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Literature Searching and Databases

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The list of databases described below provide information on biomedical research, biological science, animal science, veterinary medicine, fish and wildlife research, toxicology and specialized alternative methods.
Many of these databases are available free on the web, while others are fee based and available via vendor, such as DIALOG, OVID, EBSCO, CSA, DataStar, DIMDI, Elsevier Science, ProQuest, Silverplatter, STN and Thompson ISI. Our recommendation is to find a vendor that provides you with one platform to search the most databases that are pertinent to your research, as well as the 3Rs of alternatives - Refinement, Reduction and Replacement. If you have any questions, please contact your library or AWIC.

Alphabetical Browse List: Click on a letter to go directly to the database name starting with that letter.

| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P |
| Q | R | S | T | U | V | W | X | Y | Z |

A

AGRICOLA (AGRICultural OnLine Access) (free online)
Search the USDA, National Agricultural Libraries bibliographic database of agricultural and applied sciences from plants to animals to soil and crops. As it relates to animal use, the database covers animal science, veterinary science, farming practices, housing and husbandry practices, alternative farming systems and other animal agriculture literature.It holds one of the largest collections of veterinary and animal science information. Covers material from the early 1700's to the present.


African Elephant Bibliography/Database (free online)
A searchable database containing over 4100 annotated references on the African elephant of interest to ecology researchers, field staff, resource managers and others.

AltBib (free online)
Searchable bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing from the National Library of Medicine.

Alternative Farming (free online)
Provided by the Animal Welfare Institute. This searchable database contains published and online information for those concerned about factory farming and seeking humane alternatives.

Alternatives in Education Database (free online)
Association of Veterinarians for Animal Rights (AVAR) created database to search for all types of alternatives to the use animals in education, such as CDs, videos, computer simulations, models, and classroom activities for all ages.

AltWeb - Humane Endpoints Database (free online)
This database is designed to help investigators find the earliest "endpoint" that is compatible with the scientific objectives of their research. An endpoint may be defined as "the point at which an experimental animal's pain and/or distress is terminated, minimized, or reduced by taking actions such as killing the animal humanely, terminating a painful procedure, or giving trea tment to relieve pain and/or distress."

AltWeb Pain Management (Anesthesia/Analgesia) Database (free online)This database includes information about anesthesia and analgesia for most commonly used laboratory animals, including: rats, mice, primates, dogs, cats, rabbits, pigs, guinea pigs, birds, sheep, fish, and exotic species. It provides information about available drugs and the side effects of commonly used drugs.

AnimAlt-ZEBET (free online)
The Centre for Documentation and Evaluation of Alternatives to Animal Experiments (ZEBET) is scientific institution that brings about the replacement of legally prescribed animal experiments with alternative test methods, to reduce the number of test animals to the absolutely necessary level and to alleviate the pain and suffering of animals used in experiments. ZEBET is responsible for documenting alternatives to animal experiment, for assessing them, for recommending their use both nationally and internationally. They are also involved in research of their own to develope alternative methods.

Aquatic Sciences and Fisheries Abstracts (ASFA) (fee based)
This database is an International Cooperative Information System which contains an abstracting and indexing service covering the world's literature on the science, technology, management, and conservation of marine, brackish water, and freshwater resources and environments, including their socio-economic and legal aspects. It covers literature from the 1970s to present.

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B

Biodiversity Gateway (free online)
Links to hundreds of key web sites (Multiple agencies involved).

BIOSIS (fee based)
Information from more than 6,000 national and international journals, serials, and proceedings, covering all aspects of thel life science areas, including biomedicine, veterinary medicine, biochemistry, pharmacology, genetics, agriculture, biotechnology, botany, ecology, and environmental sciences. Contains more than 15.6 million total records dating from 1969 to the present.

Biological Resources of the USGS (free online)
Homepage for the Biological Resources Discipline of the USGS providing links to scientific programs, organization, and special features.

