ECM Biosciences

Antibodies and their Designated Sites (count: 35)
Gene/Protein Phosphorylation Sites Antibodies
Symbol
Name 		Site Name Alt Res Names Local Sequence MPR Site ID Refs Antibody Name (Cat#) Co. Polyclonal (species) OR Mono. (isotype; clone)
ABL1
abl1
Genbank LocusLink 		Alt. gene names: abelson strain of murine leukemia viral oncogene homolog 1; abl1; c-abl; abl; p150;
Y226 T245 KPTVpYGVSP 263
c-Abl (Tyr-245), phospho-specific (AP1251) c-Abl (Tyr-245), phospho-specific ECM Biosciences P (Rabbit)
Y393 Y412 TGDTpYTAHA 417
c-Abl (Tyr-412), phospho-specific (AP1271) c-Abl (Tyr-412), phospho-specific ECM Biosciences P (Rabbit)
AKT1
Akt1
Genbank LocusLink 		Alt. gene names: protein Kinase B; PKB; Akt1; AKT; C-AKT; RAC-alpha serine/threonine kinase; RAC; rac alpha; rac-pk alpha;
S473 FPQFpSYSAS 12 1, 2, 3, 4, 5, 6, 8, 9
Akt (Ser-473), phospho-specific (AM1141) Akt (Ser-473), phospho-specific ECM Biosciences M (IgG1; )
BCR
BCR
Genbank LocusLink 		Alt. gene names: breakpoint cluster region; BCR;
Y177 EKPFpYVNVE 364
Akt (Thr-34), phospho-specific (AP1001) Akt (Thr-34), phospho-specific ECM Biosciences P (Rabbit)
ITGB4
beta-4 integrin
Genbank LocusLink 		Alt. gene names: CD104; beta 4 integrin chain; tumor specific protein 180 antigen; TSP-1180;
Y1564 Y1494 YSVEpYQLLN 670
Integrin-beta4 (Tyr-1494), phospho-specific (IP1281) Integrin-beta4 (Tyr-1494), phospho-specific ECM Biosciences P (Rabbit)
Y1596 Y1526 PNHSpYVFRV 671
Integrin-beta4 (Tyr-1526), phospho-specific (IP1291) Integrin-beta4 (Tyr-1526), phospho-specific ECM Biosciences P (Rabbit)
CTNNB1
beta-catenin
Genbank LocusLink 		Alt. gene names: beta catenin;
Y86 IDGQpYAMTR 665
ß-Catenin (Tyr-86), phospho-specific (CP1191) ß-Catenin (Tyr-86), phospho-specific ECM Biosciences P (Rabbit)
Y142 NLINpYQDDA 666
ß-Catenin (Tyr-142), phospho-specific (CP1081) ß-Catenin (Tyr-142), phospho-specific ECM Biosciences P (Rabbit)
DAG1
beta-dystroglycan
Genbank LocusLink 		Alt. gene names: beta-dystroglycan; beta-DG; dystrophin-associated glycoprotein 1; DAG1; 156DAG; A2; alpha dystroglycan;
Y892 Y239 SPPPpYVPP- 314
gamma-Dystroglycan (Tyr-892), phospho-specific (DM1171) gamma-Dystroglycan (Tyr-892), phospho-specific ECM Biosciences M (IgG1; )
CFL1
cofilin 1
Genbank LocusLink 		Alt. gene names: cofilin 1; cofilin non-muscle isoform;
S3 --MApSGVAV 93
Cofilin 1 (Ser-3), phospho-specific (CP1151) Cofilin 1 (Ser-3), phospho-specific ECM Biosciences P (Rabbit)
PTK2
FAK
Genbank LocusLink 		Alt. gene names: focal adhesion kinase; FAK; FADK; pp125fak; focal adhesion kinase 1; FAK1;
Y397 ETDDpYAEII 27 7
FAK (Tyr-397), phospho-specific (FM1211) FAK (Tyr-397), phospho-specific ECM Biosciences M (IgG1; )
JUP
gamma-catenin
Genbank LocusLink 		Alt. gene names: desmoplakin III; DPIII; DP3; plakoglobin;
Y550 TQQPpYTDGV 667
gamma-Catenin (Tyr-550), phospho-specific (CP1121) gamma-Catenin (Tyr-550), phospho-specific ECM Biosciences P (Rabbit)
GSK3A
GSK-3alpha
Genbank LocusLink 		Alt. gene names: glycogen synthase kinase-3 alpha; GSK-3alpha;
Y279 PNVSpYICSR 35
GSK-3a/ß (Tyr-279/Tyr-216), phospho-specific (GM1321) GSK-3a/ß (Tyr-279/Tyr-216), phospho-specific ECM Biosciences M (IgG1; )
GSK3B
GSK-3beta
Genbank LocusLink 		Alt. gene names: glycogen synthase kinase-3 beta; GSK-3beta; Zw3;
Y216 Y279 PNVSpYICSR 312
GSK-3a/ß (Tyr-279/Tyr-216), phospho-specific (GM1321) GSK-3a/ß (Tyr-279/Tyr-216), phospho-specific ECM Biosciences M (IgG1; )
ERBB2
HER-2
Genbank LocusLink 		Alt. gene names: erythroblastic leukemia viral oncogene homolog 2; ErbB-2; HER-2; neu;
Y1112 Y215 PLQRpYSEDP 216
c-Src (Tyr-215), phospho-specific (SP1371) c-Src (Tyr-215), phospho-specific ECM Biosciences P (Rabbit)
NFKBIA
IkB alpha
Genbank LocusLink 		Alt. gene names: I kappa B alpha; IkBa; IkappaBalpha;
