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WB: Rat brain homogenates were either untreated (lane 1) or treated with Protein Kinase C (lane 2) and probed with anti-phospho-Neurogranin (Ser36)/N ...
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, H, M, R | WB | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: Q92686 # Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
SIZE: 78 amino acids; 7618 Da
SIMILARITY: SwissProt: Q92686 ## Belongs to the neurogranin family. & Contains 1 collagen-like domain. & Contains 1 IQ domain.
SIZE: 78 amino acids; 7618 Da
SIMILARITY: SwissProt: Q92686 ## Belongs to the neurogranin family. & Contains 1 collagen-like domain. & Contains 1 IQ domain.
Entrez Gene Number:
Entrez Gene Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the conseque
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Description:
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41)
Specificity:
phosphorylated Neurogranin and Neuromodulin
Key Applications:
Western Blotting
Species Reactivity:
- Bovine
- Human
- Mouse
- Rat
Isotype:
IgG
Immunogen:
Peptide corresponding to amino acids 35-47 of rat neuromodulin.
Modifications:
Phosphorylation
Molecular Weight:
7-17kDa and 43-45kDa.
Presentation:
0.05% sodium azide and 30% glycerol
Storage Conditions:
2 years at -20°C
Gene Symbol:
- NRGN
- neurogranin
- Ng
- Neurogranin
- hng
- RC3
Quality Assurance:
routinely evaluated by immunoblot in RIPA lysates from rat brain extract which had been phosphorylated by 500ng of Protein Kinase C
Antibody Category:
Neuroscience
Antibody Sub-Category:
Signaling Neuroscience
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Descriptive Text:
Neurogranin (RC3) and Neuromodulin (GAP-43) neuronal calmodulin-binding proteins. Both proteins are substrates for PKC; phosphorylation reduces their calmodulin-binding affinities. The proteins have been implicated in diverse functions, including mobilization of Ca2+ in response to mGluR stimulation, long-term potentiation, and neuronal development and remodeling.
Trade Name:
Upstate (Millipore)
Purification Method:
antiserum
Format:
Serum
Antibody Type:
Polyclonal Antibody
Host:
Rabbit