Interim Guidance on Environmental Management of Pandemic Influenza Virus

Contents

Summary
Introduction
Management of Environmental Surfaces
Laundry
Routine Solid Wastes and Regulated Medical Wastes
References
Appendix - Public Fact Sheet: Control of Pandemic Flu Virus on Environmental Surfaces in Homes and Public Places

Influenza A and B viruses can persist on both nonporous and porous environmental surfaces for hours to days depending on a variety of human and environmental factors. The secondary spread of infectious virus from environmental reservoirs to susceptible persons is accomplished primarily via hand transfer (i.e., hand contact with contaminated surfaces and then touching mucous membranes of the eyes, nose, and mouth). Proper handwashing or hand hygiene, coupled with respiratory hygiene and cough etiquette is the principal means of interrupting this transfer. Routine cleaning and disinfection strategies used during influenza seasons could be applied to the environmental management of pandemic influenza, if such an event were to occur. Laundry and solid waste management could be performed as usual.

While some assumptions can be made about the behavior of a pandemic virus, the exact characteristics of the virus cannot be known in advance. Influenza viruses are genetically variable, and transmissibility is difficult to predict. As a result, this guidance is subject to change as the unique epidemiologic characteristics of a pandemic influenza virus become known during the course of the pandemic period. Although seasonal influenza A and B viruses are not thought to spread predominantly via airborne routes of transmission, it is possible that a pandemic influenza virus may exhibit properties that would facilitate airborne transmission. Should this occur, environmental management strategies may be revised to incorporate measures to prevent exposure to infectious aerosols.

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Cleaning and Disinfection of Environmental Surfaces

Cleaning and disinfection can reduce the numbers of viruses present on environmental surfaces, which can help to minimize hand transfer of virus (10). Influenza viruses are enveloped, lipid-containing viruses, and as such are readily sensitive to a wide variety of chemical disinfectants (Figure 1) (11). While historically there has been a clear distinction between pandemic strains of influenza viruses and seasonal influenza viruses based on antigenic specificity, there is no new evidence to suggest that pandemic influenza viruses are biophysically or biochemically different than seasonal influenza virus. Although pandemic influenza viruses may cause severe disease, influenza viruses are among the least resistant microorganisms to chemical disinfection. Therefore, routine cleaning and disinfection strategies used during influenza seasons could be applied for the environmental management of pandemic influenza.

Figure 1. Relative Resistance Levels of Microorganisms to Chemical Disinfection (High to Low Levels in Descending Order)

Bacterial Spores
↓
Mycobacteria
↓
Non-lipid or small viruses
↓
Fungi
↓
Vegetative bacteria
↓
Lipid or medium-sized viruses
(influenza viruses)

Cleaning with soap or detergent in water is the first step in surface treatment. Cleaning will remove soil and organic matter that would otherwise reduce the effectiveness of the disinfection step that follows. There is no indication for cleaning procedures that differ from what is done routinely. Any commercially available soap or detergent can be used. Water can be cold or warm, or as recommended on the label of the cleaning product used (if a specific temperature is listed).

Influenza viruses can be inactivated by many low- or intermediate level disinfectants containing any of the following ingredients (12):

• chlorine or hypochlorite
• aldehydes
• quaternary ammonium compounds [quats]
• phenolics
• alcohols
• peroxygen compounds

Use of disinfectants registered by the U.S. Environmental Protection Agency (EPA) is recommended whenever these are available. Lists of all registered disinfectants can be found at http://www.epa.gov/oppad001/chemregindex.htm. Many, if not all, of these products indicate potency for several target pathogens on the label. There are approximately 400 registered disinfectants with human influenza A and/or B listed on the product label, and all will inactivate influenza viruses when used according to manufacturer instructions.

