Reviewed February 2008
What is the official name of the DRD3 gene?
The official name of this gene is “dopamine receptor D3.”
DRD3 is the gene's official symbol. The DRD3 gene is also known by other names, listed below.
What is the normal function of the DRD3 gene?
The DRD3 gene provides instructions for making a protein called dopamine receptor D3, which is found in the brain. This protein responds to the chemical messenger (neurotransmitter) dopamine to trigger signals within the nervous system, including signals involved in producing physical movement.
How are changes in the DRD3 gene related to health conditions?
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essential tremor - associated with the DRD3 gene
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Some studies have found the DRD3 gene to be associated with essential tremor. A DRD3 variant seen in some families affected by this disorder results in a dopamine receptor D3 protein in which the protein building block (amino acid) serine at position 9 is replaced with the amino acid glycine (written as Ser9Gly or S9G). This variant binds more strongly to dopamine, resulting in a stronger response to the neurotransmitter and possibly causing the involuntary shaking seen in essential tremor.
Where is the DRD3 gene located?
Cytogenetic Location: 3q13.3
Molecular Location on chromosome 3: base pairs 115,330,246 to 115,380,588
The DRD3 gene is located on the long (q) arm of chromosome 3 at position 13.3.
More precisely, the DRD3 gene is located from base pair 115,330,246 to base pair 115,380,588 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about DRD3?
You may also be interested in these resources, which are designed for genetics professionals and researchers.
- PubMed
- Recent literature
- OMIM - Genetic disorder catalog
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What other names do people use for the DRD3 gene or gene products?
- D3DR
- DRD3_HUMAN
- ETM1
- FET1
- MGC149204
- MGC149205
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding DRD3?
acids ;
amino acid ;
dopamine ;
gene ;
glycine ;
involuntary ;
nervous system ;
neurotransmitters ;
protein ;
receptor ;
serine ;
tremor
You may find definitions for these and many other terms in the Genetics Home Reference
Glossary.
The resources on this site should not be used as a substitute for
professional medical care or advice. Users seeking information about
a personal genetic disease, syndrome, or condition should consult with a qualified
healthcare professional.
See How can I find a genetics professional in my area? in the Handbook.