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C

CAB (fee based)
This international database covers the applied life sciences, including veterinary medicine, agriculture, forestry, human nutrition, and the environment. It covers topics such as animal science, animal health, animal production, molecular biology, genetics, biotechnology, breeding, taxonomy, physiology and other aspects of pure science relating to organisms of agricultural, veterinary or environmental importance. It contains a vast amount of journals, books, and conference proceeding from 1970 to the present.

Center for Microtechnology (free online)
Expertise in microfabrication technology, microfabricated devices, and miniature/microfabricated instruments.

Chemical Carcinogenesis Research Information System (CCRIS) (free online)
Toxicology database of carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition data.

CITES Species Database
Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) database provides detailed information on the status of species of conservation importance.

COMPENDEX (COMPuterized ENgineering InDEX) (fee based)
A comprehensive bibliographic database covering the worldwide literature in engineering and technology covering such topics as bioengineering, computing, and biomechanics.

Current Contents (fee based)
Current Contents Search is the online version of ISI's popular Current Contents series of publications. Current Contents is a weekly service that reproduces the tables of contents from current issues of leading journals in agriculture, biology & environmental sciences, behavioral sciences, clinical medicine, life sciences, physical sciences, chemical and earth sciences, and engineering, computing and technology.

Current Research Information System (CRIS) (free online)
Search the U.S. Department of Agriculture's (USDA) documentation and reporting system of ongoing and recently completed agricultural, food and nutrition, and forestry research. Projects are conducted or sponsored by USDA research agencies, state agricultural experiment stations, the state land-grant university system, other cooperating state institutions, and participants of USDA-administered grant programs.

Code of Federal Regulations (CFR) (free online)
The Code of Federal Regulations (CFR) is the codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government. It is divided into 50 titles that represent broad areas subject to Federal regulation. Each volume of the CFR is updated once each calendar year and is issued on a quarterly basis.

Computer Retrieval of Information on Scientific Projects (CRISP) (free online)
This a searchable database of federally funded biomedical research projects conducted at universities, hospitals, and other research institutions. biomedical database system containing information on research projects and programs supported by the Department of Health and Human Services and other government agencies. It is a biomedical database system containing information on human diseases, therapeutic interventions, clinical trials and preclinical research from 1986 to the present.

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D

Developmental and Reproductive Toxicology/Environmental Teratology Information Center (DART) (free online)
Database covering teratology and other aspects of developmental and reproductive toxicology.

DIRLINE (Directory of Information Resources Online) (free online)
Database of location and descriptive information about organizations, research resources, projects, and databases concerned with health and biomedicine.

DoD Biomedical Research Database (free online)
This Department of Defense database has been developed from biomedical research, testing or training programs that were funded from 1998-2003. The areas of research, testing and training include, but are not limited to, the following: infectious diseases, biological hazards, toxicology, medical chemical defense, medical biological defense, clinical medicine, clinical surgery, physical protection, training, graduate medical education and instruction.

DoE Information Bridge (free online)
Provides free public access to full-text documents and bibliographic citations of Department of Energy (DOE) research report literature from 1994 to the present. The Information Bridge contains documents and citations in physics, chemistry, materials, biology, environmental sciences, energy technologies, engineering, computer and information science, renewable energy, and other topics of interest related to DOE's mission.

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E

ECOTOX (free online)
The Environmental Protections Agency's database ECOTOXicology provides single chemical toxicity information for aquatic and terrestrial life. It is a useful tool for examining impacts of chemicals on the environment. It primarily contains peer-reviewed literature with pertinent information on the species, chemical, test methods, and abstracted results.

ECVAM SIS (free online)
The European Centre for the Validation of Alternative Methods (ECVAM) is the leading international center for coordinating the validation of alternative methods, providing advice on theoretical and practical aspects of the validation of new tests, and the current state of validation of alternative methods for use in toxicology and the biosciences in general. ECVAM's Scientific Information Service (SIS) is a database on advanced alternative methods in biomedical sciences, providing factual and evaluated information on advanced non-animal test development and validation for toxicology assessments.

Molecular Sequence Database System (free online)
Search multiple databases covering nucleotide sequences, protein sequences, macromolecular structures, and whole genomes.