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• Environmental Services staff should use appropriate personal protective equipment (PPE) (i.e., household gloves) as needed when preparing disinfectant and cleaning solutions and when applying these solutions by hand to wipes and/or surfaces.
• Clean and disinfect surfaces that are touched routinely by hand (e.g., doorknobs, bed rails, bedside- and over-bed tables, bathroom surfaces, safety/pull-up bars, television controls, call buttons) on a more frequent schedule than that used for large housekeeping surfaces.
• Follow manufacturer instructions for proper use of disinfectants, especially with regards to the proper concentration of product and the time the product should be in contact with the surface being disinfected.
• Consult medical equipment instructions for appropriate methods of cleaning and disinfection for these items, and consider using barrier coverings for equipment that may be hard to clean or has accessible electronic components.
• Clean large housekeeping surfaces (e.g., floors) in patient-care areas with detergent/disinfectants in accordance with manufacturer instructions on a regular basis as per facility policy (i.e., at least daily and terminally cleaned at patient discharge).
• Avoid large-surface cleaning methods that produce mists or aerosols or disperse dust in patient-care areas (e.g., use wet dusting techniques, wipe application of cleaning and/or disinfectant solutions).
• Detergent and water are adequate for cleaning surfaces in nonpatient-care areas (e.g., administrative offices).
• Follow facility procedures to ensure the cleanliness of cleaning and/or disinfectant solutions, rinse water, mop heads, and cloths (e.g., separate buckets for solutions and rinse water, frequent exchanges of solutions, replacing soiled mops heads and cloths with clean items, using microfiber mopping methods).
• Avoid placing influenza patients in rooms with carpeting if possible; use vacuums equipped with HEPA filtration when vacuuming carpets in patient-care areas.
• Educate patients, staff, and visitors about the importance of handwashing and hand hygiene, emphasizing “hand awareness” (i.e., touching nose, mouth, or eyes after touching a potentially contaminated surface or object) (15, 16).

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(ii) Cleaning and Surface Disinfection in Homes, Schools, and Businesses:
The adherence to good personal hygiene, proper hand hygiene, respiratory hygiene, and cough etiquette is especially important for preventing the spread of influenza in non-healthcare settings in the community (16). Schools may dismiss classes, and businesses may consider implementing social distancing as an influenza control strategy early on during a moderate or severe influenza pandemic (17, 18). While school remains in session and when businesses reduce onsite staffing, environmental infection control for non-healthcare settings focuses on regular cleaning for most surfaces and targeted use of disinfection for surfaces touched frequently by hand:

• Keep housekeeping surfaces and countertops clean of visible soil by cleaning with detergents and water or proprietary cleaners, followed by rinsing with water. Repeated application of disinfectants to table and desktop surfaces is unnecessary. Frequent use of room air deodorizers to disinfect the air is not recommended.
• Follow label instructions carefully when using disinfectants and cleaners, noting any hazard advisories and indications for using personal protective items (such as household gloves).  Do not mix disinfectants and cleaners unless the labels indicate it is safe to do so.  Combining certain products (such as chlorine bleach and ammonia cleaners) can be harmful, resulting in serious injury or death. 
• Clean and disinfect bathroom surfaces on a regular basis using EPA-registered detergent/disinfectants. Alternatively, clean surfaces first with detergent and water and then disinfect with an EPA-registered disinfectant in accordance with manufacturer instructions. (Note: Disinfectant products available in grocery stores or hardware stores are all EPA-registered.)
• If EPA-registered disinfectants are not available, use a dilute solution (1:100 volume/volume, approximately 600 parts per million [ppm]) of household chlorine bleach (sodium hypochlorite) to disinfect bathroom surfaces. To prepare this solution, add ¼ cup of bleach to a gallon of clean water, or 1 tablespoon of bleach to a quart of clean water. Apply to a cleaned surface, preferably with a cloth moistened with the bleach solution, and allow the surface to remain wet for minimally 3 – 5 minutes (13).
• Clean and disinfect commonly touched surfaces in the home with a detergent/disinfectant in accordance with label instructions (e.g., microwaves, refrigerator door handles, door handles).
• Wipe frequently touched electronic items (e.g., remote controls, hand-held gaming devices) with hand-sanitizer cloths.
• Carry hand-sanitizer cloths in cars to use on hands and surfaces in cars.

