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2009
March
March 2, 2009: Low Levels of Vitamin B12 May Increase Risk for Neural Tube Defects
Children born to women who have low blood levels of vitamin B12 shortly before and after conception may have an increased risk of a neural tube defect, according to an analysis by researchers at the National Institutes of Health, Trinity College Dublin, and the Health Research Board of Ireland. Women with the lowest B12 levels had 5 times the risk of having a child with a neural tube defect compared to women with the highest B12 levels.
February
February 18, 2009: Could Genetics Improve Warfarin Dosing?
In a large-scale study and an upcoming clinical trial, scientists supported by the National Institutes of Health address one of the trickiest issues in prescribing medicine — how to quickly optimize each patient's dosage of the common blood-thinning drug warfarin. Using information from thousands of genetically and geographically diverse patients, an international team of researchers, funded in part by the National Human Genome Research Institute, has developed a way to use genetic information from patients that could help doctors better determine optimal warfarin doses. The results of the analysis are published in an article titled "Warfarin Dosing Using Clinical and Pharmacogenetic Data" in the Feb. 19 issue of The New England Journal of Medicine.
February 2, 2009: New Findings Raise Questions About Process Used to Identify Experimental Drug for Rare Genetic Diseases
A study by National Institutes of Health (NIH) researchers reveals surprising new insights into the process used to initially identify an experimental drug now being tested in people with cystic fibrosis and muscular dystrophy. Researchers emphasized that the clinical implications of their findings are unclear, but said the results suggest more work may be needed to make sure the screening process to select promising agents was not flawed by its effects on a firefly enzyme used as a marker.
Last Updated: March 2, 2009
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