Fur is a global regulator of bacterial iron uptake systems. We build refined E. coli Fur binding site models using information theory, and use the models to predict Fur binding. As Fur binds as dimer and many Fur binding sites overlap, to disentangle Fur models, future work would be to further refine the models by only using single dimer binding sites. For more details please see Nucleic Acids Res, 2007, 35(20):6762-77.

Left: Comparison of different alignments of Fur binding sites. Right: Sequence walker to test different Fur models.

Comparison of Fur model scan (A) and footprints of the fhuF promoter region (B).