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• Handle soiled clothing and linens during collection with a minimum amount of agitation and fluffing;
• Healthcare workers and laundry personnel should follow established facility safety procedures (minimum recommendation is for glove use) when handling soiled linens.
• Handwashing or hand hygiene should be done in the home after sorting laundry and adding the clothing and linens to the washer.
• Use detergents, laundry additives, and appropriate water temperature as per routine laundry procedures. Follow manufacturer instructions for detergent and bleach use.
• Use a temperature setting for drying clothes and linens appropriate for the fabrics in the load. Line- or air-drying can be used to dry items when machine drying is not indicated.
• Clean your hands before removing clean laundry from the washer or dryer, especially if you have coughed or sneezed onto your hands.
  

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• Healthcare Facilities:
  • Use Standard Precautions when working with solid waste that may be contaminated with influenza virus outside of patient isolation areas.
  • Use PPE as is currently required by your state (e.g., gloves) when handling open waste containers.
  • No changes in waste containment need be made during periods of influenza activity (e.g., single bag lining for routine clinic wastes, appropriate labeled containment for regulated medical wastes).
  • Current medical waste treatment procedures can be used to treat regulated medical waste in accordance with state and federal regulations.
  • Treated medical waste can be safely deposited in municipal solid waste landfills as per normal procedures.
• Homes, Schools, and Businesses:
  • Disposable tissues used to contain coughs, sneezes, or nasal discharges can be tossed in waste receptacles; no special precautions are required.
  • Handwashing or hand hygiene should be done after emptying these waste containers.
  • Barring specific state routine solid waste or medical waste regulations to the contrary, these wastes are considered routine solid wastes in the community that can be sent to municipal solid waste landfills without treatment.

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1.  Bean B, Moore BM, Sterner F, Peterson LR, Gerding DN, Balfour HH Jr.  Survival of influenza viruses on environmental surfaces.  J Infect Dis 1982; 146: 47-51.

2.  Barker J, Stevens D, Bloomfield SF.  Spread and prevention of some common viral infections in community facilities and domestic homes.  J Appl Microbiol 2001; 91: 7-21.

3.  Edward DG.  Resistance of influenza virus to drying and its demonstration on dust.  Lancet 1941; 241: 664-6. 

4.  Parker ER, MacNeal WJ.  Persistence on influenza virus on the human hand.  J Lab Clin Med 1944; 29: 121-6.  

5.   Boone SA, Gerba CP.  The occurrence of influenza A virus on household and day care center fomites.  J Infect Dis 2005; 51: 103-9.

6.  Hall CB, Douglas RG Jr, Geiman JM.  Possible transmission by fomites of respiratory syncytial virus.  J Infect Dis 1980; 141: 98-102.

7.  Brady MT, Evans J, Cuartas J.  Survival and disinfection of parainfluenza viruses on environmental surfaces.  Am J Infect Control 1990; 18: 18-23.

8.  Ansari SA, Stringthorpe VS, Sattar SA, Rivard S, Rahman M.  Potential role of hands in the spread of respiratory viral infections: Studies with human parainfluenza virus 3 and rhinovirus 14.  J Clin Microbiol 1991; 29: 2115-9.

9.  von Rheinbaben F, Schünemann S, Groß T, Wolff MH.  Transmission of viruses via contact in a household setting: Experiments using bacteriophage ΦX174 as a model virus.  J Hosp Infect 2000; 46: 61-6.

10.  Sattar SA, Jacobsen H, Springthorpe VS, Cusack TM, Rubino JR.  Chemical disinfection to interrupt transfer of rhinovirus type 14 from environmental surfaces to hands.  Appl Environ Microbiol 1993; 59: 1579-85.

