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Summaries & Associations of Study Results

Levels from TR-534 Divinylbenzene

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Target Organs and Levels of Evidence
NTP Technical Report Number 534

Produced from Chemtrack Database 02/07/06

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
DIVINYLBENZENE
1321-74-0 		09/27/05 CROSS-LINKING MONOMER FOR COPOLYMERIZATION WITH STYRENE OR WITH ACRYLIC OR METHACRYLIC ACID TO PRODUCE ION-EXCHANGE RESINS USED IN HOME, MUNICIPAL AND INDUSTRIAL WATER TREATMENT AND IN CHEMICAL, FOOD AND PHARMACEUTICAL PROCESSING. USED IN STYRENE-BUTADIENE RUBBER TO IMPROVE THE SWELLING, SHRINKAGE, Inhalation R: 0, 100, 200, OR 400 PPM M: 0, 10, 30, OR 100 PPM Battelle Northwest Laboratory
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: EQUIVOCAL EVIDENCE KIDNEY TUBULAR CELL: CARCINOMA (STANDARD EVALUATION) 0/50 0/49 0/50 2/49 ADENOMA OR CARCINOMA (STANDARD AND EXTENDED EVALUATIONS) 0/50 0/49 2/50 3/49
BRAIN: OLIGODENDROGLIOMA OR ASTROCYTOMA 0/49 1/50 3/50 0/50
NON-NEOPLASTIC LESIONS: NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA; GLANDULAR DILATATION; GOBLET CELL HYPERPLASIA
FR: NO EVIDENCE
NON-NEOPLASTIC LESIONS: NASAL CAVITY: EPITHELIAL DEGENERATION; BASAL CELL EPITHELIAL HYPERPLASIA
MM: NO EVIDENCE
NON-NEOPLASTIC LESIONS: LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION
FM: EQUIVOCAL EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 12/50 8/50 13/49
NON-NEOPLASTIC LESIONS: LUNG: ATYPICAL BRONCHIOLAR HYPERPLASIA; ALVEOLAR EPITHELIAL HYPERPLASIA
NASAL CAVITY: SUPPURATIVE INFLAMMATION; GLANDULAR RESPIRATORY EPITHELIAL METAPLASIA; EPITHELIAL RESPIRATORY METAPLASIA; HYALINE EPITHELIAL DEGENERATION

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