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Endocrine Disruptors Research
Research Projects
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Completed Projects:
Screening and Testing Methods
- A Short-Term in vivo Screening System For Endocrine Disruptors Utilizing Mosquitofishes (Gambusia affinis and G. holbrooki)
- Computational Tools for the Prediction and Classification of Estrogenic Compounds
- Species-Specific Endocrine Disruption: PCB- and PAH-Induced Estrogenic Effects
Human Health Effects
- Dioxin and Steroid Regulation in an Endometriosis Model
- Dioxins, Male Pubertal Development and Testis Function
- Endocrine Disrupting Chemicals and Thyroid Outcomes
- Latent Effects of Gestational Exposure to Heptachlor
- Persistent Organic Pollutants and Endometriosis Risk
- Study of Phthalates in Pregnant Woman and Children
- The Michigan PBB Cohort 20 Years: Endocrine Disruption?
Wildlife and Ecological Effects
- Critical Stages in Avian Development: Estrogen Hazards to Altricial and Precocial Birds
- Field and Laboratory Studies of the Effects of Polychlorinated Biphenyls and Other Persistent Organic Pollutants on Thyroid Function During Avian Development
- Frog Deformities: Role of Endocrine Disruptors During Development
- Endocrine Disruption in Marine Gastropods by Environmental Chemical Mixtures
- Endocrine Disruptors and Host Resistance in Lake Apopka Alligators
- Environmental Endocrine Disruption in Avian Wildlife
- Environmentally-Mediated Endocrine Disruption in Estuarine Crustaceans: A 3-Taxon Multi-Generational Study of Sediment-Association EDC Effects from the Genetic to Population Levels
- Evaluation of Endocrine-Distrupting Chemical Effects Across Multiple Levels of Biological Organization: Integration of Physiology Behavior and Population Dynamics In Fishes
- Exposure and Response of Morelet's Crocodile (Crocodylus moreletii) Populations to Endocrine Disrupting Compounds in Belize, Central America
- Metabolic Androgenization of Invertebrates by Endocrine-Disrupting Chemicals
- Reproductive and endocrine effects of o,p'-DDT, an environmental estrogen, and p,p'-DDE, an antiandrogen, in male and female Atlantic croaker during critical periods of their reproductive life history cycles
- Stages in Sublethal Exposure to EDCs in a Quail Model System
- The Mechanisms and Effects of Endocrine Disruption on Infertility in the Bonnethead Shark on Florida's Gulf Coast
Environmental Exposure
- Developing Rapid Assessment Tools to Evaluate the Biological Effects of Complex and Biologically Active Chemical Mixture
- Development of Receptor- to Population- Level Analytical Tools for Assessing Endocrine Disruptor Exposure in Wastewater-Impacted Estuarine Systems
- Integrated Microfluidic System for Bioluminescent Bioreporting, Separations, Vibrational Spectroscopy, and Microcantilever Transducer of Endocrine Disrupting Chemicals
- Rapid Detection of Trace Endocrine Disrupting Chemicals in Complex Mixtures: A Full- Spectrum Deconvolution Technique with a UV-Transparent Passive Concentrator
- Systems Approach to Assessing Cumulative Exposure to Endocrine Disrupting Chemicals
Early Developmental Outcomes
- An in vivo Model for Detection of Reproductive Effects of Endocrine Disruptors
- Anti-Androgenic Pesticides: Impact on Male Reproduction
- Biochemical and Reproductive Effects of Gestational/Lactational Exposure to PCB's with Respect to Endogenous Sex Steroids and the Proestrogen, Methoxychlor
- Developmental Effects of Dietary Soy Phytoestrogens
- Developmental Exposure to Endocrine Disruptors: Fertility and Gene Expression Profiles
- Effects of an Endocrine Disruptor on Prostate Development and Growth
- Effects of Early Exposure to Xenoestrogens on the Prostate Gland
- Endocrine Disruption in Adolescence
- Endocrine Disruptors and Testis Development
- Endocrine Disruptors: Effects on the Thyroid
- Examination of the Estrogen Response Pathways in a New Vertebrate Model
- Methoxychlor and Environmental "Estrogen" Receptors in ER-Minus Mice
- Models Assessing Direct Effects of Dioxins and Related Compounds on the Ovary
- Xenoestrogen Effects During Premeiotic Stages of Spermatogenesis Development of an In Vitro Test System and Molecular Markers of Action
Ongoing Projects:
Low Dose Effects of EDCs
Development and Characterization of Biological Systems for Studying Low Dose Effects of Endocrine Disrupting Chemicals
Environmental Exposures and Effects
Exposure Measurement Tools for Endocrine Disrupting Chemicals in MixturesFate and Effects of Hormones in Waste from Concentrated Animal Feeding Operations (CAFOs)
- Development of Receptor-to Population-Level Analytical Tools for Assessing Endocrine Disruptor Exposure in Wastewater-Impacted Estuarine Systems
- Developing Rapid Assessment Tools to Evaluate the Biological Effects of Complex and Biologically Active Chemical Mixtures
- Integrated Microfluidic System for Bioluminescent Bioreporting, Separations, Vibrational Spectroscopy, and Microcantilever Transducer Evaluation of Endocrine Disrupting Chemicals
- Rapid Detection of Trace Endocrine Disrupting Chemicals in Complex Mixtures: A Full-Spectrum Deconvolution Technique with a UV-Transparent Passive Concentrator
- Systems Approach to Assessing Cumulative Exposure to Endocrine Disrupting Chemicals
Development of High-Throughput Screening Approaches for Prioritizing Chemicals for the Endocrine Disruptors Screening Program (2003)
- A High Throughput Zebrafish Embryo Gene Expression System for Screening Endocrine Disrupting Chemicals
- Development and Application of a Bioluminescent Yeast-Reporter System for Screening Chemicals for Estrogenic and Androgenic Effects
- Mechanistic Approach to Screening Chemicals and Mixtures for Endocrine Activity Using an Invertebrate Model
- Using a Sensitive Japanese Medaka (Oryzias latipes) Fish Model for Endocrine Disruptors Screening
STAR Awards by RFA:
2006: 2005: 2004: 2003: 2001: 1999: 1997: 1996:
SBIR EDC Awards
Phase I AwardsPhase II Awards
- Development of a Multiplexed Flow Cytometer Receptor Assay
- Development and Preliminary Validation of an Amphibian Lifecycle Test Method for Monitoring Endocrine Disruption
- Development and Preliminary Validation of a Rapid Progestin-Based Endocrine Disruption Screening Assay
- Optical Fiber-Based, Multianalyte Detection System for Simultaneous Screening of Endocrine Disruptors