Bibliographic Citation
| 7,422,724 | |
| Biological preconcentrator | |
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| 09/09/2008 | |
| US patent application 10/214,891 | |
| Manginell, Ronald P. (Albuquerque, NM); Bunker, Bruce C. (Albuquerque, NM); Huber, Dale L. (Albuquerque, NM) | |
| Sandia National Laboratories (SNL-NM), Albuquerque, NM | |
| United States Department of Energy | |
| AC04-94AL85000 | |
| Sandia Corporation (Albuquerque, NM) | |
| A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies. | |
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