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WNT gene family

Reviewed February 2008

What are the WNT genes?

Researchers have identified 19 genes in the WNT gene family. These genes provide instructions for making similar proteins that participate in chemical signaling pathways in the body. Some WNT proteins are specific to certain cells and tissues.

WNT proteins are ligands, which means they can attach (bind) to other proteins called receptors. A ligand and its receptor fit together like a key in a lock. WNT proteins bind with receptors called Frizzled proteins on the surface of cells. This binding triggers a multi-step process within the cell that allows a molecule called beta-catenin to move into the nucleus, where it activates certain genes. The association of WNT proteins with Frizzled receptors, and the subsequent effects on beta-catenin, are known as the canonical WNT signaling pathway. This pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation).

WNT signaling is known to be involved in many aspects of embryonic development. The WNT signaling pathway controls the activity of genes needed at specific times during development, and it regulates the interactions between cells as organs and tissues are forming. Mutations that disrupt the functions of WNT genes during embryonic development have been found to cause birth defects. In adult tissues, WNT signaling plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. Studies suggest that abnormal WNT signaling is associated with many human diseases, including cancer and degenerative diseases such as osteoarthritis.

Although most studies have focused on the canonical WNT signaling pathway, WNT proteins also have other functions. For example, noncanonical WNT signaling is involved in determining the position of various components within cells (cell polarity), regulating the migration of nerve cells, and directing the development of the heart during the earliest stages of embryonic development. Noncanonical WNT signaling is not well understood, however.

Which gene is included in the WNT gene family?

The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the WNT familyThis link leads to a site outside Genetics Home Reference..

Genetics Home Reference provides additional information about this member of the WNT gene family: WNT3.

What conditions are related to genes in the WNT gene family?

Genetics Home Reference includes these conditions related to genes in the WNT gene family:

Where can I find additional information about the WNT gene family?

Where can I find general information about genes and gene families?

The Handbook provides basic information about genetics in clear language.

What glossary definitions help with understanding the WNT (wingless-type MMTV integration site family) gene family?

cancer ; cell ; degenerative ; differentiation ; embryonic ; gene ; ligand ; molecule ; mutation ; nerve cell ; nucleus ; proliferation ; protein ; receptor ; stage ; stem cells ; tissue

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

References (8 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: February 2008
Published: January 30, 2009