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Seeing signaling protein activation in cells 01

ID Number
2451

Description
Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. In order to fulfill these diverse roles, the timing and location of Cdc42 activation must be tightly controlled. Klaus Hahn and his research group use special dyes designed to report protein conformational changes and interactions, here in living neutrophil cells. Warmer colors in this image indicate higher levels of activation. Cdc42 looks to be activated at cell protrusions.

Type
Photograph

Source
Klaus Hahn, University of North Carolina, Chapel Hill Medical School

Credit Line
Klaus Hahn, University of North Carolina, Chapel Hill Medical School

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