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Protocol Number:
76-N-0021
- Title:
Combined Clinical, Immunological and Virological Assessment of Patients with Multiple Sclerosis (MS)
- Number:
76-N-0021
- Summary:
Multiple sclerosis (MS) is a disease of the nervous system. The exact cause of MS is unknown, but it is believed to be an autoimmune condition. Autoimmune conditions are diseases that cause the body's immune system and natural defenses to attack healthy cells. In the case of MS, the immune system begins attacking myelin, the cells that make up the sheath covering nerves. Without myelin, nerves are unable to transmit signals effectively and symptoms occur.
This study is directed toward a better understanding of the cause of Multiple Sclerosis (MS). Researchers will evaluate patients with a tentative diagnosis of MS or other neurological diseases possibly caused by a immunological reaction. Patients will undergo a series of three MRIs, taken once a month for three months and submit blood samples for immunological studies.
- Sponsoring Institute:
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National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
Diagnosis of possible MS.
Age between 18 and 75.
EXCLUSION CRITERIA:
Clinically significant medical condition other than MS that could cause neurological dysfunction.
Currently enrolled in an experimental study.
Medical contraindication for MRI.
Psychological contraindications for MRI.
Unable to provide informed consent.
- Special Instructions:
Currently Not Provided
- Keywords:
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Immunogenetics
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Tropical Spastic Paraplegia
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Twins
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Epstein-Barr Virus
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HTLV-I
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Vasculitis
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Cerebrospinal Fluid
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Immunity to Viruses
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Multiple Sclerosis
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Magnetic Resonance Imaging
- Recruitment Keyword(s):
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None
- Condition(s):
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Herpesviridae Infection
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HTLV-I Infection
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Multiple Sclerosis
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Tropical Spastic Paraparesis
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Vasculitis
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Neurological Disorders and Stroke
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Immunological aspects of demyelinating diseases
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Brain magnetic imaging in primary Sjogren's syndrome central nervous system disease
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The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 05/05/2009
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