maryland 20892. Last update: 05/05/2009
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