University of Washington
Department of Environmental and Occupational Health Sciences
4225 Roosevelt Way NE #100
Box 354695
Seattle, WA 98105-6099
Phone: 206-685-8479
Fax: 206-685-4696
Email:
University of Washington: Training Core (1995 - 2006)
Publications
2007
Giordano, Gennaro, Zahra Afsharinejad, Marina Guizzetti, Annabella Vitalone, Terrance J. Kavanagh, and Lucio G. Costa. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 219(2-3):181-189.
2006
Bekris, Lynn M., Hanna A. Viernes, Federico M. Farin, Lisa A. Maier, Terrance J. Kavanagh, and Timothy K. Takaro. 2006. Chronic beryllium disease and glutathione biosynthesis genes. Journal of Occupational and Environmental Medicine. (http://www.joem.org/) 48(6):599-606.
Botta, Dianne, Shengli Shi, Collin C. White, Michael J. Dabrowski, Cassie L. Keener, Sengkeo L. Srinouanprachanh, Federico M. Farin, Carol B. Ware, Warren C. Ladiges, Robert H. Pierce, Nelson Fausto, and Terrance J. Kavanagh. 2006. Acetaminophen-induced Liver Injury Is Attenuated in Male Glutamate-cysteine Ligase Transgenic Mice. Journal of Biological Chemistry. (http://www.jbc.org/) 281(39):28865-28875.
2004
Botta, Dianne, Christopher C. Franklin, Collin C. White, Cecile M. Krejsa, Michael J. Dabrowski, Robert H. Pierce, Nelson Fausto, and Terrance J. Kavanagh. 2004. Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Free Radical Biology and Medicine. 37(5):632-642.
Diaz, Delores, Cecile M. Krejsa, Collin C. White, Jay S. Charleston, and Terrance J. Kavanagh. 2004. Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development. Reproductive Toxicology. (http://www.sciencedirect.com/science/journal/ 08906238) 19(1):117-129.
Kevil, Christopher G., Heather M. Pruitt, Terrance J. Kavanagh, Jasmine Wilkerson, Federico M. Farin, D. Moellering, Victor M. Darley-Usmar, Daniel C. Bullard, and Rakesh P. Patel. 2004. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB Journal. (http://www.fasebj.org/) 18(11):1321-3.
Krzywanski, David M., Dale A. Dickinson, Karen E. Iles, Amanda F. Wigley, Christopher C. Franklin, Rui-Ming Liu, Terrance J. Kavanagh, and Henry Jay Forman. 2004. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) 423(1):116-125.
Tran, Phuong Oanh T., Sarah M. Parker, Eric LeRoy, Christopher C. Franklin, Terrance J. Kavanagh, Tao Zhang, Huarong Zhou, Portia A. Vliet, Elizabeth Oseid, Jamie S. Harmon, and R. Paul Robertson. 2004. Adenoviral overexpression of the glutamylcysteine ligase catalytic subunit protects pancreatic islets against oxidative stress. Journal of Biological Chemistry. (http://www.jbc.org/) 279(52):53988-53993.
2003
Barrus, H., Sengkeo L. Srinouanprachanh, Michael J. Hooper, George P. Cobb, and Terrance J. Kavanagh. 2003. Metallothionein and glutamate-cysteine ligase gene expression in metal-exposed small mammals. In: Proceedings of the 42nd Annual Meeting of the Society of Toxicology (SOT), March 9-13, 2003. Salt Lake City, UT.
Bea, Florian, Francesca N. Hudson, Alan Chait, Terrance J. Kavanagh, and Michael E. Rosenfeld. 2003. Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements. Circulation Research. (http://circres.ahajournals.org/) 92(4):386-393.
Bekris, Lynn M., Cindy Shephard, M. Zarghami, W.C. Griffith, Terrance J. Kavanagh, and Ake Lernmark. 2003. Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type I diabetes. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 72(1):480Suppl.S.
Franklin, Christopher C., Maryland E. Rosenfeld-Franklin, Collin C. White, Terrance J. Kavanagh, and Nelson Fausto. 2003. TGF beta 1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent posttranslational and caspase-independent transcriptional regulatory mechanisms. FASEB Journal. (http://www.fasebj.org/) 17(11):1535-1537.