Environmental Enrichment for Primates (free online)
An annotated database on environmental enrichment and refinement of husbandry for nonhuman primates.

EMBASE (fee based)
This is a comprehensive international database on pharmacological and biomedical literature, similar to Medline. It contains over 18 million records from 1974 to the present and it updated daily.

ERIC (free online)
The Education Resources Information Center contains bibliographic and now some full-text materials free of charge on topics involved in educating people from the elementary to the college level.

EURCA Alternatives Database (free online)
This database contains detailed descriptions of alternatives (focusing on alternatives in education), along with reviews and comments on their use and suitablity, based upon the 3Rs concept.

European Veterinary Dissertations (EVD) Database (free online)
Compiled by Euroscience, in co-operation with the Library of the Faculty of Veterinary Medicine, Utrecht University, The Netherlands and under the auspices of the European Association of Establishments for Veterinary Education (E.A.E.V.E.). Updated monthly.

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F

FDA CBER (free online)
The Food & Drug Administration's Center for Biologics Evaluation and Research (CBER) is responsible for ensuring the safety and efficacy of blood and blood products, vaccines, allergenics, and biological therapeutics. CBER's regulation of biological products has expanded in recent years to include a wide variety of new products such as biotechnology products, somatic cell therapy and gene therapy, and banked human tissues.

FDA Center for Drug Eval & Research (free online)
Provides information for both consumers and firms submitting drug products to FDA.

FDA Center for Food Safety (free online)
CFSAN is responsible for promoting and protecting the public's health by ensuring that the nation's food supply is safe, sanitary, wholesome, and honestly labeled, and that cosmetic products are safe and properly labeled.

The Federal Register (FR) (free online)
Published by the Office of the Federal Register, National Archives and Records Administration (NARA), the Federal Register is the official daily publication for rules, proposed rules, and notices of Federal agencies and organizations, as well as executive orders and other presidential documents.

Federal Research and Development Project Summaries Database (free online)
Descriptions, awards and summaries of federally funded research. Search across databases from the Department of Energy, National Institutes of Health, the National Science Foundation and the United States Department of Agriculture with a single query.

FEDRIP (fee based with free trial offer)
Federal Research In Progress provides access to information about ongoing federally funded projects in the fields of the physical sciences, engineering, and life sciences.

Fish and Fisheries Worldwide (fee based)
A database for researchers of fish and fish culture with citations on all aspects of ichthyology, fisheries, and related aspects of aquaculture. Major topics include culture and propagation, genetics and behavior, natural history, parasites, diseases, habitat managem ent, fish processing/marketing, general research, and fisheries management from 1971 to the present.

FISHBASE (free online)
A global information system covering just about everything on all known fish species. FishBase is a relational database with information for research scientists, fisheries managers, zoologists and many more.

Foreign Doctoral Dissertations Database (free online)
Created by the Center for Research Libraries (CRL) - a consortium of universities, colleges and independent research libraries providing more than 750,000 uncataloged foreign doctoral dissertations, of which approximately 20,000 are included in this database.

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G

GenBank (free online)
Genetic sequence database that is an annotated collection of all publicly available DNA sequences.

GENE-TOX (free online)
Database of genetic toxicology (mutagenicity) test data.

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H

Hazardous Substances Data Bank (HSDB) (free online)
Online database covering the toxicology of potentially hazardous chemicals.

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I

ILAR - Animal Models and Strains Database (free online) ILAR has developed a unique search engine which indexes and searches sites that sell or distribute the animal model or strain of animals used for research.

Integrated Risk Information System (IRIS) (free online) Toxicology database which contains data in support of human health risk assessment with hazard identification and dose-response assessments for over 500 chemicals.

International Pharmaceutical Abstracts (IPA) (fee based)
IPA draws from a global selection of health care journals. Researchers choose to access IPA because it covers international literature in applied pharmacology. Each record is accompanied by an English-language abstract. IPA is used by a variety of researchers in the life sciences because of its inclusion of methods and practices.

