NLM Standards Related Activities (Slide 1)

Vivian A Auld
Senior Specialist for Health Data Standards
National Library of Medicine

HL7 Working Group Meeting
San Antonio, TX
January 14, 2008

Presidential Executive Order.April 27,2004 (Slide 2)

With goal of ubiquitous electronic health records and a national health information infrastructure in 10 years:

Established new National Health Information Technology Coordinator in HHS with responsibility for strategic plan to:

"(i) Advance the development, adoption, and implementation of health care information technology standards nationally through collaboration among public and private interests, and consistent with current efforts to set health information technology standards for use by the Federal Government;

(ii) ... ."

The URL is www.whitehouse.gov/news/releases/2004/04/20040427-4.html

HHS Health IT Strategic Framework. July 21, 2004 (Slide 3)

"A key component of a national health information network is the development of technically sound and robustly specified interoperability standards for diffusion into practice."

HHS Health IT (Slide 4)

The URL is www.hhs.gov/healthit

Strategy for Achieving U.S. Health Data Standards (Slide 5)

• Establish mechanism for designating U.S. Standards
• Pick best available as starting point
• Support development, maintenance, and low/no cost distribution
  • NLM leadership and ongoing commitment
• Coordinate development of selected standards to achieve non-overlapping, interlocking set
• Broaden participation in standards development
• Promote use and improvement

Use Cases (Slide 6)

The URL is www.hhs.gov/healthit/usecases

Healthcare Information Technology Standards Panel (HITSP) (Slide 7)

The URL is www.ansi.org/hitsp/

NLM's Role (Slide 8)

NLM-led Support for Development and Maintenance (Slide 9)

• 1999 - LOINC (lab tests/instrument observations) - contract support
• 2002 - RxNorm (clinical drugs) - direct development
• 2003 - SNOMED CT contract & license for U.S-wide use (as distributed by NLM in UMLS)

Unified Medical Language System UMLS (Slide 10)

The URL is umlsinfo.nlm.nih.gov

Letter from HHS Secretary to NCVHS Sept. 2004 (Slide 11)

"As you requested ..., NLM to serve as the central coordinating body within HHS for PMRI [Patient Medical Record Information] terminologies. ... several ... mapping recommendations currently are being implemented by the NLM."

Coordination means: (Slide 12)

• Uniform distribution of designated standard vocabularies through the UMLS Metathesaurus
• Reducing peripheral overlap and establishing explicit relationships between standard clinical vocabularies (e.g., SNOMED, LOINC, RxNorm)
• Aligning standard clinical vocabularies with standard record and message formats
• Mapping between standard clinical vocabularies and administrative code sets and/or other important vocabularies

NLM Long Range Plan for 2006-2016 (Slide 13)

3.2 Promote Development of "Next Generation" Electronic Health Records

• Continue and enhance current standards efforts:
  • Develop, support, license, disseminate vocabulary standards via UMLS
  • Develop subsets, mappings, and other tools in collaboration with actual clinical systems
  • Contribute to health information technology policy development
• Expand research and development to define and develop more advanced electronic health records

Health IT at NLM (Slide 14)

The URL is www.nlm.nih.gov/healthit.html

Specific Projects (Slide 15)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

2007AA UMLS Metathesaurus (Jan 2007) (Slide 16)

• ~1,373,000 concepts
• ~4,967,000 "terms" (Eye, Eyes, eye = 1)
• ~5,546,000 unique "strings" (Eye, Eyes, eye = 3)
• ~6,773,000 "atoms" or source vocabulary strings (Eye [from MeSH], Eye [from SNOMED CT] = 2)
• 139 source vocabularies (121 "families")
• 17 different languages

• Multi-purpose - MUST be customized for any specific purpose

UMLS^® - Moved from a Research Project to a Production System (Slide 17)

• Included:
  • Transitioned from research branch (Lister Hill Center) to production branch (Office of Computer and Communications Systems and Library Operations)
  • Migrated to new computer hardware and software
  • Adding new staff to support improvements to documentation, training, QA, and customer support
  • Adding new tools to enable users to easily create and view custom subsets
• Primarily affects production of the Metathesaurus release files.
• Research branch still heavily involved in continued development

UMLS Community (Slide 18)

UMLS Webcasts (Slide 19)

Future Topics:

• RxNorm
• The Semantic Network

New Web Services Interface to the UMLSKS (Slide 20)

• January/February 2008
  • New backend system released
  • Front end web interface released
  • XSL-based user interface running concurrently
• March 2008
  • Downloadable library Alpha release
• April 2008
  • Web interface redeployment with new features
    • Building of user defined web pages

UMLS - CORE Project (Slide 21)

• CORE = Clinical Observations Recordings and Encoding
• To identify a CORE subset of the UMLS to support consistent high level encoding of clinical information
• Dr. Kin Wah Fung is the project lead

Specific Projects (Slide 22)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

2003- NLM/CAP* License and Contract (Slide 23)

• U.S-wide license for the use of SNOMED CT:
  • Perpetual rights to the last version received under the contract
  • Ongoing updates to the English and Spanish versions for 5 years (follow-on contracts likely)
  • Free distribution to U.S. users via NLM's Unified Medical Language System (UMLS)
  • International use requires separate license from CAP
  • Terms of agreement determined with extensive input/advice from HHS agencies, VA, DOD

