The General Practice Research Database (GPRD)
Description
GPRD, managed by the Secretary of State for Health, United Kingdom (UK) contains over 3 million active patient records drawn from approximately 400 primary care practices in the UK. The Medicine Control Agency manages the GRPD and has initiated a program to enable broader research use of the data both within the UK and overseas. The GPRD is the world's largest database of anonymized longitudinal primary care medical records. The database has clinical and prescription data and can provide information to support pharmacovigilance (indication, utilization, and risk/benefit profiles of drugs) and formal pharmacoepidemiologic studies, including information on demographics, medical symptoms, therapy (medicines, vaccines, devices), and treatment outcomes. The GPRD can provide data for both clinical and academic researchers and over 400 articles published in peer-reviewed journals have used data from the GPRD. For academic researchers, simple feasibility counts of patients and events for specified diseases or prescriptions are free of charge. Aggregated data tables can be provided, at a cost that varies with the complexity of the request. Patient-level data sets also can be provided.
Selected References
Utilization
Bradbury BD, Lash TL, Kaye JA, Jick SS.
Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed angina.
Cancer. 2005 Mar 15;103(6):1114-21.
Etiology
Kaye JA, Jick H.
Antibiotics and the risk of breast cancer.
Epidemiology. 2005 Sep;16(5):688-90.
Gonzalez-Perez A, Garcia Rodriguez LA.
Breast cancer risk among users of antidepressant medications.
Epidemiology 2005 Jan;16(1):101-5.
van Staa TP, Card T, Logan RF, Leufkens HG.
5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study.
Gut 2005 Nov;54(11):1573-8.
Meier CR, Derby LE, Jick SS, Jick H.
Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancer.
Arch Intern Med 2000 Feb 14;160(3):349-53.
Langman MJ, Cheng KK, Gilman EA, Lancashire RJ.
Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database.
BMJ 2000 Jun 17;320(7250):1642-6.
Garcia-Rodriguez LA, Huerta-Alvarez C.
Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.
Epidemiology 2001 Jan;12(1):88-93.
Meier CR, Schmitz S, Jick H.
Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer.
Pharmacotherapy 2002 Mar;22(3):303-9.
Kaye JA, Myers MW, Jick H.
Acetaminophen and the risk of renal and bladder cancer in the general practice research database.
Epidemiology. 2001 Nov;12(6):690-4.
Kaye JA, Jick H.
Statin use and cancer risk in the General Practice Research Database.
Br J Cancer. 2004 Feb 9;90(3):635-7.
Gelfand JM, Shin DB, Neimann AL, Wang X, Margolis DJ, Troxel AB.
The risk of lymphoma in patients with psoriasis.
J Invest Dermatol 2006 Oct;126(10):2194-201.
Hogler W, Wehl G, van Staa T, Meister B, Klein-Franke A, Kropshofer G.
Incidence of skeletal complications during treatment of childhood acute lymphoblastic leukemia: comparison of fracture risk with the General Practice Research Database.
Pediatr Blood Cancer. 2007 Jan;48(1):21-7.
Gonzalez-Perez A, Garcia Rodriguez LA.
Prostate cancer risk among men with diabetes mellitus (Spain).
Cancer Causes Control 2005 Nov;16(9):1055-8.
Population Burden
Lewis JD, Bilker WB, Weinstein RB, Strom BL.
The relationship between time since registration and measured incidence rates in the General Practice Research Database.
Pharmacoepidemiol Drug Saf 2005 Jul;14(7):443-51.
West J, Logan RF, Smith CJ, Hubbard RB, Card TR.
Malignancy and mortality in people with coeliac disease: population based cohort study.
BMJ 2004 Sep 25;329(7468):716-9. Epub 2004 Jul 21.
Kaye JA, Derby LE, del Mar Melero-Montes M, Quinn M, Jick H.
The incidence of breast cancer in the General Practice Research Database compared with national cancer registration data.
Br J Cancer 2000 Dec;83(11):1556-8.
Cost/Cost Effectiveness
Tooley PJ, Cookson RF, Jones M, Nuyts GD. Medical events and resource utilisation in cancer-pain patients treated with strong opioids: an analysis of the UK General Practice Research Database. J Outcomes Res 2000;4:1-14.
Dolan P, Torgerson DJ, Wolstenholme J.
Costs of breast cancer treatment in the United Kingdom.
Breast 1999 Aug;8(4):205-7.
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