InterNICHE (free online)
The InterNICHE Alternatives Loan System is a library of multimedia CD-ROMs, videos, models and mannequins focusing on animal use and alternatives within the biological sciences, as well as in medical and veterinary education covering fields such as anatomy, physiology and surgery. Teachers and students from around the world can borrow items.

Invitroderm (free online)
A database of approximately 360 abstracts about alternatives to skin irritation a nd corrosion testing in animals.

INVITTOX (free online)
This listing of protocols is to present up-to-date technical information on the performance of in vitro techniques and methodologies currently in use and under development with critical assessment comments on their applications, advantages and drawbacks. The information is obtained directly from those scientists already employing such methods.

INSPEC (fee based)
Citations for scientific journals, conference proceedings, books, reports and dissertations covering subjects such as biophysics and medical physics, electrical engineering, computers, information technology and many other aspects of physics from 1969 to the present.

ISI Web of Knowledge (fee based)
This is an integrated, versatile research platform, provides easy access to diversified scholarly information in the sciences, social sciences, and arts and humanities. Users can content from international journals, open access resources, books, patents, proceedings and web sites. Users can simultaneously search multidisciplinary resources such as Web of Science, BIOSIS Previews and CAB Abstracts.

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J

Jackson Laboratory Resources (free online)
The site provides access to a variety of mouse strain and genetic resource databases, including the Mice Database, Mouse Genome Informatics, and International Mouse Strains Resources.


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K

L

LEXIS-NEXIS Statistical Universe for Health Statistics (fee based)
Search over 30,000 statistical tables from over fifty U.S. Department of Health and Services publications. Publications include vital statistics reports, Centers for Disease Control and Prevention Advance Data statistics, and the National Center for Health Statistics documents.

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M

MEDLINE/PubMed (free online)
Database with millions of references, primarily from MEDLINE, to journal articles in life sciences with a concentration on biomedicine.

Molecular Sequence Database System (free online)
Search multiple databases covering nucleotide sequences, protein sequences, macromolecular structures, and whole genomes.

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N

National Ag Safety Database (NASD) (free online)
A collection of information about health, safety and injury prevention in agriculture.

National Biological Information Infrastructure (NBII) (free online)
Links you to divers e biological databases, information products, and analytical tools maintained by government agencies, academic institutions, and non-government organizations (Multiple agencies involved)

National Center for Biotechnology Information (NCBI) (free online)
A national resource for molecular biology information.

National Center for Research Resources (NCRR) (free online)
Ensures access to unique technologies, instrumentation, facilities, animal models , genetic stocks, and biomaterials such as cell lines, tissues, and organs.

National Toxicology Program Studies Database (NTP) (free online)
The NTP is an interagency program consisting of relevant toxicology activities of the National Institutes of Health's National Institute of Environmental Health Sciences (NIH/NIEHS), the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health (CDC/ NIOSH), and the Food and Drug Administration's National Center for Toxicological Research (FDA/NCTR). Currently two databases are available for searching: The Individual Studies Database--search studies by chemical name and The Individual Animal Pathology Database--search for chronic studies collected in the NTP's Toxicology Database Management System and Carcinogenesis Bioassay Data System.

NIH Model Organisms for Biomedical Research (free online)
This web site provides you with information about national and international activities and major resources that are being developed to facilitate biomedical research using the animal models, such as mice, rats, frogs, zebrafish, fruit fly, round worm, amoebae, fungus, yeast and plants.

NORINA (free online)
The Norwegian Inventory of Alternatives is a database with information on approximately 3700 audiovisual aids and other alternatives that can be used in teaching and training from elementary to university level teaching. The site also contains training videos and slides on blood collection techniques.

NSF Publications (free online)
Provide a central clearinghouse for the collection, interpretation, and analysis of data on scientific and technical resources in the United States, and provide a source of information for policy formulation by other Federal agencies.

NTIS Database (free online)
The National Technical Information Service is a central source to locate millions of scientific and technical publications from government agencies.