11.  Favero MF, Bond WW.  Chemical disinfection of medical and surgical materials.  In: Disinfection, Sterilization, and Preservation, 4^th Edition, SS Block (ed.).  Lea & Febiger; Philadelphia, PA; 1991: p. 617-41.

12.  Prince HN, Prince DL.  Principles of viral control and transmission.  In: Disinfection, Sterilization, and Preservation, 5^th Edition, SS Block (ed.).  Lippincott, Williams & Wilkins; Philadelphia, PA; 2001:  p. 543-71.    

13.  Centers for Disease Control and Prevention.  Guidelines for environmental infection control in health-care facilities: Recommendations of CDC and the Healthcare Infection Control Advisory Committee (HICPAC).  MMWR 2003; 52 (No. RR-10): 1-48.  (See also the full text version of this guideline at http://www.cdc.gov/ncidod/dhqp/gl_environinfection.html ).

14.  World Health Organization.  Avian influenza, including influenza A (H5N1), in humans: WHO interim infection control guideline for health care facilities (amended 24 April 2006).  Accessed 13 September 2006 at:  http://www.who.int/csr/disease/avian_influenza/guidelines/infectioncontrol1/en/index.html

15.  Centers for Disease Control and Prevention.  Guideline for hand hygiene in health-care settings: Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force.  MMWR 2002; 51 (RR-16): 1-45.

16.  Centers for Disease Control and Prevention.  Stopping the spread of germs at home, work, and school.  Accessed 5 October 2006 at:  http://www.cdc.gov/flu/protect/stopgerms.htm

17.  World Health Organization Writing Group.  Nonpharmaceutical interventions for pandemic influenza national and community measures.  Emerg Infect Dis 2006; 12: 88-94.

 18.  Centers for Disease Control and Prevention.  Interim pre-pandemic planning guidance: Community strategy for pandemic influenza mitigation in the United States – Early, targeted, layered use of nonpharmaceutical interventions.  Accessed 29 May 2007 at:  http://www.pandemicflu.gov/plan/community/community_mitigation.pdf

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Control of Pandemic Flu Virus on Environmental Surfaces in Homes and Public Places

This fact sheet explains how cleaning and disinfecting surfaces in homes and public places (like schools) can help to prevent the spread of pandemic influenza (flu). This fact sheet will be updated as needed.

How Flu Viruses Spread

• A flu pandemic is an outbreak of illness caused by a new flu virus that spreads around the world. Because the virus is new to people, nearly everyone will be at risk of getting it. 
• The main way that illnesses like colds and flu are spread is from person to person by coughs and sneezes. This can happen when droplets from a cough or sneeze of an infected person move through the air and make contact with the mouth or nose of people nearby.
• Droplets from an infected person can also make contact with environmental surfaces (like the tops of tables). The virus can then be spread from those surfaces if a person touches the droplets and then touches his or her own eyes, mouth, or nose before washing his or her hands. 
• The virus also can be spread when an infected person coughs or sneezes into his or her hands and then touches a surface (like a phone, remote control, or toy) before washing his or her hands. Another person could become sick if he or she touches that surface and then touches his or her own eyes, mouth, or nose before washing. Flu viruses and other germs can live 2 hours or longer on hard environmental surfaces like tables, doorknobs, and desks. Surfaces are likely to be touched much more often than they can be cleaned and disinfected. Thus, it is important to wash your hands often, keep your hands away from your face, and keep such surfaces clean to help prevent the spread of germs.

