Cancer Control Research
5U01CA069446-06
Buys, Saundra S.
COOPERATIVE BREAST CANCER REGISTRY
AbstractThis application describes a proposal to develop a comprehensive family
registry of individuals who are at high risk for breast cancer. The
registry will consist primarily of individuals ascertained from Utah and
the surrounding region, but will incorporate information and biological
samples from family members regardless of location of residence. The
registry will draw upon the strengths of this population and environment:
the presence of large families with well-defined pedigrees (i.e. large,
informative families); the recently established IRB-approved High Risk
Breast Cancer Clinic (HRBCC); and the existence of well-known programs in
genetics and genetic epidemiology. The establishment of such a registry
will provide the resources for a wide variety of studies on the etiology,
prevention, and treatment of breast cancer. Specifically we propose to:
1. Create a Family Registry which includes:
a. Families of individuals who are identified as genetically predisposed
to breast cancer.
b. Detailed epidemiologic and genetic data on family members.
c. Biological specimens.
2. Provide counseling and follow-up on the individuals enrolled in the
Clinic.
3. To conduct a pilot study examining the radiation sensitivity of breast
epithelial cells from women with BRCA1 mutations, and testing the
hypothesis that BRCA1 carriers demonstrate genomic instability and
accelerated carcinogenesis.
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