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Eliminating suffering and death from cancer requires an unprecedented collaborative effort that leverages resources from government, industry, and academia. Working in concert with the National Institute of Standards and Technology (NIST) and the U.S. Food and Drug Administration (FDA), the National Cancer Institute (NCI) established the Nanotechnology Characterization Laboratory to perform preclinical efficacy and toxicity testing of nanoparticles.

The NCL serves as a national resource and knowledge base for all cancer researchers to facilitate the regulatory review of nanotechnologies intended for cancer therapies and diagnostics. By providing the critical infrastructure and characterization services to nanomaterial providers, the NCL accelerates the transition of basic nanoscale particles and devices into clinical applications, thereby reducing suffering and death from cancer.

As part of its assay cascade, the NCL characterizes nanoparticles' physical attributes, their in vitro biological properties, and their in vivo compatibility using animal models. The time required to characterize nanomaterials from receipt through the in vivo phase is approximately one year.

   Learn about the application process to submit materials.

 

 
11.03.2008
NCL is hosting its first nanoparticle immunotoxicity workshop on November 3rd, 2008 at NCI-Frederick. Registration for this workshop is now closed.
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07.08.2008
Method for Analysis of Nanoparticle Hemolytic Properties in Vitro by Marina A. Dobrovolskaia et al.
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05.30.2008
Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution by Marina A. Dobrovolskaia et al. published in Molecular Pharmaceutics
View Abstract
 
05.19.2008
Rapid Distribution of Liposomal Short-Chain Ceramide In Vitro and In Vivo by Banu S. Zolnik et al. published in Drug Metabolism and Disposition
View Abstract
 
03.18.2008
NCL Methods Become ASTM Standards
 
12.31.2007
NCL supports new NIST nanoparticulate reference material.

 
 
         
National Cancer InstituteDepartment of Health and Human ServicesNational Institutes of HealthFirstGov.govNCI - Alliance for Nanotechnology in Cancer
National Cancer Institute U.S. National Institutes of Health www.cancer.gov Nanotechnology Characterization Lab