Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.
Zhang XJ,
Huang W,
Yang S,
Sun LD,
Zhang FY,
Zhu QX,
Zhang FR,
Zhang C,
Du WH,
Pu XM,
Li H,
Xiao FL,
Wang ZX,
Cui Y,
Hao F,
Zheng J,
Yang XQ,
Cheng H,
He CD,
Liu XM,
Xu LM,
Zheng HF,
Zhang SM,
Zhang JZ,
Wang HY,
Cheng YL,
Ji BH,
Fang QY,
Li YZ,
Zhou FS,
Han JW,
Quan C,
Chen B,
Liu JL,
Lin D,
Fan L,
Zhang AP,
Liu SX,
Yang CJ,
Wang PG,
Zhou WM,
Lin GS,
Wu WD,
Fan X,
Gao M,
Yang BQ,
Lu WS,
Zhang Z,
Zhu KJ,
Shen SK,
Li M,
Zhang XY,
Cao TT,
Ren W,
Zhang X,
He J,
Tang XF,
Lu S,
Yang JQ,
Zhang L,
Wang DN,
Yuan F,
Yin XY,
Huang HJ,
Wang HF,
Lin XY,
Liu JJ.
Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).
PMID: 19169255 [PubMed - indexed for MEDLINE]