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O

P

PASCAL (fee based)
An interdisaplinary database created in France, covering subjects such as applied biology, psychology, pharmacology, medicine, toxicology, biotechnology, homeopathy, botany, agriculture, physics, chemistry, information science, mechanical engineering, metallurgy, earth sciences, oceanography and astronomy. Coverage of years from 1973 to the present with b reakdown of languages English 63%, French 12%, Russian 10%, German 8%, and other lanuages 7%.

Poisonous Plant Database (free online)
Provides a list by author of scientific information about the animal and human toxicology of vascular plants of the world.

Porcine Immunology and Nutrition Database (PIN) (free online)
PIN is a searchable, online database that allows users to compare information on 2,600 annotated swine genes and proteins related to nutrition and immunity. It focuses on the linking of gene expression to gene function, identification of related gene pathways and connectivity with other porcine gene databases. Provided by USDA, Agricultural Research Service.

Practical Enrichment Options Database (free online)
This Animal Welfare Institute database disseminates enrichment ideas and practical tips from the "Laboratory Animals Refinement and Enrichment Forum" and from other published information.

PrimateLit Database (free online)
The database provides bibliographic access to the scientific literature on nonhuman primates for the research and educational communities, covering subject areas such as behavior, colony management, ecology, reproduction, field studies, disease models, veterinary science, psychology, physiology, pharmacology, evolution, taxonomy, developmental and molecular biology, genetics and zoogeography.

Primate Info Net (PIN) (free online)
The network is designed to cover the broad field of primatology providing original content and links to resources about nonhuman primates in research, education and conservation. It is maintained by the Wisconsin Primate Research Center (WPRC) Library at the University of Wisconsin-Madison.

PubMed/MEDLINE (free online)
Database with millions of references, primarily from MEDLINE, to journal articles in life sciences with a concentration on biomedicine.

PsycInfo (fee based)
This American Psychological Association (APA) produced resource is database of psychological literature from the 1800s to the present. It contains abstracted citations from journals, conference proceedings, books, reports, dissertation and important internet resources. It is especially useful to those investigators using nonhuman primates in their research.

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Q

R

Registry of Toxic Effects of Chemical Substances (RTECS) (fee based)
A comprehensive database of toxicity information for over 150,000 chemical substances including: prescription and non-prescription drugs, food additives, pesticides, fungicides, herbicides, solvents, diluents, chemical wastes, reaction products of chemical w aste, and substances used in both industrial and household situations. Reports of the toxic effects of each compound are cited. In addition to toxic effects and general toxicology reviews, data on skin and/or eye irritation, mutation, reproductive consequences and tumorigenicity are provided. Federal standards and regulations and NIOSH recommended exposure limits are included. The toxic effects are linked to governmental reports, and published articles from the scientific literature.

Refinement and Environmental Enrichment for All Laboratory Animals (free online)
This database provides reference material on all aspects of refinement of housing and handling conditions and environmental enrichment for ALL animals kept in research, testing and teaching institutions. This database comprises published articles, abstracts, book chapters, books, photos, and videotapes. Entries have been read/screened and annotated by the authors to guarantee their relevance to the topic.

Refinement of Housing and Handling Conditions (free online)
This Animal Welfare Institute database on refinement of housing systems and handling practices and environmental enrichment for animals kept as laboratory animals, covering species such as rodents, rabbits, cats, dogs, ferrets, farm animals, horses, fishes, amphibians and reptiles.

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S

Science and Technology Catalog (free online)
Search a database of Livermore's Web pages pertaining to science and technology..

Science Information System (SIS) (free online)
Database of USGS Biological Resources' research projects. .

The Science Inventory (SI) (free online)
The Science Inventory is a searchable database of EPA science activities and scientific/technical work products. The Science Inventory provides information about current or recently completed activities, providing a snapshot of EPA science being conducted in its research laboratories and centers, program and regional offices, and through grants and other assistance agreements to universities and other institutions.