Garry, M.R., Jaspreet S. Sidhu, Terrance J. Kavanagh, and Elaine M. Faustman. 2003. Differential modulation of stress and ubiquitination signaling pathways by cadmium, H202, and serum withdrawal in cultured mouse fibroblasts. Society of Toxicology 42nd annual Meeting in Salt Lake City, Utah, March 2003. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 72(1):311Suppl.S.
Kavanagh, Terrance J., Shengli Shi, Dianne Botta, Collin C. White, Michael J. Dabrowski, Cindy Shephard, Sean D. Quigley, Federico M. Farin, Richard Beyer, Robert H. Pierce, Christopher C. Franklin, Helmet F. Zarbl, and Theodor K. Bammler. 2003. Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 72(1):805Suppl.S.
Luderer, Ulrick, Delores Diaz, Elaine M. Faustman, and Terrance J. Kavanagh. 2003. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Molecular Reproduction and Development. (http://www3.interscience.wiley.com/journal/37 692/home) 65(3):254-261.
Shao, Jianhua, E.F. McKone, Cassie L. Keener, Cindy Shephard, Federico M. Farin, M.L. Aitken, and Terrance J. Kavanagh. 2003. The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 72(1):487Suppl.S.
Shi, Shengli, Dianne Botta, Collin C. White, Michael J. Dabrowski, Cindy Shephard, Sean D. Quigley, Federico M. Farin, Richard Beyer, Robert H. Pierce, Christopher C. Franklin, Helmet F. Zarbl, Theodor K. Bammler, and Terrance J. Kavanagh. 2003. Effects of enhanced glutathione synthesis on carbon tetracholoride-induced differential gene expression in glutamate-cysteine ligase transgenic mice livers. Free Radical Biology and Medicine. 35(1):227Suppl.S.
Shi, Shengli, M.B. Hendsch, C.E. Ogburn, Peter S. Rabinovitch, G.M. Martin, and Terrance J. Kavanagh. 2003. Female mice transgenic for mitochondrial directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 72(1):394Suppl.S.
Thompson, J.A., Terrance J. Kavanagh, Collin C. White, Nelson Fausto, and Christopher C. Franklin. 2003. Distinct molecular mechanisms mediate AS3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes. Free Radical Biology and Medicine Annual Meeting, Seattle, WA, November 2003. Free Radical Biology and Medicine. 35:188Suppl.1.
White, Collin C., Hanna A. Viernes, Cecile M. Krejsa, Dianne Botta, and Terrance J. Kavanagh. 2003. Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) 318(2):175-180.
2002
Diaz, Delores, Cecile M. Krejsa, and Terrance J. Kavanagh. 2002. Expression of glutamate-cysteine ligase during mouse development. Molecular Reproduction and Development. (http://www3.interscience.wiley.com/journal/37 692/home) 62:83-91.
Faustman, Elaine M., Rafael A. Ponce, Ying C. Ou, Ma Aileen C. Mendoza, Thomas A. Lewandowski, and Terrance J. Kavanagh. 2002. Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives. 110(Supp5):859-864.
Franklin, Christopher C., Cecile M. Krejsa, Robert H. Pierce, Collin C. White, Nelson Fausto, and Terrance J. Kavanagh. 2002. Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death. American Journal of Pathology. (http://ajp.amjpathol.org/) 160(5):1887-1894.
2001
Adams, Michael L., Robert H. Pierce, Mary E. Vail, Collin C. White, Robert P. Tonge, Terrance J. Kavanagh, Nelson Fausto, Sidney D. Nelson, and Sam A. Bruschi. 2001. Enhanced Acetaminophen Hepatotoxicity in Transgenic Mice Overexpressing BCL-2. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) 60(5):907-915.
Diaz, Delores, Cecile M. Krejsa, and Terrance J. Kavanagh. 2001. Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) 123(1):33-41.
Diaz, Delores, Cecile M. Krejsa, Collin C. White, Cassie L. Keener, Federico M. Farin, and Terrance J. Kavanagh. 2001. Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) 122(2):119-129.
Luderer, Ulrick, Terrance J. Kavanagh, Collin C. White, and Elaine M. Faustman. 2001. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reproductive Toxicology. (http://www.sciencedirect.com/science/journal/ 08906238) 15:495-504.
Rosato, Michael T., Abdallah J. Jabbour, Rafael A. Ponce, Terrance J. Kavanagh, Timothy K. Takaro, Juliane P. Hill, Martin Poot, Peter S. Rabinovitch, and Elaine M. Faustman. 2001. Simultaneous analysis of surface marker expression and cell cycle progression in human peripheral blood mononuclear cells. Journal of Immunological Methods. 256(1-2):35-46.
