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Developmental Neurotoxicity of Chlorpyrifos: Mechanisms and Consequences

EPA Grant Number: U915425
Title: Developmental Neurotoxicity of Chlorpyrifos: Mechanisms and Consequences
Investigators: Dam, Kristina
Institution: Duke University Medical Center
EPA Project Officer: McClure, Karen
Project Period: September 1, 1998 through August 1, 2001
Project Amount: $45,432
RFA: STAR Graduate Fellowships (1998)
Research Category: Fellowship - Toxicology , Health Effects , Academic Fellowships

Description:

Objective:

The objective of this research project is to examine the adverse effects of chlorpyrifos (CPF) exposure on brain development.

Approach:

For our studies, we use a neonatal rat model because the early postnatal period in rats (postnatal days 1-20) roughly corresponds to the neurodevelopment from the third trimester to the first postnatal year in humans. The treatment paradigm involves repeated CPF exposure during two developmental periods, PN1-4 (examined on PN5 or 10) or PN11-14 (examined PN15 or 20). Doses of CPF are used that are well below the threshold for systemic toxicity, producing no mortality or weight deficits. Likewise, levels of cholinesterase inhibition are well below those that produce acute toxicity.

Supplemental Keywords:

fellowship, pesticide, development, neurotoxicity, chlorpyrifos, CPF, systemic toxicity, cholinesterase inhibition, toxicity. , Toxics, Scientific Discipline, Health, RFA, Susceptibility/Sensitive Population/Genetic Susceptibility, Molecular Biology/Genetics, Toxicology, Biology, Disease & Cumulative Effects, genetic susceptability, Health Risk Assessment, Chemistry, Biochemistry, pesticides, Genetics, insecticides, neurodevelopmental toxicity, developmental toxicity, susceptability to pesticides, chlorpyrifos (Dursban (r)), neurodevelopmental, neurotoxicity

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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