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Channels & disorders Anions ATPase Calcium Chloride Concepts Cyclic nucleotide-gated Gap junctions Long QT Syndromes Magnesium Mitochondrial solute carriers Na+, K+, Cl- Co-transporters Potassium HCN KCN K+/H+ ATPase Proton-gated Sodium Na+/H+ exchangers Non-voltage-gated Voltage-gated Toxins Transient receptor potential Channel binding proteins Transmitters/Receptors Acetylcholine ATP Capsaicin Catecholamines Dopamine Glutamine Glycine Purines Diagrams |
CHANNEL TYPES: General9
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Principles Disorders |
Figure Principles: Na+ channels Exchangers Non-voltage-gated Voltage-gated Na+ channel disorders |
Ca++ channel disorders Ca++ channel: Figures Types Voltage-gated Ca++ channels Classes Principles Ca++ sensors Intracellular activation: Ryanodine + Ligand gated Other Ca++ channels |
Figure K+ channel disorders Principles Structure Functions Subunits Types |
Gap junction |
Ion channel | Binding protein | Mechanism & Effect |
---|---|---|
K+ channel, Voltage-gated Shaker type NMDA receptor NR2 subunit |
Chapsyns*: PSD-95
;
SAP97 ; Chapsyn-110 ; Sap102 ; Dlg |
Binding via PDZ** domains 1st & 2nd on PSD-95 Post-synaptic densities in CNS |
NMDA receptor
NR1 subunit |
α-actinin |
Actin binding protein Concentrated in dendritic spines |
Glycine receptor (GlyR) | Gephyrin |
Binds to β intracellular loop of GlyR & tubulin |
AChR: Nicotinic | Rapsyn/43K | Neuromuscular junction localization |
Na+ channel Voltage-gated |
Ankyrin G | Node of Ranvier localization |
AMPA receptor GluR2 subunit |
Glutamate receptor interacting protein (GRIP) |
Binding via PDZ domain Couples receptor to cytoskeletal & signaling molecules |
Glutamate receptor Metabotropic Subunits: mGluR1a & mGluR5 |
Homer | Binding via PDZ-like domain Expression é by synaptic activity |
Marine toxins Ciguatoxin Conotoxins Palytoxin (Clupeotoxism) Tetrodotoxin Shell fish Saxitoxin: Paralytic Domoic acid: Encephalopathic Brevetoxins: Neurotoxic Diarrheic Other Lidocaine Potassium channel |
Epidemiology Toxicity Clinical Laboratory |
From NCI Palytoxin
|
Tetrodotoxin |
From FDA |