2000
Hudson, Francesca N. and Terrance J. Kavanagh. 2000. Cloning and characterization of the proximal promoter region of the mouse glutamate-L-cysteine ligase regulatory subunit gene. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) 1492:447-451.
Jarvinen, Kristiina, Petra Pietarinen-Runtti, Kaija Linnainmaa, Kari O. Raivio, Cecile M. Krejsa, Terrance J. Kavanagh, and Vuokko L. Kinnula. 2000. Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells. American Journal of Physiology-Lung Cellular and Molecular Physiology. (http://ajplung.physiology.org/) 278(4):L696-702.
Kirlin, Ward G., Jiyang Cai, Sally A. Thompson, Delores Diaz, Terrance J. Kavanagh, and Dean P. Jones. 2000. Glutathione redox potential in response to differentiation and enzyme inducers. Free Radical Biology and Medicine. 27(11-12):1208-1218.
Pierce, Robert H., Jean S. Campbell, Alyssa B. Stephenson, Christopher C. Franklin, M. Chaisson, Martin Poot, Terrance J. Kavanagh, Peter S. Rabinovitch, and Nelson Fausto. 2000. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. American Journal of Pathology. (http://ajp.amjpathol.org/) 157(1):221-36.
Thompson, Sally A., Collin C. White, Cecile M. Krejsa, David L. Eaton, and Terrance J. Kavanagh. 2000. Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 57:141-6.
1999
Nelson, Kasey C., Joanne L. Carlson, Melanie L. Newman, Paul Sternberg, Dean P. Jones, Terrance J. Kavanagh, Delores Diaz, Jiyang Cai, and Min Wu. 1999. Effect of dietary inducer dimethylfumarate on glutathione in cultured retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. (http://www.iovs.org/) 40(9):1927-1935.
Ou, Ying C., Sally A. Thompson, Rafael A. Ponce, Julian I. Schroeder, Terrance J. Kavanagh, and Elaine M. Faustman. 1999. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 157:203-212.
Ou, Ying C., Collin C. White, Cecile M. Krejsa, Rafael A. Ponce, Terrance J. Kavanagh, and Elaine M. Faustman. 1999. The Role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. NeuroToxicology. (http://www.neurotoxicology.com/) 20:784-793.
Siitonen, T., P. Alaruikka, P. Mantymaa, E.R. Savolainen, Terrance J. Kavanagh, Cecile M. Krejsa, Christopher C. Franklin, Vuokko L. Kinnula, and P. Koistinen. 1999. Protection of acute myeloblastic leukemia cells against apoptotic cell death by high glutathione and gamma-glutamylcysteine synthetase levels during etoposide-induced oxidative stress. Annals of Oncology. (http://www.wkap.nl/journalhome.htm/0923-7534) 10(11):1361-1367.
Thompson, Sally A., Collin C. White, Cecile M. Krejsa, Delores Diaz, James S. Woods, and Terrance J. Kavanagh. 1999. Induction of glutamate-cysteine ligase in the brains of adult female mice sub-chronically exposed to methylmercury. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) 110:1-10.
Woods, James S., Terrance J. Kavanagh, Jeannette Corral, Annabelle W. Reese, Delores Diaz, and Maureen E. Ellis. 1999. The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 160(3):207-216.
1998
Broudy, Virginia C., Nancy L. Lin, Hans-Jorg Buhring, Norio Komatsu, and Terrance J. Kavanagh. 1998. Analysis of c-Kit receptor dimerization by fluorescence resonance energy transfer. Blood. (http://www.bloodjournal.org/) 91:898-906.
Calverley, David C., Terrance J. Kavanagh, and Gerald J. Roth. 1998. Human signaling protein 14-3-3 zeta interacts with platelet glycoprotein Ib subunits Ib alpha and Ib beta. Blood. (http://www.bloodjournal.org/) 91(4):1295-1303.
Ponce, Rafael A., Scott M. Bartell, Terrance J. Kavanagh, James S. Woods, Robert C. Lee, Timothy K. Takaro, and Elaine M. Faustman. 1998. Uncertainty analysis methods for comparing predictive models and biomarkers: A case study of dietary methylmercury exposures. Regulatory Toxicology and Pharmacology. 28(2):96-105.