How to Stop the Spread of Pandemic Flu Virus from Environmental Surfaces

 Use good hygiene practices

• Cover your mouth and nose with a tissue when you cough or sneeze; put the used tissue in a waste basket and clean your hands.
• Cover your mouth and nose with your upper sleeve (not your hands) if you do not have a tissue and need to cough or sneeze.
• Clean your hands as soon as possible after coughing, sneezing, or blowing your nose.
  • Use soap and water and wash your hands for 15 - 20 seconds; or
  • Use alcohol-based hand wipes or alcohol-based (60-95% alcohol) gel hand sanitizers; rub these on the hands until the liquid or gel dries.
• Clean your hands often when you or others are sick, especially if you touch your mouth, nose, and eyes.
• Always clean your hands before eating.
• Carry alcohol-based hand wipes or alcohol-based (60-95% alcohol) hand-sanitizing gels with you to clean your hands when you are out in public. 
• Teach your children to use these hygiene practices because germs are often spread at school. 

Clean and disinfect hard surfaces and items in homes and schools

• Follow label instructions carefully when using disinfectants and cleaners.
  • Pay attention to any hazard warnings and instructions on the labels for using personal protective items (such as household gloves).
  • Do not mix disinfectants and cleaners unless the labels indicate it is safe to do so.  Combining certain products (such as chlorine bleach and ammonia cleaners) can be harmful, resulting in serious injury or death. 
• Keep hard surfaces like kitchen countertops, tabletops, desktops, and bathroom surfaces clean and disinfected. 
  • Clean the surface with a commercial product that is both a detergent (cleans) and a disinfectant (kills germs). These products can be used when surfaces are not visibly dirty.
  • Another way to do this is to wash the surface with a general household cleaner (soap or detergent), rinse with water, and follow with a disinfectant. This method should be used for visibly dirty surfaces.
  • Use disinfectants on surfaces that are touched often. Clean the surface as explained above before using disinfectants.
    • If disinfectants are not available, use a chlorine bleach solution made by adding 1 tablespoon of bleach to a quart (4 cups) of water; use a cloth to apply this to surfaces and let stand for 3 – 5 minutes before rinsing with clean water. (For a larger supply of disinfectant, add ¼ cup of bleach to a gallon [16 cups] of water.)
    • Wear gloves to protect your hands when working with strong bleach solutions.
• Keep surfaces touched by more than one person clean and disinfected. Examples of these surfaces include doorknobs, refrigerator door handles, and microwaves.
  • Clean with a combination detergent and disinfectant product.  Or use a cleaner first, rinse the surface thoroughly, and then follow with a disinfectant.
  • Use sanitizer cloths to wipe electronic items that are touched often, such as phones, computers, remote controls, and hand-held games.
  • Use sanitizer cloths to wipe car door handles, the steering wheel, and the gear shift.

Use recommended laundry practices

• Gently gather soiled clothing, bedding, and linens without creating a lot of motion or fluffing; for example, do not shake sheets when removing them from the bed.
• Clean your hands after handling soiled laundry items.
• Use washing machine cycles, detergents, and laundry additives (like softener) as you normally do; follow label instructions for detergents and additives.
• Dry the cleaned laundry items as you normally do, selecting the dryer temperature for the types of fabrics in the load.  Line- or air-drying can be used to dry items when machine drying is not indicated.
• Clean your hands before removing clean laundry from the washer or dryer, especially if you have coughed or sneezed on your hands.

Use recommended waste disposal practices

• Toss tissues into waste baskets after they have been used for coughs, sneezes, and blowing your nose.
• Place waste baskets where they are easy to use.
• Avoid touching used tissues and other waste when emptying waste baskets.
• Clean your hands after emptying waste baskets.

Additional Information

Disinfectant products (sanitizer cloths and liquid disinfectants) available from grocery stores, hardware stores, and commercial cleaning product suppliers have been registered with the U.S. Environmental Protection Agency (EPA). Always follow label instructions carefully when using these products. For more information about EPA-registered disinfectants, visit www.epa.gov/oppad001/chemregindex.htm. For more information about cleaning and disinfection of surfaces to protect against pandemic influenza virus, consult “Interim Guidance on Environmental of Pandemic Influenza Virus.” To learn more about pandemic influenza, visit www.pandemicflu.gov.