Y42 KDEEpYEQMV 668
IkBalpha (Tyr-42), phospho-specific (IP1031) IkBalpha (Tyr-42), phospho-specific ECM Biosciences P (Rabbit)
Y305 DELPpYDDCV 669
IkBalpha (Tyr-305), phospho-specific (IP1041) IkBalpha (Tyr-305), phospho-specific ECM Biosciences P (Rabbit)
CDH2
N-cadherin
Genbank LocusLink 		Alt. gene names: neural cadherin; N-cadherin;
Y820 AEPQpYPVRS 1082
Anti-N-Cadherin (Tyr-820), phospho-specificRabbit Polyclonal (CP1801) Anti-N-Cadherin (Tyr-820), phospho-specificRabbit Polyclonal ECM Biosciences P (Rabbit)
Anti-Unphosphorylated-N-Cadherin (Tyr-820) Rabbit Polyclonal (CP1851) Anti-Unphosphorylated-N-Cadherin (Tyr-820) Rabbit Polyclonal ECM Biosciences P (Rabbit)
Y860 LVFDpYEGSG 1083
Anti-N-Cadherin (Tyr-860), phospho-specificRabbit Polyclonal (CP1951) Anti-N-Cadherin (Tyr-860), phospho-specificRabbit Polyclonal ECM Biosciences P (Rabbit)
WASL
N-WASP
Genbank LocusLink 		Alt. gene names: Neural Wiskott-Aldrich Syndrome Protein;
Y256 LKVIpYDFIE 690
N-WASP (Tyr-256), phospho-specific (WP2601) N-WASP (Tyr-256), phospho-specific ECM Biosciences P (Rabbit)
S484 KAIHpSSDED 687
unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) (WP2401) unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) ECM Biosciences P (Rabbit)
WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific (WP2201) WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific ECM Biosciences P (Rabbit)
S485 AIHSpSDEDE 688
unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) (WP2401) unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) ECM Biosciences P (Rabbit)
WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific (WP2201) WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific ECM Biosciences P (Rabbit)
BCAR1
p130CAS
Genbank LocusLink 		Alt. gene names: Crk-associated substrate p130Cas; p130CAS; CAS;
Y664 Y668, Y762 WMEDpYDYVH 672
p130 Cas (Tyr-762), phospho-specific (PP1451) p130 Cas (Tyr-762), phospho-specific ECM Biosciences P (Rabbit)
PAK6
PAK6
Genbank LocusLink 		Alt. gene names: p21-activated kinase 6; PAK6;
S165 PEPQpSPRVL 673
PAK6 (Ser-165), phospho-specific (PP1551) PAK6 (Ser-165), phospho-specific ECM Biosciences P (Rabbit)
PXN
paxillin
Genbank LocusLink 		Alt. gene names: paxillin; PXN;
Y31 EETPpYSYPT 42
Paxillin (Tyr-31), phospho-specific (PM1021) Paxillin (Tyr-31), phospho-specific ECM Biosciences M (IgG1; )
S85 S83 PQSSpSPVYG 674
Paxillin (Ser-83), phospho-specific (PP1341) Paxillin (Ser-83), phospho-specific ECM Biosciences P (Rabbit)
S178 PGALpSPLYG 675
Paxillin (Ser-178), phospho-specific (PP1051) Paxillin (Ser-178), phospho-specific ECM Biosciences P (Rabbit)
PDPK1
PDK1
Genbank LocusLink 		Alt. gene names: upstream PKB kinase; USK; Protein kinase B kinase; PKBK; phospholipid-dependent protein kinase 1; PDK1; 3-phosphoinositide dependent protein kinase-1; phosphorylated by 3-phosphoinositide-dependent kinase 1;
Y9 TSQLpYDAVP 676
PDK1 (Tyr-9), phospho-specific (PP1431) PDK1 (Tyr-9), phospho-specific ECM Biosciences P (Rabbit)
PRKCA
pkc-alpha
Genbank LocusLink 		Alt. gene names: pkc-alpha;
S657 FEGFpSYVNP 599
PKCalpha (Ser-657/Tyr-658), phospho-specific (PP1091) PKCalpha (Ser-657/Tyr-658), phospho-specific ECM Biosciences P (Rabbit)
Y658 EGFSpYVNPQ 677
PKCalpha (Ser-657/Tyr-658), phospho-specific (PP1091) PKCalpha (Ser-657/Tyr-658), phospho-specific ECM Biosciences P (Rabbit)
PRKCB1
PKC-beta1
Genbank LocusLink 		Alt. gene names: pkc-beta; PRKCB1;
S661 FAGFpSYTNP 678
PKCalpha (Ser-657/Tyr-658), phospho-specific (PP1091) PKCalpha (Ser-657/Tyr-658), phospho-specific ECM Biosciences P (Rabbit)
Y662 AGFSpYTNPE 679
PKCalpha (Ser-657/Tyr-658), phospho-specific (PP1091) PKCalpha (Ser-657/Tyr-658), phospho-specific ECM Biosciences P (Rabbit)
PLCG1
PLC-gamma 1