SCIRUS (free online)
Offers the most comprehensive science-specific search engine on the Internet, designed for scientists and researchers. It provides access to scientific, scholarly, technical and medical data, as well as the latest reports, peer-reviewed articles, patents, pre prints and journals that other search engines miss. In addition to web pages, SCIRUS indexes and searches the following special sources: ScienceDirect (access to full text journals published by Elsevier Science), BioMed Cental (an independent online publishing house providing free access to the peer-reviewed biological and medical research it publishes), as well as other databases such as PubMed, the NASA Technical Reports databases and various other databases. You can select only the databases that you are interested in.

SCOPUS (fee based)
Scopus is the largest abstract and citation database of research literature and quality web sources. Broadest available coverage of scientific, technical, medical and social sciences literature with complete coverage of Medline, along with more life sciences and health related citations and web sites.

SIS ECVAM (free online)
Scientific Information Service on advanced alter native methods to animal experiments in biomedical sciences provides factual and evaluated information on advanced non-animal test development and validation for toxicology assessments coming from a wide range of international information sources.

State Constitutions, Statutes and Related Legislative Information (free online)
This site contains state laws, statutes and related legislation that are governed by each state. You can find statutes by state or by topic area.

STINET Database (free online)
The Defense Technical Information Center (DTIC)'s Scientific and Technical Information Network (STINET) Service helps the DoD research community access scientific and technical information. It provides access to citations of unclassified documents that have been entered into DTIC's Technical Reports Collection, as well as the electronic full-text of many of these documents.

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T

TEXTBASE (free online)
Produced by The Norwegian School of Veterinary Science, Laboratory Animal Unit. Searchable database of approximately 740 current text books within the field of laboratory animal science.

THOMAS (free online)
The Library of Congress created THOMAS database to make federal legislative information freely available to the public. The searchable database includes bills, resolutions, resolution activity in congress, congressional record schedules, calendars, committee information, presidential nominations, treaties and government resources for teachers.

TOXNET (free online)
A collection of databases produced by the National Library of Medicine covering toxicology, hazardous chemicals, environmental health and related areas.

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U

United States Code (free online)
The United States Code is the codification by subject matter of the general and permanent laws of the United States. It is divided by broad subjects into 50 titles and published by the Office of the Law Revision Counsel of the U.S. House of Representatives.

USGS National Biological Information (free online)
The NBII is a publicly available resource that focuses on the agricultural products of modern biotechnology. The highlight is a searchable database which covers genetically engineered crop plants intended for food or feed that have completed all recommended or required reviews for food, feed or planting use in the United States.

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V

VetGate (free online)
VetGate is a free access, searchable database of hand-selected and evaluated Internet resources in Animal Health. New resources are added weekly.

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W

Wildlife and Ecology Studies Worldwide (fee based)
The world�s largest index to literature on wild mammals, birds, reptiles, and amphibians covering all aspects of wildlife and wildlife management from the 1800's to the present.

Wildlife Information Network (WIN) (free online)
Win is a veterinary science based network providing information on the health and management of free-ranging and captive animals and emerging infectious diseases to wildlife professionals and decision-makers worldwide. WIN has created its WildPro electronic encyclopaedia and library of electronic books and documents on the natural history, health and management of captive and free-ranging wild animals.

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X

Y

Z

Zebra Fish Information Network (ZFIN) (fee based)
ZFIN serves as the zebrafish model organism database providing resources for the laboratory use of zebrafish, developing and supporting integrated zebrafish genetics, maintaining the definitive reference data on zebrafish research information, facilitating the use of zebrafish as a model for human biology and serving the needs of the research community.

Zoological Record (fee based)
The world's oldest continuing database covering every field of animal biology from biodiversity and the environment to taxonomy and veterinary sciences. It contains literature from 1864 to the present.


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Last Modified: Nov 12, 2008  
Literature Searching and Databases
    Learn About Searching
    Literature Search Worksheet (PDF|120 KB)
    Sample Searches
    Document Literature Searches
    Animal Use Alternatives Thesaurus
    Guide for Indexers (PDF|58 KB)
    Databases
See Also
    Alternatives and the Animal Welfare Act Brochure (PDF|6 KB)
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