*College of American Pathologists

April 26, 2007: Change in ownership announced (Slide 24)

• International Health Terminology Standards Development Organisation (IHTSDO)
  • Charter members from 9 countries:
    • Australia, Canada, Denmark, Lithuania, Netherlands, New Zealand, Sweden, UK, USA
  • Each member country represented by one entity
    • NLM - the initial entity for USA

International Health Terminology Standards Development Organisation (IHTSDO) (Slide 25)

The URL is www.ihtsdo.org/

What Will Be Different for U.S.? (Slide 26)

• Annual fee NLM is paying may decrease over time
• SNOMED CT and its documentation now available in native format from NLM
  • in addition to UMLS format
• Better international distribution rights for US users
• Good prospects for:
  • More transparent governance, priority setting More efficient updating
  • International collaboration on subsets, tools, etc.
  • More commercial products
• NLM developing plan for improving procedures so NLM can effectively represent the needs of U.S. users of SNOMED CT to the IHTSDO.

The URL is www.nlm.nih.gov/snomed

Specific Projects (Slide 27)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

LOINC (Slide 28)

• NLM provides support for the ongoing maintenance and distribution of LOINC via contract mechanism
• Current contract will expire this Spring
• New contract will be put in place

Specific Projects (Slide 28)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

RxNorm (Slide 30)

• 2007 Plans:
  • Continue improving coverage of drug delivery/dispensing devices and multi-vitamins within RxNorm
  • Expand RxNorm to cover over-the-counter medications based on information supplied by selected sources
• Webcast scheduled for January 25, 2008
• More information on Web site:
  • www.nlm.nih.gov/research/umls/rxnorm/index.html

Specific Projects (Slide 31)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

DailyMed (Slide 32)

• Website (dailymed.nlm.nih.gov) designed to provide high quality information about marketed drugs
• Uses the Structured Product Label (SPL) from the FDA
• Note: DailyMed information intended for prescribers and dispersers, not for patients.
  • Information for Patients section is designed to tell prescribers how to talk to their patients about the drug.

DailyMed (Slide 33)

• Site went live in November 2005
• Currently contains 3532 labels
• Expect to have a complete set (~4,500) by the end of the year Will establish links to the published literature,
• ClinicalTrials.gov, and other relevant sources for each drug listed

Specific Projects

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

NLM's basic mapping project assumptions (Slide 35)

• Mappings are sets of relationships of varying complexity established between two vocabularies in order to allow automated translation or connection between them.
  • More specific concepts can generally be mapped accurately to more general concepts.
  • Mappings cannot be used to add specificity to information that was captured at a more generic level

• Participants in the creation of the map must include:
  • Producers of the two vocabularies being mapped
    • The creation of maps is likely to suggest ways to improve the vocabularies
  • Prospective users and recipients of the map (e.g., health care providers, payers) as testers and validators

NLM's basic mapping project assumptions (2) (Slide 36)

• Mappings will be distributed in the UMLS (not exclusively); use will be governed by terms applicable to both ends
• Mapping is still an R & D problem - it requires an iterative process to build highly functional maps. Alignment of update schedules is critical.

Complete list of NLM's Basic Mapping Project Assumptions available at: www.nlm.nih.gov/research/umls/mapping_projects/mapping_assumptions.html

Mapping Projects Underway

• LOINC => CPT
• SNOMED CT => CPT
• SNOMED CT => ICD-9-CM
• SNOMED CT => MeSH

Note: See November 30, 2007 webcast for details on current mapping projects

Mapping Projects Under Discussion (Slide 38)

• SNOMED CT => "other" vocabularies:
  • ICD-10-CM
  • Medical Dictionary for Regulatory Affairs (MedDRA)
  • International Classification of Functioning and Disability (ICF)
  • International Classification of Primary Care (ICPC)
  • Medcin

Specific Projects (Slide 39)

• UMLS
• SNOMED CT
• LOINC
• RxNorm
• DailyMed
• Mapping Projects
• Harmonization between standards

Harmonization Efforts NLM Coordinating (Slide 40)

• SNOMED CT and LOINC
  • NLM facilitating meetings between IHTSDO and Regenstrief
  • Initial meetings are encouraging
• SNOMED CT and RxNorm
  • International solution will be developed for representing drug information
  • RxNorm just one piece of the puzzle

NLM- HL7 Contract Arrangement Sept. 2004 (Slide 41)

• Align HL7 message standard with CHI standard vocabularies (NLM-initiated)
  • Specify which subsets of standard vocabularies are valid for particular message segments
  • Replace HL7-maintained lists of coded values with subsets of standard vocabularies, where feasible
  • Project wraps up during August 2008 HL7 Working Group Meeting

• Create implementation guide(s) for transmitting an entire Electronic Health Record between systems (on behalf of HHS)
  • Project wrapped up during May 2007 Working Group Meeting

Find Out More (Slide 42)

The URL is www.nlm.nih.gov

(Slide 43)

The URL is www.nlm.nih.gov/healthit.html

Questions? (Slide 44)