Genbank LocusLink 		Alt. gene names: phospholipase C gamma-1; PLC-gamma 1; PLC1; PLCG1; phospholipase C-148; PLC148;
Y775 YGALpYEGRN 680
PLC-gamma1 (Tyr-775) (PP1491) PLC-gamma1 (Tyr-775) ECM Biosciences P (Rabbit)
RHOA
RhoA
Genbank LocusLink 		Alt. gene names: RhoA; Rho A;
S188 GKKKpSGCLV 681
RhoA (Ser-188), phospho-specific (RP1361) RhoA (Ser-188), phospho-specific ECM Biosciences P (Rabbit)
PTPN6
SHP-1
Genbank LocusLink 		Alt. gene names: Src homology 2 domain phosphatase-1; SHP-1; protein tyrosine phosphatase 1C; PTP1C; PTP-N6; SHPTP-1; hematopoietic cell phophatase; HCP;
Y536 QESEpYGNIT 689
SHP1 (Tyr-536) (SP1571) SHP1 (Tyr-536) ECM Biosciences P (Rabbit)
S591 Y593 KSKGpSLKRK 682
SHP1 (Ser-591) (SP1531) SHP1 (Ser-591) ECM Biosciences P (Rabbit)
STAT1
STAT1
Genbank LocusLink 		Alt. gene names: signal transducer and activator of transcription 1; STAT1; transcription factor ISGF-3 components p91/p84; ISGF-3;
Y701 KGTGpYIKTE 49
Stat1 (Tyr-701), phospho-specific (SM1351) Stat1 (Tyr-701), phospho-specific ECM Biosciences M (IgG1; )
STAT5A
STAT5A
Genbank LocusLink 		Alt. gene names: Signal Transducers and Activators of Transcription 5a; STAT5A; mammary gland factor; MGF;
Y694 AVDGpYVKPQ 311
Stat5 (Tyr-694), phospho-specific (SM1481) Stat5 (Tyr-694), phospho-specific ECM Biosciences M (IgG1; )
STAT5B
STAT5B
Genbank LocusLink 		Alt. gene names: Signal Transducers and Activators of Transcription 5b; STAT5B;
Y699 AVDGpYVKPQ 583
Stat5 (Tyr-694), phospho-specific (SM1481) Stat5 (Tyr-694), phospho-specific ECM Biosciences M (IgG1; )
WAS
WASP
Genbank LocusLink 		Alt. gene names: Wiskott Aldrich Syndrome Protein; WASP;
S483 RAIHpSSDEG 685
unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) (WP2401) unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) ECM Biosciences P (Rabbit)
WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific (WP2201) WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific ECM Biosciences P (Rabbit)
S484 AIHSpSDEGE 686
unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) (WP2401) unphosphorylated WASP (Ser-483/Ser-484); N-WASP (Ser-484/Ser-485) ECM Biosciences P (Rabbit)
WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific (WP2201) WASP (Ser-483/Ser-484), N-WASP (Ser-484/Ser-485) phospho-specific ECM Biosciences P (Rabbit)

    References

  1. Brognard J, Clark AS, Ni Y, Dennis PA. 2001. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61:3986-3997 (Abstract) [site(s): S473]
  2. Kitaura J, Asai K, Maeda-Yamamoto M, Kawakami Y, Kikkawa U, Kawakami T. 2000. Akt-dependent cytokine production in mast cells. J Exp Med 192:729-740 (Abstract) [site(s): S473]
  3. Kroner C, Eybrechts K, Akkerman JW. 2000. Dual regulation of platelet protein kinase B. J Biol Chem 275:27790-27798 (Abstract) [site(s): S473]
  4. Lynch DK, Ellis CA, Edwards PA, Hiles ID. 1999. Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene 18:8024-8032 (Abstract) [site(s): S473]
  5. Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Ping P, Pierce W, McLeish KR. 2000. p38 KINASE-DEPENDENT MAPKAPK-2 ACTIVATION FUNCTIONS AS PDK2 FOR AKT IN HUMAN NEUTROPHILS. J Biol Chem : (Abstract) [site(s): S473]
  6. Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL. 2000. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol 20:6945-6957 (Abstract) [site(s): S473]
  7. Shikata Y, Birukov KG, Birukova AA, Verin A, Garcia JG. 2003. Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT. FASEB J 17:2240-9 (Abstract) [site(s): Y397]
  8. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT. 1997. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-570 (Abstract) [site(s): S473]
  9. Toker A, Newton AC. 2000. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem 275:8271-8274 (Abstract) [site(s): S473]