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COLPG gene family

Reviewed February 2008

What are the COLPG genes?

The COLPG genes provide instructions for making the protein component of large molecules called collagen proteoglycans. A proteoglycan is a molecule that is made up of a core protein attached to one or more sugar molecules called glycosaminoglycan (GAG) chains. The COLPG gene family is a subset of a larger gene family known as the proteoglycan superfamily.

The many different types of proteoglycans are classified according to their core protein. The core protein produced by members of the COLPG gene family is collagen. Collagens are a family of proteins that strengthen and support connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Collagen proteoglycans are major components of the extracellular matrix, which is an intricate lattice of proteins and other molecules that forms in the spaces between cells. The collagen proteoglycans bind to a variety of other proteins in the extracellular matrix, including other forms of collagen.

Which genes are included in the COLPG gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the COLPG familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference provides additional information about these members of the COLPG gene family: COL9A1, COL9A2, and COL9A3.

What conditions are related to genes in the COLPG gene family?

Genetics Home Reference includes these conditions related to genes in the COLPG gene family:

Where can I find additional information about the COLPG gene family?

You may find the following resources about the COLPG gene family helpful.

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the COLPG (collagen proteoglycans) gene family?

cartilage ; cell ; collagen ; connective tissue ; extracellular ; extracellular matrix ; gene ; ligament ; molecule ; protein ; proteoglycan ; tendon ; tissue

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

References (3 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: February 2008
Published: January 30, 2009