The FOX gene family provides instructions for making proteins that play a critical role in the formation of many organs and tissues before birth. These proteins are transcription factors, which means that they attach (bind) to specific regions of DNA and help control the activity of many other genes. Members of the FOX family are involved in many aspects of embryonic development. FOX proteins regulate certain gene activities in the eyes, lungs, brain, cardiovascular system, digestion system, immune system, and cell division cycle. Mutations in some FOX genes can lead to tumor development.
The FOX genes are named with a letter and a number in order to identify which FOX gene subfamily they belong to. The subfamilies are designated by a letter (A through R) and the individual genes in these subfamilies are further designated by a number (e.g. FOXD4).
The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the FOX family.
Genetics Home Reference provides additional information about these members of the FOX gene family: FOXC2, FOXL2, and FOXP3.
Genetics Home Reference includes these conditions related to genes in the FOX gene family:
You may find the following resources about the FOX gene family helpful.
The Handbook provides basic information about genetics in clear language.
The resources on this site should not be used as a substitute for
professional medical care or advice. Users seeking information about
a personal genetic disease, syndrome, or condition should consult with a qualified
See How can I find a genetics professional in my area? in the Handbook.