Thompson, Sally A., K.L. Roellich, Angelika Grossmann, Steven G. Gilbert, and Terrance J. Kavanagh. 1998. Alterations in immune parameters associated with low level methylmercury exposure in mice. Immunopharmacology and Immunotoxicology. (http://www.informaworld.com/smpp/title~conten t=t713597257) 20(2):299-314.
1997
Krejsa, Cecile M., Steven G. Nadler, James M. Esselstyn, Terrance J. Kavanagh, Jeffery A. Ledbetter, and Gary L. Schieven. 1997. Role of oxidative stress in the action of vanadium phosphotyrosine phosphotase inhibitors: Redox independent activation of NF-ÇB. Journal of Biological Chemistry. (http://www.jbc.org/) 272(17):11541-11549.
Ou, Ying C., Sally A. Thompson, Sandy C. Kirchner, Terrance J. Kavanagh, and Elaine M. Faustman. 1997. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 147:31-38.
Potter, Alan J., Angelika Grossmann, Peter S. Rabinovitch, David L. Eaton, and Terrance J. Kavanagh. 1997. The effect of in vitro phorone exposure on glutathione content and T-cell antigen receptor stimulated calcium mobilization in murine splenic T lymphocytes. In Vitro & Molecular Toxicology. (http://www.liebertonline.com/ivt?cookieSet=1) 11(4):355-363.
Reid, Lynnda L., Dianne Botta, Y. Lu, Evan P. Gallagher, and Terrance J. Kavanagh. 1997. Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) 1352(2):233-237.
Reid, Lynnda L., Dianne Botta, Jianhua Shao, Francesca N. Hudson, and Terrance J. Kavanagh. 1997. Molecular cloning and sequencing of the cDNA encoding mouse glutamate-cysteine ligase regulatory subunit. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) 1353:107-110.
1996
Heinonen, John T., Jaspreet S. Sidhu, Maureen T. Reilly, Federico M. Farin, Curtis J. Omiecinski, David L. Eaton, and Terrance J. Kavanagh. 1996. Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Environmental Health Perspectives. 104(5):535-543.
Krejsa, Cecile M., Steven G. Nadler, James M. Esselstyn, Terrance J. Kavanagh, Jeffery A. Ledbetter, and Gary L. Schieven. 1996. The differenetial role of oxidative stress in the activation of protein tyrosine kinases, MAP kinase, and NF-χB by vanadium phosphotyrosine phosphatase inhibitors. FASEB Journal. (http://www.fasebj.org/) 10(6):P10.
Li, Sue, Sally A. Thompson, Terrance J. Kavanagh, and James S. Woods. 1996. Localization by in situ hybridizatioin of glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 141:59-67.
Poot, Martin, Francesca N. Hudson, Angelika Grossmann, Peter S. Rabinovitch, and Terrance J. Kavanagh. 1996. Probenicid inhibition of fluorescence extrusion after MCB-staining of rat-1 fibroblasts. Cytometry. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=33945) 23(1):78-81.
1995
Grossmann, Angelika, Peter S. Rabinovitch, Terrance J. Kavanagh, John C. Jinneman, Lisa K. Gilliland, Jeffery A. Ledbetter, and Steven B. Kanner. 1995. Activation of murine T-cells via phospholipase-Cg1-associated protein tyrosine phosphorylation is reduced with aging. Journals of Gerontology. (http://biomed.gerontologyjournals.org/) 50(4):B205-B212.
Krejsa, Cecile M., Jeffery A. Ledbetter, and Terrance J. Kavanagh. 1995. Oxidant induced changes in red autofluorescence in lymphocytes and lymphoblastoid cell lines correlates with decreased glutathione. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) 15:158a.
Poot, Martin, Heidi Teubert, Peter S. Rabinovitch, and Terrance J. Kavanagh. 1995. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. Journal of Cellular Physiology. (http://www.interscience.wiley.com/jpages/0021 -9541/) 163(3):555-560.
Reid, Lynnda L. and Terrance J. Kavanagh. 1995. Cloning and sequencing of the mouse cDNAs encoding the light and heavy subunits of g-glutamylcysteine synthetase. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) 15:1613a.
Thompson, Sally A., Angelika Grossmann, Collin C. White, David L. Eaton, Steven G. Gilbert, and Terrance J. Kavanagh. 1995. Strain specific effects of sub-chronic, low level methylmercury exposure on GSH levels in mice. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) 15:1616a.
219(2-3):181-189. 
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