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T7 Group
T7 Islands
T7 Excess
Fur
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Updated: Jan 13, 2008, by Zehua Chen,
zehuaATmitDOTedu
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Using molecular information theory and
other bioinformatics tools to analyze T7-like
phages and their transcription systems
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T7 group
of phages share a similar genome organization and a
unique transcription system, which contains
a phage-encoded single-subunit RNA polymerase and
a set of well-conserved T7-like promoters.
Such a transcription system is a hallmark feature of the T7 group,
and by this criterion, it's easy to tell whether a phage belongs to the
T7 group, or it is just T7-like.
Read more...
T7 excess
information
was originally noticed and characterized by Dr. Schneider in 1986.
Recently we expanded our information theory analysis to all available
genomes of the T7 group, and found that all members of this group have
excess information at their promoters.
We propose that the promoter excess information can be explained
by the takeover ratio, which
was defined as the ratio between information contents of the phage SD and
the corresponding host SD.
A paper about this is in preparation.
- Note: I moved to Boston College,
http://www2.bc.edu/~chenzp.
- July 31, 2007, the
fur paper was accepted by
Nucleic Acids Research.
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June 5, 2006. Talk: by Zehua Chen.
Information theory based DNA binding
site models, 2006 June 9 at the
SuperArray Biosciences Corporation.
Host: Dr. Xiao Zeng.
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April 12, 2006. Talk: by Zehua Chen.
Information theory analysis of
T7-like phages, 2006 June 2 at the
Biology Department of Brookhaven National Laboratory.
Host: Dr. F. William Studier.
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April 12, 2006. Talk: by Zehua Chen.
Discovery of T7 islands using
information theory based T7-like promoter models,
2006 May 12 at the
2006 Texas, Evergreen Phage and Virus Genomics and Ecology Meeting.
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April 12, 2006. Poster: by Zehua Chen.
Takeover pressure explains
excess information at T7-like promoters,
2006 May 12 at the
2006 Texas, Evergreen Phage and Virus Genomics and Ecology Meeting.
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Mar 9, 2006.
We got the cover!
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Feb 21, 2006. The
t7island paper was published in
Nucleic Acids Research, 2006 34(4):1133-1147.
- Nov 1, 2005. The
t7like paper was published in
Nucleic Acids Research, 2005 33(19):6172-6187.
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