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FOX gene family

Reviewed February 2008

What are the FOX genes?

The FOX gene family provides instructions for making proteins that play a critical role in the formation of many organs and tissues before birth. These proteins are transcription factors, which means that they attach (bind) to specific regions of DNA and help control the activity of many other genes. Members of the FOX family are involved in many aspects of embryonic development. FOX proteins regulate certain gene activities in the eyes, lungs, brain, cardiovascular system, digestion system, immune system, and cell division cycle. Mutations in some FOX genes can lead to tumor development.

The FOX genes are named with a letter and a number in order to identify which FOX gene subfamily they belong to. The subfamilies are designated by a letter (A through R) and the individual genes in these subfamilies are further designated by a number (e.g. FOXD4).

Which genes are included in the FOX gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the FOX familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference provides additional information about these members of the FOX gene family: FOXC2, FOXL2, and FOXP3.

What conditions are related to genes in the FOX gene family?

Where can I find additional information about the FOX gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the FOX (Forkhead box genes) gene family?

cardiovascular ; cell ; cell division ; cell division cycle ; digestion ; DNA ; embryonic ; gene ; immune system ; motif ; mutation ; protein ; tissue ; transcription ; transcription factor ; tumor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

References (7 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: February 2008
Published: January 30, 2009